Good Cosmetic Ingredient NOAEL Data GHS Classified

2-METHYLPROPANOL

CAS Number
78-83-1
Function
Perfuming
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status Permitted
🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

5 study endpoints found for 2-METHYLPROPANOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 3700 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 160 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 1251 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 1251 mg/kg bw/day oral rat Subchronic COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is severely irritating to the eyes. The substance is irritating to the skin. Exposure far above the OEL could cause lowering of consciousness. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

2-METHYLPROPANOL is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions.

⚠️
Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted fragrance needs-enrichment ifra_fragrance fda_food_additive

Frequently Asked Questions

Is 2-METHYLPROPANOL safe in cosmetics?

2-METHYLPROPANOL is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions. The EU classifies 2-METHYLPROPANOL as "Permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.

Is 2-METHYLPROPANOL allowed in the EU?

2-METHYLPROPANOL EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-METHYLPROPANOL do in cosmetics?

2-METHYLPROPANOL functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 78-83-1.

What is the NOAEL for 2-METHYLPROPANOL?

The NOAEL (No Observed Adverse Effect Level) for 2-METHYLPROPANOL is 3700 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check 2-METHYLPROPANOL compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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