NOAEL Studies Cosmetic Ingredient

2-Methylpropanol (Isobutanol) NOAEL Studies

INCI: 2-METHYLPROPANOL

CAS: 78-83-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 160 mg/kg bw/day rat oral 495 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1000 mg/kg bw/day rat oral 93 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1251 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 3700 mg/kg bw/day rat oral 120 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA 26 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =50 mg/kg bw/day Rat oral: gavage 730 days chronic/long term toxicity EFSA FEEDAP - 2012 - OutputID 615 - body weight - systemic - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL =50 mg/kg bw/day Rat oral: gavage 730 days chronic/long term toxicity EFSA FEEDAP - 2012 - OutputID 615 - body weight - systemic - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL =125 mg/kg bw/day Rat oral: gavage 90 days subchronic EFSA FEEDAP - 2012 - OutputID 615 - gross pathology - systemic - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL =125 mg/kg bw/day Rat oral: gavage 90 days subchronic EFSA FEEDAP - 2012 - OutputID 615 - gross pathology - systemic - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL >219 mg/kg bw/day Rat oral: unspecified 90 days subchronic EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL >219 mg/kg bw/day Rat oral: unspecified 90 days subchronic EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL >300 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL >300 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL =340 mg/kg bw/day Rat oral: drinking water 90 days subchronic EFSA FEEDAP - 2012 - OutputID 615 - haematology - hemopoietic - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL =340 mg/kg bw/day Rat oral: drinking water 90 days subchronic EFSA FEEDAP - 2012 - OutputID 615 - haematology - hemopoietic - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL >1000 mg/kg bw/day Rat oral: gavage 119 days chronic/long term toxicity EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL >1000 mg/kg bw/day Rat oral: gavage 119 days chronic/long term toxicity EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL >1450 mg/kg bw/day Rat oral: drinking water 90 days subchronic EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL >1450 mg/kg bw/day Rat oral: drinking water 90 days subchronic EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL >2500 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA NOAEL >2500 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927
EFSA ARfD <=0.3 mg/kg bw/day Consumers - - ARfD EFSA CONTAM - 2009 - OutputID 119 - Consumers - Scientific Opinion on the evaluation of substances as acceptable previous cargoes for edible fats and oils - doi:10.2903/j.efsa.2009.1391
EFSA ARfD <=0.3 mg/kg bw/day Consumers - - ARfD EFSA CONTAM - 2009 - OutputID 119 - Consumers - Scientific Opinion on the evaluation of substances as acceptable previous cargoes for edible fats and oils - doi:10.2903/j.efsa.2009.1391
EFSA NOAEL =50 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15614446:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b5a3e4dec855432624605a7d2f520ce1
EFSA NOAEL =125 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=EFSA:15614447:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af70d90af32df4d393a01847de3965a3
EFSA NOAEL >219 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614450:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fa4740fdf9a6b0cd108117a0b4f250bf
EFSA NOAEL >300 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA_dup_-_15614448_15614449:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d1e62acfe4506deac3d7331d98c15902
EFSA NOAEL =340 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA_dup_-_15614443_15614444:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8f766d972aac7965cf80c0cbb9f8411d
EFSA NOAEL >1000 mg/kg bw/day Rat oral chronic; 17 weeks chronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614445:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b1c6c80555df5299f78662f1475a356
EFSA NOAEL >1450 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA_dup_-_15614443_15614444:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3db50f7ce93fe44421a30f9f29ff13dc
EFSA NOAEL >2500 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA_dup_-_15614448_15614449:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_319f86b4f7355ac56724e644fda8b6d9
Regulatory source 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source NOEL =316 mg/kg/day - oral chronic IRIS chronic oral RfD system PoD row_hash=07b810ed626db2b3; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOEL : 3.16e2 mg/kg-day; system=Nervous; basis=Hypoactivity and ataxia; point_of_departure=NOEL : 3.16e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID0021759; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=169; rfd_last_updated=03/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0169_summary.pdf
Regulatory source RfD =0.3 mg/kg/day - oral chronic IRIS chronic oral RfD system row_hash=e36f5e5c46f207a9; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=3e-1; system=Nervous; basis=Hypoactivity and ataxia; point_of_departure=NOEL : 3.16e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID0021759; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=169; rfd_last_updated=03/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0169_summary.pdf
WHO/JECFA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
WHO/JECFA NOAEL =0.1 mg/m3 - - - Toxicology study document_id=hsg_hsg_hsg009; title=Isobutanol (HSG 9, 1987); path=mirror/documents/hsg/hsg/hsg009.htm; row_hash=f70a42f39c8e34dd; raw_unit=mg/m 3; context=The estimated no-observed-adverse-effect level was 0.1 mg/m 3 .
NTP ICE acute inhalation 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 >6.5 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=188; Record_ID=acute_inhalation_772; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=6.5; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15092/7/3/3/?documentUUID=068b8a5f-7f1d-46bf-8ab8-ac2f0459559b; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759
NTP ICE acute inhalation LC50 >18.18 mg/L - Inhalation Duration=6 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=186; Record_ID=acute_inhalation_775; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=18.18; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15092/7/3/3/?documentUUID=bbd8cf19-015f-4077-91a9-d08e5da1e98f; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759
NTP ICE acute inhalation LC50 19.2 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=185; Record_ID=acute_inhalation_1758; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=19.2; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759
NTP ICE acute inhalation LC50 >21.1 mg/L - Inhalation Duration=7 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=184; Record_ID=acute_inhalation_774; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=21.1; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15092/7/3/3/?documentUUID=e349c2a9-4d0d-47f2-921c-d2e723b0b49b; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759
NTP ICE acute inhalation LC50 24.6 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=187; Record_ID=acute_inhalation_776; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=24.6; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15092/7/3/3/?documentUUID=2bb28f2a-ede7-43d1-b937-1ee0e1f32ed8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759
NTP ICE acute oral 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =2460 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10298; row=544; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-1-propanol; preferred_name=2-Methyl-1-propanol; dtxsid=DTXSID0021759; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021759; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >2830 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_10300; row=543; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-1-propanol; preferred_name=2-Methyl-1-propanol; dtxsid=DTXSID0021759; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021759; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =3100 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10302; row=542; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-1-propanol; preferred_name=2-Methyl-1-propanol; dtxsid=DTXSID0021759; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021759; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =3350 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_10304; row=541; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-1-propanol; preferred_name=2-Methyl-1-propanol; dtxsid=DTXSID0021759; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021759; source_file=acute_oral.xlsx
NTP ICE eye irritation 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE eye irritation Draize rabbit irritation score 60.3 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=108; Record_ID=eye_irritation_156; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=60.3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759
NTP ICE eye irritation EPA Classification 1 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=104; Record_ID=eye_irritation_156; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759
NTP ICE eye irritation GHS Classification 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=109; Record_ID=eye_irritation_156; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759
NTP ICE eye irritation Intensity 0.24 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=107; Record_ID=eye_irritation_1294; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Vitrigel; Endpoint=Intensity; Response=0.24; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759
NTP ICE eye irritation Lag time 10 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=103; Record_ID=eye_irritation_1294; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Vitrigel; Endpoint=Lag time; Response=10; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759
NTP ICE eye irritation Plateau level 44.1 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=106; Record_ID=eye_irritation_1294; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Vitrigel; Endpoint=Plateau level; Response=44.1; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759
ToxValDB DOE Protective Action Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB DOE Protective Action Criteria LEL =51537.7 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15516340:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a3fcec976e0252fc210e095b66d3c3d6
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =310 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633485:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a2204c0ac12e8da3df3bbe9a9f05177
ToxValDB HESS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOAEL =316 mg/kg bw/day Rat oral subchronic; 90 days subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0de8e4b0a676289de5e1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Deaths|Clinical Observation: Hypoactivity Ataxia Salivation Labored respiration Rales Prostration Hypothermia Emaciation|Body Weight Changes: decrease, Body weight gain decrease|Food Consumption: decrease; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival; STUDY_GROUP=HESS:15638252:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_48af5cd881c43fd9dcf6a800ed45799a
ToxValDB HESS NOAEL =2432 mg/kg bw/day Rat oral - subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0de9e4b0a676289de5e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; STUDY_GROUP=HESS:15638251:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_03a4263b358488db98da320d03da6fce
ToxValDB IRIS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB IRIS LOAEL =1000 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=U.S. EPA. 1986. Rat oral subchronic toxicity study with isobutyl alcohol. Office of Solid Waste, Washington, DC.; TITLE=Rat oral subchronic toxicity study with isobutyl alcohol; AUTHOR=U.S. EPA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a50a8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=169; TOXICOLOGICAL_EFFECT=hypoactivity and ataxia; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=IRIS_dup_IRIS Summary_15645001_15645002:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bd788ebd1e25d76211963fd11d8c1dfb
ToxValDB IRIS RfD =0.3 mg/kg bw/day Human oral - Toxicity Value LONG_REF=U.S. EPA, 1986; AUTHOR=U.S. EPA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a50a8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=169; TOXICOLOGICAL_EFFECT=Hypoactivity and ataxia in male/female rats; STUDY_GROUP=IRIS:15644989:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e23939ba78deb796f29c7c41f996ab3d
ToxValDB RSL 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB RSL RfC =0.4 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15656889:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e0d27b84bd43af3a9c592c820352021
ToxValDB RSL RfC =1 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663515:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87a488698f54a2d08ba1b665c1162771
ToxValDB RSL RfD =3 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663514:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6465a3ba3a98a7b0baa7ecafa8d859a2
openFDA substances 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 56F9Z98TEM UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"56F9Z98TEM"}
openFDA substances FDA UNII substance identifier 56F9Z98TEM UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"56F9Z98TEM"}
openFDA substances FDA UNII substance identifier 56F9Z98TEM UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"56F9Z98TEM"}