Good Cosmetic Ingredient NOAEL Data GHS Classified

2-Methylpropanol (Isobutanol)

INCI: 2-METHYLPROPANOL

CAS Number
78-83-1
Function
Fragrance
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically restricted by FDA for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

5 study endpoints found for 2-Methylpropanol (Isobutanol). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 3700 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 160 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 1251 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 1251 mg/kg bw/day oral rat Subchronic COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is severely irritating to the eyes. The substance is irritating to the skin. Exposure far above the OEL could cause lowering of consciousness. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

Eye and mucous membrane irritant at high concentrations; CNS depressant only at very high occupational exposures not typical in cosmetic use. Flammable—storage considerations apply.

⚠️
Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is 2-Methylpropanol (Isobutanol) safe in cosmetics?

Eye and mucous membrane irritant at high concentrations; CNS depressant only at very high occupational exposures not typical in cosmetic use. Flammable—storage considerations apply. The EU classifies 2-Methylpropanol (Isobutanol) as "permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.

Is 2-Methylpropanol (Isobutanol) allowed in the EU?

2-Methylpropanol (Isobutanol) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Methylpropanol (Isobutanol) do in cosmetics?

2-Methylpropanol (Isobutanol) functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 78-83-1.

What is the Margin of Safety for 2-Methylpropanol (Isobutanol)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2-Methylpropanol (Isobutanol)?

The NOAEL (No Observed Adverse Effect Level) for 2-Methylpropanol (Isobutanol) is 3700 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check 2-Methylpropanol (Isobutanol) compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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