NOAEL Studies Cosmetic Ingredient

2,3,6-Trimethylphenol NOAEL Studies

INCI: 2,3,6-TRIMETHYLPHENOL

CAS: 2416-94-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE adme parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 106 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2387; Record_ID=adme_parameters_836; Data_Type=Measured; DTXSID=DTXSID6022187; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=106.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022187
NTP ICE adme parameters Fu 0.0908 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2388; Record_ID=adme_parameters_836; Data_Type=Measured; DTXSID=DTXSID6022187; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0908; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022187
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=1656; RecordID=ARPathway2016_1031; DatasetName=ARPathway2016; DTXSID=DTXSID6022187; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022187
ECHA 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =300 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eade1e4b0a7c65d1c6759; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1874/7/6/2?documentUUID=b7f79b34-b2fb-4f91-83d8-bd12f3bb7d24; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831986_15831987:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f62406a71f5760b8e6749edb254d4efa
ECHA LOAEL ~1346 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eade1e4b0a7c65d1c6761; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1874/7/6/2?documentUUID=b7f79b34-b2fb-4f91-83d8-bd12f3bb7d24; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839434_15839436:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_da0994386a168f9d5f34a130661774d3
ECHA NOAEL =100 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eade1e4b0a7c65d1c6759; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1874/7/6/2?documentUUID=b7f79b34-b2fb-4f91-83d8-bd12f3bb7d24; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831986_15831987:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2fd6c782cce79c75f60303e6576e7668
ECHA NOAEL ~273 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eade1e4b0a7c65d1c6761; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1874/7/6/2?documentUUID=b7f79b34-b2fb-4f91-83d8-bd12f3bb7d24; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain|haematology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839434_15839436:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9443ca663db1b960fb851b96b5a8fd1a
ECHA NOAEL ~55 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eade1e4b0a7c65d1c6761; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1874/7/6/2?documentUUID=b7f79b34-b2fb-4f91-83d8-bd12f3bb7d24; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain|haematology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839435_15839437:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_114fd4504d9c2873a62306058a2ec590
ToxValDB ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX NOEL =1000 mM Mouse dermal short-term; 8 days short-term LONG_REF=Toxicology232(1-2): 132-137 Yamano,T., M. Ichihara, M. Shimizu, T. Noda, and Y. Tsujimoto Immunomodulatory Effects of Mono-, di-, and Trimethylphenols in Mice 2007; TITLE=Immunomodulatory Effects of Mono-, di-, and Trimethylphenols in Mice; AUTHOR=Yamano,T., M. Ichihara, M. Shimizu, T. Noda, and Y. Tsujimoto; DOI=10.1016/j.tox.2006.12.021; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=115071; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Immunological: Lymphocyte activity; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECOTOX:15604838:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=158e01a055fad41f76895727ba3b02c5
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =9.79 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635508_15635509:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6c35394588abda5b3c04b0262826639e
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 05WKL2L5LJ UNII - - - chemical -