NOAEL Studies
Cosmetic Ingredient
2-METHYLPROPANOL NOAEL Studies
CAS: 78-83-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 3700 | mg/kg bw/day | rat | oral | 120 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 160 | mg/kg bw/day | rat | oral | 495 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1251 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 93 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | >1000 | mg/kg bw/day | Rat | oral: gavage | 119 days | chronic/long term toxicity | EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =50 | mg/kg bw/day | Rat | oral: gavage | 730 days | chronic/long term toxicity | EFSA FEEDAP - 2012 - OutputID 615 - body weight - systemic - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =340 | mg/kg bw/day | Rat | oral: drinking water | 90 days | subchronic | EFSA FEEDAP - 2012 - OutputID 615 - haematology - hemopoietic - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | >1450 | mg/kg bw/day | Rat | oral: drinking water | 90 days | subchronic | EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | >300 | mg/kg bw/day | Rat | oral: feed | 90 days | subchronic | EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | >2500 | mg/kg bw/day | Rat | oral: feed | 90 days | subchronic | EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =125 | mg/kg bw/day | Rat | oral: gavage | 90 days | subchronic | EFSA FEEDAP - 2012 - OutputID 615 - gross pathology - systemic - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | >219 | mg/kg bw/day | Rat | oral: unspecified | 90 days | subchronic | EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | >1000 | mg/kg bw/day | Rat | oral: gavage | 119 days | chronic/long term toxicity | EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =50 | mg/kg bw/day | Rat | oral: gavage | 730 days | chronic/long term toxicity | EFSA FEEDAP - 2012 - OutputID 615 - body weight - systemic - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =340 | mg/kg bw/day | Rat | oral: drinking water | 90 days | subchronic | EFSA FEEDAP - 2012 - OutputID 615 - haematology - hemopoietic - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | >1450 | mg/kg bw/day | Rat | oral: drinking water | 90 days | subchronic | EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | >300 | mg/kg bw/day | Rat | oral: feed | 90 days | subchronic | EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | >2500 | mg/kg bw/day | Rat | oral: feed | 90 days | subchronic | EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =125 | mg/kg bw/day | Rat | oral: gavage | 90 days | subchronic | EFSA FEEDAP - 2012 - OutputID 615 - gross pathology - systemic - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | >219 | mg/kg bw/day | Rat | oral: unspecified | 90 days | subchronic | EFSA FEEDAP - 2012 - OutputID 615 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2927 |
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ARfD | <=0.3 | mg/kg bw/day | Consumers | - | - | ARfD | EFSA CONTAM - 2009 - OutputID 119 - Consumers - Scientific Opinion on the evaluation of substances as acceptable previous cargoes for edible fats and oils - doi:10.2903/j.efsa.2009.1391 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ARfD | <=0.3 | mg/kg bw/day | Consumers | - | - | ARfD | EFSA CONTAM - 2009 - OutputID 119 - Consumers - Scientific Opinion on the evaluation of substances as acceptable previous cargoes for edible fats and oils - doi:10.2903/j.efsa.2009.1391 |
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfd_systems.csv | NOEL | =316 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=07b810ed626db2b3; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOEL : 3.16e2 mg/kg-day; system=Nervous; basis=Hypoactivity and ataxia; point_of_departure=NOEL : 3.16e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID0021759; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=169; rfd_last_updated=03/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0169_summary.pdf |
| EPA_IRIS_iris_rfd_systems.csv | RfD | =0.3 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=e36f5e5c46f207a9; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=3e-1; system=Nervous; basis=Hypoactivity and ataxia; point_of_departure=NOEL : 3.16e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID0021759; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=169; rfd_last_updated=03/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0169_summary.pdf |
INCHEM_WHO_hsg_hsg_hsg009 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_hsg_hsg_hsg009 | NOAEL | =0.1 | mg/m3 | - | - | - | Toxicology study | document_id=hsg_hsg_hsg009; title=Isobutanol (HSG 9, 1987); path=mirror/documents/hsg/hsg/hsg009.htm; row_hash=f70a42f39c8e34dd; raw_unit=mg/m 3; context=The estimated no-observed-adverse-effect level was 0.1 mg/m 3 . |
NTP_ICE_acute_inhalation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | >21.1 | mg/L | - | Inhalation | Duration=7 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=184; Record_ID=acute_inhalation_774; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=21.1; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15092/7/3/3/?documentUUID=e349c2a9-4d0d-47f2-921c-d2e723b0b49b; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759 |
| NTP_ICE_acute_inhalation | LC50 | 19.2 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=185; Record_ID=acute_inhalation_1758; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=19.2; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759 |
| NTP_ICE_acute_inhalation | LC50 | >18.18 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=186; Record_ID=acute_inhalation_775; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=18.18; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15092/7/3/3/?documentUUID=bbd8cf19-015f-4077-91a9-d08e5da1e98f; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759 |
| NTP_ICE_acute_inhalation | LC50 | 24.6 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=187; Record_ID=acute_inhalation_776; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=24.6; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15092/7/3/3/?documentUUID=2bb28f2a-ede7-43d1-b937-1ee0e1f32ed8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759 |
| NTP_ICE_acute_inhalation | LC50 | >6.5 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=188; Record_ID=acute_inhalation_772; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=6.5; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15092/7/3/3/?documentUUID=068b8a5f-7f1d-46bf-8ab8-ac2f0459559b; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759 |
NTP_ICE_acute_oral 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =3350 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_10304; row=541; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-1-propanol; preferred_name=2-Methyl-1-propanol; dtxsid=DTXSID0021759; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021759; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =3100 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10302; row=542; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-1-propanol; preferred_name=2-Methyl-1-propanol; dtxsid=DTXSID0021759; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021759; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2830 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10300; row=543; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-1-propanol; preferred_name=2-Methyl-1-propanol; dtxsid=DTXSID0021759; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021759; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =2460 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10298; row=544; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-1-propanol; preferred_name=2-Methyl-1-propanol; dtxsid=DTXSID0021759; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021759; source_file=acute_oral.xlsx |
NTP_ICE_eye_irritation 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 60.3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=108; Record_ID=eye_irritation_156; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=60.3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759 |
| NTP_ICE_eye_irritation | EPA Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=104; Record_ID=eye_irritation_156; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759 |
| NTP_ICE_eye_irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=109; Record_ID=eye_irritation_156; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759 |
| NTP_ICE_eye_irritation | Intensity | 0.24 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=107; Record_ID=eye_irritation_1294; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Vitrigel; Endpoint=Intensity; Response=0.24; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759 |
| NTP_ICE_eye_irritation | Lag time | 10 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=103; Record_ID=eye_irritation_1294; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Vitrigel; Endpoint=Lag time; Response=10; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759 |
| NTP_ICE_eye_irritation | Plateau level | 44.1 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=106; Record_ID=eye_irritation_1294; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021759; Assay=Vitrigel; Endpoint=Plateau level; Response=44.1; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021759; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021759 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =51537.7 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15516340:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a3fcec976e0252fc210e095b66d3c3d6 |
ToxValDB_EFSA 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | >1450 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA_dup_-_15614443_15614444:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3db50f7ce93fe44421a30f9f29ff13dc |
| ToxValDB_EFSA | NOAEL | =340 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA_dup_-_15614443_15614444:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8f766d972aac7965cf80c0cbb9f8411d |
| ToxValDB_EFSA | NOAEL | >1000 | mg/kg bw/day | Rat | oral | chronic; 17 weeks | chronic | LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614445:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b1c6c80555df5299f78662f1475a356 |
| ToxValDB_EFSA | NOAEL | =50 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15614446:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b5a3e4dec855432624605a7d2f520ce1 |
| ToxValDB_EFSA | NOAEL | =125 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=EFSA:15614447:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af70d90af32df4d393a01847de3965a3 |
| ToxValDB_EFSA | NOAEL | >2500 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA_dup_-_15614448_15614449:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_319f86b4f7355ac56724e644fda8b6d9 |
| ToxValDB_EFSA | NOAEL | >300 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA_dup_-_15614448_15614449:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d1e62acfe4506deac3d7331d98c15902 |
| ToxValDB_EFSA | NOAEL | >219 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614450:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fa4740fdf9a6b0cd108117a0b4f250bf |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =310 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633485:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a2204c0ac12e8da3df3bbe9a9f05177 |
ToxValDB_HESS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOAEL | =2432 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0de9e4b0a676289de5e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; STUDY_GROUP=HESS:15638251:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_03a4263b358488db98da320d03da6fce |
| ToxValDB_HESS | NOAEL | =316 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0de8e4b0a676289de5e1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Deaths|Clinical Observation: Hypoactivity Ataxia Salivation Labored respiration Rales Prostration Hypothermia Emaciation|Body Weight Changes: decrease, Body weight gain decrease|Food Consumption: decrease; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival; STUDY_GROUP=HESS:15638252:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_48af5cd881c43fd9dcf6a800ed45799a |
ToxValDB_IRIS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_IRIS | LOAEL | =1000 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=U.S. EPA. 1986. Rat oral subchronic toxicity study with isobutyl alcohol. Office of Solid Waste, Washington, DC.; TITLE=Rat oral subchronic toxicity study with isobutyl alcohol; AUTHOR=U.S. EPA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a50a8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=169; TOXICOLOGICAL_EFFECT=hypoactivity and ataxia; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=IRIS_dup_IRIS Summary_15645001_15645002:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bd788ebd1e25d76211963fd11d8c1dfb |
| ToxValDB_IRIS | RfD | =0.3 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=U.S. EPA, 1986; AUTHOR=U.S. EPA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a50a8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=169; TOXICOLOGICAL_EFFECT=Hypoactivity and ataxia in male/female rats; STUDY_GROUP=IRIS:15644989:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e23939ba78deb796f29c7c41f996ab3d |
ToxValDB_RSL 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_RSL | RfC | =0.4 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15656889:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e0d27b84bd43af3a9c592c820352021 |
| ToxValDB_RSL | RfC | =1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663515:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87a488698f54a2d08ba1b665c1162771 |
| ToxValDB_RSL | RfD | =3 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663514:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6465a3ba3a98a7b0baa7ecafa8d859a2 |
openFDA substances 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 56F9Z98TEM | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"56F9Z98TEM"} |
| openFDA substances | FDA UNII substance identifier | 56F9Z98TEM | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"56F9Z98TEM"} |
| openFDA substances | FDA UNII substance identifier | 56F9Z98TEM | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"56F9Z98TEM"} |