Moderate Cosmetic Ingredient NOAEL Data GHS Classified

2-NAPHTHOL

CAS Number
135-19-3
Function
Hair Dyeing, Perfuming
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status Restricted
EU Max Conc. II/241
🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

4 study endpoints found for 2-NAPHTHOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 150 mg/kg bw/day oral rat oral REACH
LOAEL 10080 other oral rat oral REACH
LOAEL 107 other oral rat oral REACH
LOAEL 298 other oral rabbit oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is severely irritating to the eyes.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the kidneys, blood and eyes. This may result in kidney impairment, anaemia and lens opacities.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Expert Verdict

2-NAPHTHOL is listed in the EU CosIng database with functions: Hair Dyeing, Perfuming It is restricted under EU Cosmetics Regulation. Restriction: II/241.

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Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted fragrance needs-enrichment endocrine_disruptor eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 2-NAPHTHOL safe in cosmetics?

2-NAPHTHOL is listed in the EU CosIng database with functions: Hair Dyeing, Perfuming It is restricted under EU Cosmetics Regulation. Restriction: II/241. The EU classifies 2-NAPHTHOL as "Restricted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.

Is 2-NAPHTHOL allowed in the EU?

2-NAPHTHOL EU regulatory status: Restricted. Maximum allowed concentration: II/241. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-NAPHTHOL do in cosmetics?

2-NAPHTHOL functions as: Hair Dyeing, Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 135-19-3.

What is the NOAEL for 2-NAPHTHOL?

The NOAEL (No Observed Adverse Effect Level) for 2-NAPHTHOL is 150 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.

Compliance Tools

Check 2-NAPHTHOL compliance across multiple jurisdictions:

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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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