Is 2-Nitro-5-Glyceryl Methylaniline safe in cosmetics?
2-Nitro-5-Glyceryl Methylaniline has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
2-Nitro-5-Glyceryl Methylaniline
INCI: 2-NITRO-5-GLYCERYL METHYLANILINE
2-Nitro-5-Glyceryl Methylaniline (CAS 80062-31-3) is a cosmetic cosmetic ingredient functioning as Non-oxidative (semi-permanent) hair dye. Reported NOAEL =100 mg/kg bw/day (SCCNFP_vision_codex); EU Regulation 1223/2009 status: prohibited, max 1.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 80062-31-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Nitro-5-Glyceryl Methylaniline is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Non-oxidative (semi-permanent) hair dye
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-[3-(methylamino)-4-nitrophenoxy]propane-1,2-diol
InChIKey
CDRHDQOGKXFJSA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
1.0%
US US Status
permitted
US Notes
Permitted under the FD&C Act coal tar hair dye exemption; not separately restricted by FDA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Nitro-5-Glyceryl Methylaniline.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 2-Nitro-5-Glyceryl Methylaniline. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw | oral | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw | oral | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw | oral | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw | oral | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =0.011 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.011 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products. Max: (b) 1.0 %.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 1.0 %
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (5 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.2% | - | - | SCCP/0163 |
| measured | 0.24% | - | - | SCCP/0163 |
| measured | 1.49% | - | - | SCCS/0108 |
| measured | 0.2% | - | - | SCCS/0108 |
| default | 0.24% | - | - | SCCS/0108 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "80062-31-3", "ingredient_class": "direct_dye", "chemical_class": "nitro", "color_result_on_hair": "Orange", "shade_range": "red", "primary_function": "direct_deposit", "requires_developer": "no", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-10", "light_fastness": "moderate", "oxidation_mechanism": "direct_absorption", "hair_penetration_depth":…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Restricted for Children (Cosmetics)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 2-Nitro-5-Glyceryl Methylaniline.
Regulatory Flags
eu_children_restricted
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2-Nitro-5-Glyceryl Methylaniline by CAS number or substance name.
Studies
52
Lowest NOAEL
0.011
Highest NOAEL
800
Units vary across source rows: mg/kg bw/day, mg/kg/day, mg/kg bw
SCCS_vision_codex
SCCNFP_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.2% | - | - |
| 0.24% | - | - |
| 1.49% | - | - |
| 0.2% | - | - |
| 0.24% | - | - |
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
children; Europe; Personal care
children; Europe; Personal care
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 2-Nitro-5-Glyceryl Methylaniline allowed in the EU?
2-Nitro-5-Glyceryl Methylaniline EU regulatory status: prohibited. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Nitro-5-Glyceryl Methylaniline do in cosmetics?
2-Nitro-5-Glyceryl Methylaniline functions as: Non-oxidative (semi-permanent) hair dye. It is classified as a cosmetic ingredient in our database. CAS number: 80062-31-3.
What is the NOAEL for 2-Nitro-5-Glyceryl Methylaniline?
The NOAEL (No Observed Adverse Effect Level) for 2-Nitro-5-Glyceryl Methylaniline is =100 mg/kg bw/day based on a repeated dose toxicity study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Is 2-Nitro-5-Glyceryl Methylaniline used outside cosmetics?
2-Nitro-5-Glyceryl Methylaniline also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Nitro-5-Glyceryl Methylaniline have different safety status in cosmetics vs industrial chemicals?
2-Nitro-5-Glyceryl Methylaniline is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302).
Compliance Tools
Check 2-Nitro-5-Glyceryl Methylaniline compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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