NOAEL Studies Cosmetic Ingredient

2,6-Dihydroxy-3,4-Dimethylpyridine NOAEL Studies

INCI: 2,6-DIHYDROXY-3,4-DIMETHYLPYRIDINE

CAS: 84540-47-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 160 mg/kg bw/day rat oral 6-20 Gestation day Developmental SCCP; Marburger, A. and Flade, D. (2005). Prenatal developmental toxicity study in the Han Wistar rat. RCC Ltd, Itingen, Switzerland, internal study code 854665. Archive code at Henkel KGaA, Düsseldorf, Report No. R 0500122
COSMOS DB NOAEL 80 mg/kg bw/day rat oral 6-20 Gestation day Developmental SCCP; Marburger, A. and Flade, D. (2005). Prenatal developmental toxicity study in the Han Wistar rat. RCC Ltd, Itingen, Switzerland, internal study code 854665. Archive code at Henkel KGaA, Düsseldorf, Report No. R 0500122
SCCS Opinion 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.017 mg/kg rat oral - dermal absorption p.21
SCCS Opinion NOAEL =80 mg/kg human oral - developmental toxicity p.20
SCCS Opinion NOAEL =100 mg/kg bw rat - Chronic genotoxicity p.15
SCCS Opinion NOAEL =100 mg/kg rabbit oral 90 days dermal absorption p.21
SCCS Opinion NOAEL =1000 mg/kg - oral Sub-chronic repeated dose toxicity p.14
Regulatory source 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source dermal absorption =0.017 mg/kg rat oral - dermal absorption p.21
Regulatory source dermal absorption =80 mg/kg rat oral - dermal absorption p.21
Regulatory source dermal absorption 80 mg/kg rabbit oral 90 days dermal absorption p.21
Regulatory source dermal absorption 100 mg/kg rabbit oral 90 days dermal absorption p.21
Regulatory source developmental toxicity 80 mg/kg human oral - developmental toxicity p.20
Regulatory source genotoxicity 100 mg/kg bw rat - Chronic genotoxicity p.15
Regulatory source repeated dose toxicity 1000 mg/kg - oral Sub-chronic repeated dose toxicity p.14
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3VDO3A5MTW UNII - - - chemical -