Moderate Cosmetic Ingredient NOAEL Data SCCS/CIR Reviewed

2-Methylresorcinol

INCI: 2-METHYLRESORCINOL

CAS Number

608-25-3

Function

Hair dyeing (oxidative and non-oxidative hair colorant coupler)

Safety Rating

MODERATE

Regulatory Status

🇪🇺 EU Status restricted

EU Max Conc. 1.8%

🇺🇸 US Status permitted

US Notes Permitted for hair dye use under coal tar hair dye provisions (FD\&C Act §601(a)); requires caution statement and patch test directions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

moderate

Sensitization

moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for 2-Methylresorcinol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
LOAEL	100 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	100 mg/kg bw/day	oral	rat	oral	REACH

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir Number 3, 1986

Verdict: unknown

Expert Verdict

Not for eyelash/eyebrow use; mandatory labeling requirement; potential endocrine activity flagged for parent compound resorcinol; professional vs. consumer use distinction important

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Concern Level: Moderate

Regulatory Flags

colorant endocrine_disruptor eu_cosing_listed

Frequently Asked Questions

Is 2-Methylresorcinol safe in cosmetics?

Not for eyelash/eyebrow use; mandatory labeling requirement; potential endocrine activity flagged for parent compound resorcinol; professional vs. consumer use distinction important The EU classifies 2-Methylresorcinol as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is 2-Methylresorcinol allowed in the EU?

2-Methylresorcinol EU regulatory status: restricted. Maximum allowed concentration: 1.8%. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Methylresorcinol do in cosmetics?

2-Methylresorcinol functions as: Hair dyeing (oxidative and non-oxidative hair colorant coupler). It is classified as a cosmetic ingredient in our database. CAS number: 608-25-3.

What is the Margin of Safety for 2-Methylresorcinol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2-Methylresorcinol?

The NOAEL (No Observed Adverse Effect Level) for 2-Methylresorcinol is 100 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check 2-Methylresorcinol compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

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MoS Calculator

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Heavy Metal Limits

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