NOAEL Studies
Cosmetic Ingredient
2,3,6-Trimethylphenol NOAEL Studies
INCI: 2,3,6-TRIMETHYLPHENOL
CAS: 2416-94-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_adme_parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 106 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2387; Record_ID=adme_parameters_836; Data_Type=Measured; DTXSID=DTXSID6022187; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=106.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022187 |
| NTP_ICE_adme_parameters | Fu | 0.0908 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2388; Record_ID=adme_parameters_836; Data_Type=Measured; DTXSID=DTXSID6022187; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0908; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022187 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1656; RecordID=ARPathway2016_1031; DatasetName=ARPathway2016; DTXSID=DTXSID6022187; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022187 |
ToxValDB_ECHA_IUCLID 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =300 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eade1e4b0a7c65d1c6759; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1874/7/6/2?documentUUID=b7f79b34-b2fb-4f91-83d8-bd12f3bb7d24; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831986_15831987:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f62406a71f5760b8e6749edb254d4efa |
| ToxValDB_ECHA_IUCLID | LOAEL | ~1346 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eade1e4b0a7c65d1c6761; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1874/7/6/2?documentUUID=b7f79b34-b2fb-4f91-83d8-bd12f3bb7d24; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839434_15839436:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_da0994386a168f9d5f34a130661774d3 |
| ToxValDB_ECHA_IUCLID | NOAEL | =100 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eade1e4b0a7c65d1c6759; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1874/7/6/2?documentUUID=b7f79b34-b2fb-4f91-83d8-bd12f3bb7d24; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831986_15831987:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2fd6c782cce79c75f60303e6576e7668 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~273 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eade1e4b0a7c65d1c6761; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1874/7/6/2?documentUUID=b7f79b34-b2fb-4f91-83d8-bd12f3bb7d24; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain|haematology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839434_15839436:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9443ca663db1b960fb851b96b5a8fd1a |
| ToxValDB_ECHA_IUCLID | NOAEL | ~55 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eade1e4b0a7c65d1c6761; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1874/7/6/2?documentUUID=b7f79b34-b2fb-4f91-83d8-bd12f3bb7d24; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=body weight and weight gain|haematology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839435_15839437:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_114fd4504d9c2873a62306058a2ec590 |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =1000 | mM | Mouse | dermal | short-term; 8 days | short-term | LONG_REF=Toxicology232(1-2): 132-137 Yamano,T., M. Ichihara, M. Shimizu, T. Noda, and Y. Tsujimoto Immunomodulatory Effects of Mono-, di-, and Trimethylphenols in Mice 2007; TITLE=Immunomodulatory Effects of Mono-, di-, and Trimethylphenols in Mice; AUTHOR=Yamano,T., M. Ichihara, M. Shimizu, T. Noda, and Y. Tsujimoto; DOI=10.1016/j.tox.2006.12.021; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=115071; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Immunological: Lymphocyte activity; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECOTOX:15604838:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=158e01a055fad41f76895727ba3b02c5 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =9.79 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635508_15635509:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6c35394588abda5b3c04b0262826639e |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 05WKL2L5LJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"05WKL2L5LJ"} |
| openFDA substances | FDA UNII substance identifier | 05WKL2L5LJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"05WKL2L5LJ"} |
| openFDA substances | FDA UNII substance identifier | 05WKL2L5LJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"05WKL2L5LJ"} |
| openFDA substances | FDA UNII substance identifier | 05WKL2L5LJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"05WKL2L5LJ"} |