NOAEL Studies Cosmetic Ingredient

2-Nitro-5-Glyceryl Methylaniline NOAEL Studies

INCI: 2-NITRO-5-GLYCERYL METHYLANILINE

CAS: 80062-31-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 50 mg/kg bw/day rat oral 90 day Subchronic SCCS; C. Fabreguettes. Imexine FT: 13-Week Toxicity Study by Oral Route in Rats. CITStudy No. 11389 TCR (CIES1 94022), 1995
SCCNFP Opinion 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =100 mg/kg bw/day - dermal - repeated dose toxicity Ref. : 5 2, p.6
SCCNFP Opinion NOAEL =100 mg/kg bw rabbit oral 30 d repeated dose toxicity p.16
SCCS Opinion 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.011 mg/kg bw/d rat oral 13 weeks dermal absorption p.30
SCCS Opinion NOAEL =0.04 mg/kg bw/d rat oral 13 weeks dermal absorption p.30
SCCS Opinion NOAEL =50 mg/kg bw - - 28 days genotoxicity p.16
SCCS Opinion NOAEL =50 mg/kg/day rat oral 13-week irritation p.28
SCCS Opinion NOAEL =100 mg/kg bw/day - - - NOAEL study p.14
SCCS Opinion NOAEL =200 mg/kg bw/d - - 28 days genotoxicity p.17
SCCS Opinion NOAEL =300 mg/kg/day - - - NOAEL study p.26
SCCS Opinion NOAEL =300 mg/kg bw/day - - - NOAEL study p.28
SCCS Opinion NOAEL =800 mg/kg/day - - 28 days genotoxicity p.16
SCCS Opinion NOAEL =800 mg/kg bw/day - - - NOAEL study Ref.: 5 Comment, p.16
Regulatory source 18 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source repeated dose toxicity 100 mg/kg bw/day - dermal - repeated dose toxicity p.6
Regulatory source repeated dose toxicity 100 mg/kg bw rabbit oral 30 d repeated dose toxicity p.16
Regulatory source - 100 mg/kg bw/day - - - - p.14
Regulatory source - 100 mg/kg bw - - - - p.14
Regulatory source - 300 mg/kg/day - - - - p.26
Regulatory source - 300 mg/kg bw/day - - - - p.28
Regulatory source - 800 mg/kg bw/day - - - - p.16
Regulatory source dermal absorption =0.011 mg/kg bw/d rat oral 13 weeks dermal absorption p.30
Regulatory source dermal absorption =0.04 mg/kg bw/d rat oral 13 weeks dermal absorption p.30
Regulatory source dermal absorption =200 mg/kg bw/d rat oral 13 weeks dermal absorption p.30
Regulatory source dermal absorption 300 mg/kg/day rat oral 13-week dermal absorption p.28
Regulatory source dermal absorption 300 mg/kg bw/day rabbit dermal 90 days dermal absorption p.31
Regulatory source genotoxicity 50 mg/kg bw - - 28 days genotoxicity p.16
Regulatory source genotoxicity 200 mg/kg bw/d - - 28 days genotoxicity p.17
Regulatory source genotoxicity 800 mg/kg/day - - 28 days genotoxicity p.16
Regulatory source irritation 50 mg/kg/day rat oral 13-week irritation p.28
Regulatory source irritation 50 mg/kg bw rabbit - 90 days irritation p.31
Regulatory source irritation 200 mg/kg bw/d rabbit - 90 days irritation p.31
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier Y6YE3133F5 UNII - - - chemical -