NOAEL Studies Cosmetic Ingredient

2-Nitro-P-Phenylenediamine NOAEL Studies

INCI: 2-NITRO-P-PHENYLENEDIAMINE

CAS: 5307-14-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1992 IARC Monographs {"additional_info":"volume_publication_year=1993","evaluation_year":1992,"source_table":"iarc_classifications","volume":"Sup 7, 57"}
NTP_ICE_acute_oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1800 mg/kg bw Rat (Male/Female) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7206; row=6972; data_type=In Vivo; mixture=Chemical; chemical_name=2-Nitro-1,4-phenylenediamine; preferred_name=2-Nitro-1,4-phenylenediamine; dtxsid=DTXSID4020957; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4020957; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2100 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7207; row=6973; data_type=In Vivo; mixture=Chemical; chemical_name=2-Nitro-1,4-phenylenediamine; preferred_name=2-Nitro-1,4-phenylenediamine; dtxsid=DTXSID4020957; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4020957; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =3080 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7208; row=6974; data_type=In Vivo; mixture=Chemical; chemical_name=2-Nitro-1,4-phenylenediamine; preferred_name=2-Nitro-1,4-phenylenediamine; dtxsid=DTXSID4020957; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4020957; source_file=acute_oral.xlsx
NTP_ICE_cancer 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=4522; Record_ID=cancer_1998; Data_Type=WOE; Formulation_Name=2-Nitro-1,4-phenylenediamine; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/75; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_cancer Top dose 1100 ppm Rat - - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=4519; Record_ID=cancer_1993; Data_Type=In Vivo; Formulation_Name=2-Nitro-p-phenylenediamine; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1100; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Reference=TR-169; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr169/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_cancer Top dose 2200 ppm Rat - - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=4520; Record_ID=cancer_1994; Data_Type=In Vivo; Formulation_Name=2-Nitro-p-phenylenediamine; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2200; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Reference=TR-169; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr169/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_cancer Top dose 4400 ppm Mouse - - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=4521; Record_ID=cancer_1996; Data_Type=In Vivo; Formulation_Name=2-Nitro-p-phenylenediamine; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=4400; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Reference=TR-169; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr169/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization 19 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CD54, EC200 276.7 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1968; Record_ID=skin_sensitization_invitro_497; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=276.7; Reported_Response_Unit=ug/mL; Response=276.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization CD86, EC150 6.8 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8315; Record_ID=skin_sensitization_invitro_2305; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=44.4038135; Reported_Response_Unit=uM; Conversion_Factor_Value=153.141; Conversion_Factor_Source=EPA Dashboard; Converted_Response=6.8; Converted_Response_Unit=ug/mL; Response=6.8; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization CD86, EC150 5.42 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8508; Record_ID=skin_sensitization_invitro_2345; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=5.42; Reported_Response_Unit=ug/mL; Response=5.42; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization CV70 115.49 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8507; Record_ID=skin_sensitization_invitro_2345; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=U-SENS; Endpoint=CV70; Reported_Response=115.49; Reported_Response_Unit=ug/mL; Response=115.49; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization CV75 490.7 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1970; Record_ID=skin_sensitization_invitro_497; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=h-CLAT; Endpoint=CV75; Reported_Response=490.7; Reported_Response_Unit=ug/mL; Response=490.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization Depletion Cys 99.2 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1281; Record_ID=skin_sensitization_invitro_344; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=99.2; Reported_Response_Unit=%; Response=99.2; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization Depletion Cys 93.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1289; Record_ID=skin_sensitization_invitro_346; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=93.3; Reported_Response_Unit=%; Response=93.3; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization Depletion Lys 5.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1280; Record_ID=skin_sensitization_invitro_344; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=5.7; Reported_Response_Unit=%; Response=5.7; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization Depletion Lys 0 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1287; Record_ID=skin_sensitization_invitro_346; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization Depletion Lys + Cys 50 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1284; Record_ID=skin_sensitization_invitro_344; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=50; Reported_Response_Unit=%; Response=50; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization Depletion Lys + Cys 46.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1291; Record_ID=skin_sensitization_invitro_346; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=46.7; Reported_Response_Unit=%; Response=46.7; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization EC1.5 11.464 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5875; Record_ID=skin_sensitization_invitro_1384; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=11.464; Reported_Response_Unit=uM; Response=11.464; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization EC3 786.4 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5876; Record_ID=skin_sensitization_invitro_1384; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=786.41600000000005; Reported_Response_Unit=uM; Response=786.4; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization EC3 0.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13484; Record_ID=skin_sensitization_invivo_3677; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=LLNA; Endpoint=EC3; Response=0.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization EC3 0.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13484; Record_ID=skin_sensitization_invivo_3677; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=LLNA; Endpoint=EC3; Response=0.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization EC3 0.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13484; Record_ID=skin_sensitization_invivo_3677; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=LLNA; Endpoint=EC3; Response=0.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization EC3 0.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13484; Record_ID=skin_sensitization_invivo_3677; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=LLNA; Endpoint=EC3; Response=0.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization IC50 >2000 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5877; Record_ID=skin_sensitization_invitro_1384; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=KeratinoSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
NTP_ICE_skin_sensitization Imax 4.53 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5878; Record_ID=skin_sensitization_invitro_1384; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4020957; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=4.53; Reported_Response_Unit=Unitless; Response=4.53; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020957; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020957
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier PV83F3C01Q UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7N3O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"PV83F3C01Q"}
openFDA substances FDA UNII substance identifier PV83F3C01Q UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7N3O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"PV83F3C01Q"}
openFDA substances FDA UNII substance identifier PV83F3C01Q UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7N3O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"PV83F3C01Q"}
openFDA substances FDA UNII substance identifier PV83F3C01Q UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7N3O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"PV83F3C01Q"}