NOAEL Studies Cosmetic Ingredient

2-Methylresorcinol NOAEL Studies

INCI: 2-METHYLRESORCINOL

CAS: 608-25-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 100 mg/kg bw/day rat oral 90 day Subchronic SCCP; van Otterdijk, F.M. (2005). Repeated dose 90-day oral toxicity study with A 044 bydaily gavage in the rat followed by a 28-day recovery period. NOTOX, internal study code: 426757, Report No. 0500261
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_8326; row=813; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-1,3-benzenediol; preferred_name=2-Methyl-1,3-benzenediol; dtxsid=DTXSID0025571; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025571; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0025571; source_file=acute_oral.xlsx
SCCS Opinion 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.024 mg/kg human dermal Sub-chronic repeated dose toxicity p.20
SCCS Opinion NOAEL =0.024 mg/kg bw human dermal Sub-chronic repeated dose toxicity p.20
SCCS Opinion NOAEL =0.14 mg/kg bw human dermal Sub-chronic repeated dose toxicity p.20
SCCS Opinion NOAEL =100 mg/kg bw - - Chronic genotoxicity p.14
SCCS Opinion NOAEL =100 mg/kg human dermal Sub-chronic repeated dose toxicity p.20
SCCS Opinion NOAEL =100 mg/kg bw - - Chronic NOAEL study p.14
SCCS Opinion NOAEL =400 mg/kg bw/day - - developmental reproductive toxicity p.19
SCCS Opinion NOAEL =900 mg/kg bw rat oral - developmental toxicity p.18
ECHA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =100 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7ee4b0a7c65d1c9831; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5570/7/6/2?documentUUID=2108d37c-25f6-41fe-8b0c-e011db1dd3b5; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=ECHA IUCLID:15845829:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d298ac954f591a57852dda6f36ef9d9a
ECHA NOAEL =400 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8d82; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5570/7/9/2?documentUUID=2108d37c-25f6-41fe-8b0c-e011db1dd3b5; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=ECHA IUCLID:15857170:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e597db18e42dd3b361ab83a4d9a03470
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =4.93 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631264:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_700cfe813d5f6e0f5d7d7024dbafd021
Regulatory source 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 100 mg/kg bw - - Chronic - p.14
Regulatory source dermal absorption 400 mg/kg bw/day mouse dermal 90-day dermal absorption p.21
Regulatory source developmental toxicity 900 mg/kg bw rat oral - developmental toxicity p.18
Regulatory source genotoxicity 100 mg/kg bw - - Chronic genotoxicity p.14
Regulatory source irritation 100 mg/kg bw rabbit - 90-day irritation p.20
Regulatory source irritation 100 mg/kg bw mouse - 90-day irritation p.20
Regulatory source irritation 400 mg/kg bw/day mouse - 90-day irritation p.20
Regulatory source repeated dose toxicity =0.024 mg/kg human dermal Sub-chronic repeated dose toxicity p.20
Regulatory source repeated dose toxicity =0.024 mg/kg bw human dermal Sub-chronic repeated dose toxicity p.20
Regulatory source repeated dose toxicity =0.14 mg/kg bw human dermal Sub-chronic repeated dose toxicity p.20
Regulatory source repeated dose toxicity =100 mg/kg human dermal Sub-chronic repeated dose toxicity p.20
Regulatory source repeated dose toxicity =100 mg/kg bw human dermal Sub-chronic repeated dose toxicity p.20
Regulatory source reproductive toxicity 400 mg/kg bw/day - - developmental reproductive toxicity p.19
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 32W7044A3T UNII - - - chemical -