NOAEL Studies Cosmetic Ingredient

2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate NOAEL Studies

INCI: 2,3-DIAMINODIHYDROPYRAZOLO PYRAZOLONE DIMETHOSULFONATE

CAS: 857035-95-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.03 mg/kg bw/d rat oral 90 day dermal absorption p.25
SCCS Opinion NOAEL =300 mg/kg bw/day - - - NOAEL study p.19
SCCS Opinion NOAEL =300 mg/kg bw/d rat oral 90 day dermal absorption p.25
SCCS Opinion NOAEL =1000 mg/kg bw/day - - developmental developmental toxicity Ref.: 11 Comment, p.24
ECHA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23de4b0a7c65d232241; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/3841/7/9/3?documentUUID=ea9c35a5-a10d-4983-8c96-0cde50824c78; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15822034:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_18458c75eba60860cd6f74983086f354
ECHA NOAEL =300 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf31e4b0a7c65d1ccf01; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/3841/7/6/2?documentUUID=ea9c35a5-a10d-4983-8c96-0cde50824c78; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15837409:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4dd97b06daf2f3213b789374ae07d362
ECHA NOAEL =1000 mg/kg bw/day Rat oral short-term; 15 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbffe4b0a7c65d2287d5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/3841/7/6/2?documentUUID=ea9c35a5-a10d-4983-8c96-0cde50824c78; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15844132:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_36a25dc2a19bb8000b60d7e4dd316c59
Regulatory source 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 300 mg/kg bw/day - - - - p.19
Regulatory source - 300 mg/kg bw/day rat oral - - p.26
Regulatory source dermal absorption =0.03 mg/kg bw/d rat oral 90 day dermal absorption p.25
Regulatory source dermal absorption =300 mg/kg bw/d rat oral 90 day dermal absorption p.25
Regulatory source developmental toxicity 300 mg/kg bw/day rabbit - 90-day developmental toxicity p.26
Regulatory source developmental toxicity 1000 mg/kg bw/day - - developmental developmental toxicity p.24
Regulatory source developmental toxicity 1000 mg/kg bw/day rabbit - 90-day developmental toxicity p.26
Regulatory source repeated dose toxicity 300 mg/kg bw/day - - 90-day repeated dose toxicity p.25
Regulatory source repeated dose toxicity 1000 mg/kg bw/day human - 90-day repeated dose toxicity p.25
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier S409QAZ004 UNII - - - chemical -