Is 2-METHYLPROPANOL safe in cosmetics?
2-METHYLPROPANOL has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.
2-METHYLPROPANOL
Also known as: Isobutyl alcohol, 4-01-00-01588, BRN 1730878, EINECS 201-148-0, FEMA No. 2179 (+14 more)
2-METHYLPROPANOL (CAS 78-83-1) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 78-83-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-METHYLPROPANOL is classified GHS Danger (H226, H315, H318, H335, H336, H303, H305, H313) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
2-methylpropan-1-ol
InChIKey
ZXEKIIBDNHEJCQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for 2-METHYLPROPANOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 160 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is severely irritating to the eyes. The substance is irritating to the skin. Exposure far above the OEL could cause lowering of consciousness. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 2-METHYLPROPANOL across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LEL | =51537.7 mg/m3 | Human | inhalation | - | DOE Protective Action Criteria |
| NOAEL | >1450 mg/kg-day | Rat | oral | subchronic | EFSA |
| NOAEL | =340 mg/kg-day | Rat | oral | subchronic | EFSA |
| NOAEL | >1000 mg/kg-day | Rat | oral | chronic | EFSA |
| NOAEL | =50 mg/kg-day | Rat | oral | chronic | EFSA |
| NOAEL | =125 mg/kg-day | Rat | oral | subchronic | EFSA |
| NOAEL | >2500 mg/kg-day | Rat | oral | subchronic | EFSA |
| NOAEL | >300 mg/kg-day | Rat | oral | subchronic | EFSA |
| NOAEL | >219 mg/kg-day | Rat | oral | subchronic | EFSA |
| NOAEL | =300 mg/kg-day | Rat | oral | subchronic | MN MDH HHBW |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / IrritantCorrosive
Hazard Class and Category
Flam. Liq. 3; STOT SE 3; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
Hazard Statements
- H226 Flammable liquid and vapour
- H335 May cause respiratory irritation
- H336 May cause drowsiness or dizziness
- H315 Causes skin irritation
- H318 Causes serious eye damage
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0113
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Vapor: Irritating to eyes, nose and throat. | Potential symptoms of overexposure are irritation of eyes and throat: headache, drowsiness; skin cracking. | ... Stated to be a skin irritant ... | Isobutanol is not very irritating to skin, but it is severly irritating to the eye.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (3)
JECFA Number
251
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOPROPYL CARBINOL | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/37 | FAS 40-JECFA 49/189
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOBUTANOL | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/37 | FAS 40-JECFA 49/189
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Adhesion/cohesion promoter
Flavouring and nutrient
Fragrance
No specific technical function
Plasticizer
Solvent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 2-METHYLPROPANOL.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2-METHYLPROPANOL by CAS number or substance name.
Studies
1
Lowest NOAEL
160 mg/kg bw/day
Highest NOAEL
160 mg/kg bw/day
COSMOS_DB
Known Synonyms
Isobutyl alcohol
4-01-00-01588
BRN 1730878
EINECS 201-148-0
FEMA No. 2179
FEMA Number 2179
Fermentation butyl alcohol
RCRA waste number U140
UNII-56F9Z98TEM
1-hydroxymethylpropane
2-Methyl-1-propanyl alcohol
2-MethylpropanoI
2-Methylpropanol-1
Alcool isobutylique
IBA
Isobutylalkohol
Isopropyl carbitol
Methyl-2 propanol-1
i-Butanol
Chemical Function
Fragrance
No specific technical function
Solvent
Flavouring and nutrient
Regulatory Lists
air; detected; emissions; Europe; Furniture and Furnishings
air; detected; emissions; Europe; Other indirect contact consumer goods
air; Construction and building materials; detected; emissions; Europe
air; detected; emissions; Europe; Toys and children's products
air; Cons electronics mech appliances and machinery; detected; emissions; Europe
Cons electronics mech appliances and machinery; detected; emissions; Europe
air; Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; Europe
air; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Toys and children's products
Cleaning products and household care - shoes; Europe
Cleaning products and household care - shoes; Europe
active_ingredient; Europe; Pesticides
Europe
air; detected; emissions; Europe; Home maintenance - caulk/sealant
inert_ingredient; non_food_use; Pesticides
Australia; Food and drug - smoking-related products
IFRA Transparency
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ISOBUTANOL
ChEMBL ID
CHEMBL269630
Frequently Asked Questions
Is 2-METHYLPROPANOL allowed in the EU?
2-METHYLPROPANOL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-METHYLPROPANOL do in cosmetics?
2-METHYLPROPANOL functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 78-83-1.
What is the NOAEL for 2-METHYLPROPANOL?
The NOAEL (No Observed Adverse Effect Level) for 2-METHYLPROPANOL is 160 mg/kg bw/day based on a Chronic study via oral route in rat. Source: COSMOS_DB.
Is 2-METHYLPROPANOL used outside cosmetics?
2-METHYLPROPANOL also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-METHYLPROPANOL have different safety status in cosmetics vs industrial chemicals?
2-METHYLPROPANOL is classified GHS Danger (H226, H315, H318, H335, H336, H303, H305, H313) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check 2-METHYLPROPANOL compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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