NOAEL Studies Cosmetic Ingredient

2-Tert-Butylhydroquinone Methyl Ether NOAEL Studies

INCI: 2-TERT-BUTYLHYDROQUINONE METHYL ETHER

CAS: 121-00-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =4000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1655; row=12446; data_type=In Vivo; mixture=Chemical; chemical_name=2-tert-Butyl-4-methoxyphenol; preferred_name=2-tert-Butyl-4-methoxyphenol; dtxsid=DTXSID7040788; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7040788; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2910 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_1652; row=12447; data_type=In Vivo; mixture=Chemical; chemical_name=2-tert-Butyl-4-methoxyphenol; preferred_name=2-tert-Butyl-4-methoxyphenol; dtxsid=DTXSID7040788; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7040788; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 7.06 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2968; Record_ID=adme_parameters_289; Data_Type=Measured; DTXSID=DTXSID7040788; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=7.06; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7040788
NTP_ICE_adme_parameters Fu 0.07217 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2969; Record_ID=adme_parameters_289; Data_Type=Measured; DTXSID=DTXSID7040788; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.07217; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7040788
NTP_ICE_endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 53.0811678218426 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=2792; RecordID=ERPathway2016_369; DatasetName=ERPathway2016; DTXSID=DTXSID7040788; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=53.0811678218426; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7040788
NTP_ICE_endocrine ACC 34.3137252443965 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=2793; RecordID=ERPathway2016_369; DatasetName=ERPathway2016; DTXSID=DTXSID7040788; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=34.3137252443965; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7040788
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=2788; RecordID=ARPathway2016_682; DatasetName=ARPathway2016; DTXSID=DTXSID7040788; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7040788
NTP_ICE_endocrine Model Score 0.0139 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=2794; RecordID=ERPathway2016_369; DatasetName=ERPathway2016; DTXSID=DTXSID7040788; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0139; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7040788
ToxValDB_ECHA_IUCLID 34 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =100 mg/kg bw/day Hamster oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c805e4b0a7c65d2162e4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/8?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818377_15818378_15818518_15818519_15819101:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1c20b5bce1342a6dc8f4b76c49a619d5
ToxValDB_ECHA_IUCLID LOAEL ~750 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b3087; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/8?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820530_15820532_15820541_15820565:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1577341de228ed078806e8f93077486b
ToxValDB_ECHA_IUCLID LOAEL =500 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc6e4b0a7c65d1bbb98; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/9/3?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820596_15824114:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dbc6b3eb3437b8237fabe84ead4e9d1f
ToxValDB_ECHA_IUCLID LOAEL =300 mg/kg bw/day Rat oral short-term; 3 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca40e4b0a7c65d220f5e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/6/2?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15834785:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_273c8d496ad26957e263d3d07d7aa8cd
ToxValDB_ECHA_IUCLID LOAEL =50 mg/kg bw/day Rat injection short-term; 3 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c620e4e4b096bca8783277; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/6/5?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15854550:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_15c8860ca3b56a18d1dd6f354469b831
ToxValDB_ECHA_IUCLID LOEL ~125 mg/kg bw/day Monkey oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c805e4b0a7c65d2162ae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/8?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=organ weight and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816164_15816165:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e74e64ce4586c02f38d4d29ee07f8d6
ToxValDB_ECHA_IUCLID LOEL =36000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d199e4b0a7c65d22f41b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/9/3?documentUUID=071db83f-d7fb-4634-b201-51641874aa9e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823050_15824106:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5d2630d980944d51a25a52631832cac2
ToxValDB_ECHA_IUCLID LOEL =30000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc6e4b0a7c65d1bbb9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/9/3?documentUUID=071db83f-d7fb-4634-b201-51641874aa9e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823050_15824106:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_161a82fbe114b885baf7b0759e8ac842
ToxValDB_ECHA_IUCLID LOEL =12600 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc6e4b0a7c65d1bbb9c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/9/3?documentUUID=071db83f-d7fb-4634-b201-51641874aa9e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15824107:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3e46ff3c9479900116c701dad09b522c
ToxValDB_ECHA_IUCLID LOEL =15000 mg/kg bw/day Monkey oral subchronic; 84 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca40e4b0a7c65d220f63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/6/2?documentUUID=071db83f-d7fb-4634-b201-51641874aa9e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15835170:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3eed463a5d0ea0f85a37846e69671a99
ToxValDB_ECHA_IUCLID LOEL =700 mg/kg bw/day Rat oral short-term; 7 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca41e4b0a7c65d220f70; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/6/2?documentUUID=071db83f-d7fb-4634-b201-51641874aa9e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15835875:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e164de0339488026cdfd40e4ea23615d
ToxValDB_ECHA_IUCLID LOEL =14000 mg/kg bw/day Monkey oral short-term; 4 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca41e4b0a7c65d220f90; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/6/2?documentUUID=071db83f-d7fb-4634-b201-51641874aa9e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15842986:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f16bf316b4427550e0cabd051648f37d
ToxValDB_ECHA_IUCLID LOEL =3300 mg/kg bw/day Rat oral short-term; 12 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca41e4b0a7c65d220fa1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/6/2?documentUUID=071db83f-d7fb-4634-b201-51641874aa9e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15845832:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_be1ec38ccc46b271449a4b956cc643f7
ToxValDB_ECHA_IUCLID LOEL =9900 mg/kg bw/day Rat oral chronic; 16 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead05e4b0a7c65d1c219f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/6/2?documentUUID=071db83f-d7fb-4634-b201-51641874aa9e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15850532:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ca1f739349b8c01d28e497c936dd18d1
ToxValDB_ECHA_IUCLID LOEL =63000 mg/kg bw/day Rat oral subchronic; 6 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead05e4b0a7c65d1c21a3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/6/2?documentUUID=071db83f-d7fb-4634-b201-51641874aa9e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15850534:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b775d973154d0de4bc7bd68e4e6a0329
ToxValDB_ECHA_IUCLID LOEL =24500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5e3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/9/2?documentUUID=071db83f-d7fb-4634-b201-51641874aa9e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15862582:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a981aeb02c5a3497fa56c146bc45316d
ToxValDB_ECHA_IUCLID LOEL =35000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5e40; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/9/2?documentUUID=071db83f-d7fb-4634-b201-51641874aa9e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15862583:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4ff75ada8e6f53471a76eaea27f86d8f
ToxValDB_ECHA_IUCLID NOAEL <1000 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c805e4b0a7c65d2162ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/8?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816152_15816794_15816795_15817626_15817642_15818118_15818119_15819707_15820551:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d35a0042c3a7ee20ec8c0aaa708b1825
ToxValDB_ECHA_IUCLID NOAEL ~250 mg/kg bw/day Monkey oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c805e4b0a7c65d2162ae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/8?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=organ weight and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816164_15816165:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_837fcf5a4f1ec0dd6d7c068f01e0947d
ToxValDB_ECHA_IUCLID NOAEL ~500 mg/kg bw/day Monkey oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c805e4b0a7c65d2162be; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/8?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=organ weight and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816281_15816282:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca097109f97a664a6f92c0f92c374827
ToxValDB_ECHA_IUCLID NOAEL ~230 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b3085; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/8?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816152_15816794_15816795_15817626_15817642_15818118_15818119_15819707_15820551:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_29702966a43257e2bdd9e73bdd43cf77
ToxValDB_ECHA_IUCLID NOAEL <936 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c805e4b0a7c65d2162c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/8?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816152_15816794_15816795_15817626_15817642_15818118_15818119_15819707_15820551:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8f4d991a8afc799c0b1182fd08093bb0
ToxValDB_ECHA_IUCLID NOAEL <1200 mg/kg bw/day Hamster oral - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c805e4b0a7c65d2162d6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/8?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818377_15818378_15818518_15818519_15819101:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_070915ec8ffc5a92d3cc0327c11954ce
ToxValDB_ECHA_IUCLID NOAEL ~925 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b307f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/8?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15820547:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8b8c750d47d174c0c9003a6017848e29
ToxValDB_ECHA_IUCLID NOAEL <55 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b3085; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/8?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816152_15816794_15816795_15817626_15817642_15818118_15818119_15819707_15820551:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ad6c101e514b9b3c9d7fd61bd9db7d01
ToxValDB_ECHA_IUCLID NOAEL =120 mg/kg bw/day Hamster oral - developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d199e4b0a7c65d22f413; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/9/3?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15820892:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d29f19851afbb2b29f574b4115f9dc37
ToxValDB_ECHA_IUCLID NOAEL =400 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc6e4b0a7c65d1bbba0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/9/3?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15824108:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1d11459352b3068b9b9b2119c809f914
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rat oral - developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc6e4b0a7c65d1bbba4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/9/3?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15824111:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d595de6cf152e62e555244d685f27a92
ToxValDB_ECHA_IUCLID NOAEL =225 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc6e4b0a7c65d1bbba8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/9/3?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821952_15824113:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f3aed9838bbd1a49014845ad5ed0bbe2
ToxValDB_ECHA_IUCLID NOAEL =50 mg/kg bw/day Rat oral short-term; 10 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca41e4b0a7c65d220f7a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/6/2?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15842155:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e3afa62712131dd749d221cc1adc27e5
ToxValDB_ECHA_IUCLID NOEL =750 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc6e4b0a7c65d1bbb9e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/9/3?documentUUID=071db83f-d7fb-4634-b201-51641874aa9e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822292_15824112:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fac39a1c14853a6fb38ea669ccfc1ea6
ToxValDB_ECHA_IUCLID NOEL =350 mg/kg bw/day Rat oral chronic; 240 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead05e4b0a7c65d1c21ad; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/6/2?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15850536:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9653d18d9e2d97d61c8a7ee05b25a05b
ToxValDB_ECHA_IUCLID NOEL =10 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5e38; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/9/2?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856137_15862580:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9245e102b87cac394ad10208917d1780
ToxValDB_ECHA_IUCLID NOEL >50 mg/kg bw/day Pig oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c89fe4b0a7c65d2196dc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15988/7/9/2?documentUUID=ecb52cec-0bec-4722-8635-84d5fcf3e025; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855829_15856576:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9b09298ea7a7922dbbb8bbe60cf1f9ee
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =4.93 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635057_15635058:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c4dfab4d8fcf1117c70ce650b2a230b4
ToxValDB_GESTIS_DNEL DNEL systemic =3.112 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635057_15635058:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3485b3a106d5297374ba7612acee35df
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 62RAC24292 UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"62RAC24292"}
openFDA substances FDA UNII substance identifier 62RAC24292 UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"62RAC24292"}
openFDA substances FDA UNII substance identifier 62RAC24292 UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"62RAC24292"}
openFDA substances FDA UNII substance identifier 62RAC24292 UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"62RAC24292"}