NOAEL Studies Cosmetic Ingredient

2,4-Diaminophenoxyethanol HCl NOAEL Studies

INCI: 2,4-DIAMINOPHENOXYETHANOL HCL

CAS: 66422-95-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS DB 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 20 mg/kg bw/day rat oral 90 day Subchronic SCCS; G. Chevalier. 2,4 diaminophenoxyethanol HCl (A042): 13-Week Toxicity Study by oralRoute (Gavage) in Rats followed by a 4-Week Treatment-free Period. CIT StudyNo. 26892 TCR, 2005
COSMOS DB LOAEL 125 mg/kg bw/day rat oral 6-19 Gestation day Developmental SCCS; W. Gaoua. 2,4 diaminophenoxyethanol HCl (A042): prenatal developmental ToxicityStudy by oral Route (Gavage) in Rats. CIT Study No. 26891 RSR, 2005
COSMOS DB NOAEL 4 mg/kg bw/day rat oral 90 day Subchronic SCCS; G. Chevalier. 2,4 diaminophenoxyethanol HCl (A042): 13-Week Toxicity Study by oralRoute (Gavage) in Rats followed by a 4-Week Treatment-free Period. CIT StudyNo. 26892 TCR, 2005
COSMOS DB NOAEL 20 mg/kg bw/day rat oral 6-19 Gestation day Developmental SCCS; W. Gaoua. 2,4 diaminophenoxyethanol HCl (A042): prenatal developmental ToxicityStudy by oral Route (Gavage) in Rats. CIT Study No. 26891 RSR, 2005
NTP ICE skin sensitization 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization EC3 5.5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13080; Record_ID=skin_sensitization_invivo_3075; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID3070462; Assay=LLNA; Endpoint=EC3; Response=5.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3070462
SCCS Opinion 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.051 mg/kg rat oral 13 week developmental toxicity p.24
SCCS Opinion NOAEL =20 mg/kg/day - - 4-week NOAEL study p.15
SCCS Opinion NOAEL =20 mg/kg rat oral 13 week developmental toxicity p.24
ECHA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =20 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae98e4b0a7c65d1ca155; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10194/7/6/2?documentUUID=c0dfd8ed-26ea-4cf5-b089-b03309603654; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=body weight and weight gain|gross pathology|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|urinalysis; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834528_15841006:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc56a34ac8693bda3c6937e626b5dfff
ECHA NOEL =20 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be5dc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10194/7/9/3?documentUUID=c0dfd8ed-26ea-4cf5-b089-b03309603654; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820582_15821849:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_32e4b0d468601fbda78d86d4db9f2324
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =0.7 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630976:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9db025a652da4daa69bdb90d84554190
Regulatory source 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 20 mg/kg/day - - 4-week - p.15
Regulatory source - 20 mg/kg/day human - - - p.23
Regulatory source developmental toxicity =0.051 mg/kg rat oral 13 week developmental toxicity p.24
Regulatory source developmental toxicity =20 mg/kg rat oral 13 week developmental toxicity p.24
Regulatory source developmental toxicity 20 mg/kg bw/day rat oral 13 week developmental toxicity p.24
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier Z5Y843J6KQ UNII - - - chemical -