Also known as: 4-06-00-05877, BRN 2042177, EINECS 210-155-8, UNII-32W7044A3T
INCI: 2-METHYLRESORCINOL
2-Methylresorcinol (CAS 608-25-3) is a cosmetic cosmetic ingredient functioning as Hair dyeing (oxidative and non-oxidative hair colorant coupler). Reported NOAEL =0.024 mg/kg in human (SCCS Opinion); EU Regulation 1223/2009 status: restricted, max 1.8%; 1 safety opinion reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
2-Methylresorcinol is classified GHS Danger (H301, H315, H317, H318, H319, H335, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 1.8%.
Source: Cosmetics: ingredients.eu status/eu max; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Methylresorcinol.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for 2-Methylresorcinol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.024 mg/kg | dermal | human | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.024 mg/kg bw | dermal | human | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.024 mg/kg | dermal | human | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.024 mg/kg | dermal | human | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.024 mg/kg bw | dermal | human | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.024 mg/kg bw | dermal | human | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.024 mg/kg | dermal | human | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.024 mg/kg bw | dermal | human | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.14 mg/kg bw | dermal | human | repeated dose toxicity | SCCS Opinion |
| NOAEL | =0.14 mg/kg bw | dermal | human | repeated dose toxicity | SCCS Opinion |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
A margin-of-safety result previously shown for 2-Methylresorcinol has been withdrawn pending re-verification. We don't display safety verdicts we can't fully substantiate from the primary SCCS source — so this entry is being re-checked rather than shown unverified.
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: LLNA: CosmEur database; DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | restricted | - | Hair dye oxidative products only |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 1.8% | - | - | SCCP/0071 |
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Preliminary editorial summary for 2-Methylresorcinol — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to 2-Methylresorcinol by CAS number or substance name.
Units vary across source rows: mg/kg, mg/kg bw, mg/kg bw/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 1.8% | - | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
2-Methylresorcinol has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
2-Methylresorcinol EU regulatory status: restricted. Maximum allowed concentration: 1.8%. This is based on EU Regulation 1223/2009 and its amendments.
2-Methylresorcinol functions as: Hair dyeing (oxidative and non-oxidative hair colorant coupler). It is classified as a cosmetic ingredient in our database. CAS number: 608-25-3.
The NOAEL (No Observed Adverse Effect Level) for 2-Methylresorcinol is =0.024 mg/kg based on a repeated dose toxicity study via dermal route in human. A total of 10 study endpoints are available. Source: SCCS Opinion.
2-Methylresorcinol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
2-Methylresorcinol is classified GHS Danger (H301, H315, H317, H318, H319, H335, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 1.8%.
Check 2-Methylresorcinol compliance across multiple jurisdictions:
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