NOAEL Studies Cosmetic Ingredient

2-NAPHTHOL NOAEL Studies

CAS: 135-19-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 >0.77 mg/L - Inhalation Duration=1 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2941; Record_ID=acute_inhalation_3073; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5027061; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.77; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027061
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1960 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2386; row=8942; data_type=In Vivo; mixture=Chemical; chemical_name=2-Naphthalenol; preferred_name=2-Naphthalenol; dtxsid=DTXSID5027061; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027061; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 119 uL/min/10^6 cells Rat - - Measured; httk, Rat Hepatic Intrinsic Clearance sheet=Data; excel_row=2101; Record_ID=adme_parameters_1370; Data_Type=Measured; DTXSID=DTXSID5027061; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=119.0; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027061
NTP_ICE_adme_parameters Fu 6.98e-7 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2099; Record_ID=adme_parameters_1370; Data_Type=Measured; DTXSID=DTXSID5027061; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=6.98e-07; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027061
NTP_ICE_adme_parameters Fu 0.0513 fraction Rat - - Measured; httk, Rat Plasma Fraction Unbound sheet=Data; excel_row=2100; Record_ID=adme_parameters_1370; Data_Type=Measured; DTXSID=DTXSID5027061; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.0513; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027061
NTP_ICE_endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 46.014553587878 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=2638; RecordID=ERPathway2016_247; DatasetName=ERPathway2016; DTXSID=DTXSID5027061; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=46.014553587878; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027061
NTP_ICE_endocrine ACC 22.4415221419953 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=2639; RecordID=ERPathway2016_247; DatasetName=ERPathway2016; DTXSID=DTXSID5027061; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=22.4415221419953; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027061
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=2634; RecordID=ARPathway2016_800; DatasetName=ARPathway2016; DTXSID=DTXSID5027061; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027061
NTP_ICE_endocrine Model Score 0.0874 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=2640; RecordID=ERPathway2016_247; DatasetName=ERPathway2016; DTXSID=DTXSID5027061; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0874; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5027061
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1.76 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633717:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_00b08b1af69aede04ec83bc7cac5e51e
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier P2Z71CIK5H UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H8O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P2Z71CIK5H"}
openFDA substances FDA UNII substance identifier P2Z71CIK5H UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H8O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P2Z71CIK5H"}
openFDA substances FDA UNII substance identifier P2Z71CIK5H UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H8O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P2Z71CIK5H"}
openFDA substances FDA UNII substance identifier P2Z71CIK5H UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H8O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P2Z71CIK5H"}