NOAEL Studies Cosmetic Ingredient

2,6-Dihydroxyethylaminotoluene NOAEL Studies

INCI: 2,6-DIHYDROXYETHYLAMINOTOLUENE

CAS: 149330-25-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 100 mg/kg bw/day rat oral 90 day Subchronic SCCS; Hruby, R. 90-day toxicity study with “WSI-111” in rats. ÖsterreichischesForschungszentrum Seibersdorf, Seibersdor f, Austria, internal study code: SON7. Archive code at Henkel KGaA, Düsseldorf, Report No. R 9601546
SCCNFP Opinion 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =100 mg/kg bw/day - dermal Sub-chronic repeated dose toxicity Ref. : 5 2, p.7
SCCNFP Opinion NOAEL =100 mg/kg rat oral 13 weeks dermal absorption p.18
SCCNFP Opinion NOAEL =100 mg/kg bw rat oral 13 weeks sensitisation p.18
SCCNFP Opinion NOAEL =200 mg/kg bw - - - NOAEL study Ref. : 14, p.9
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =100 mg/kg bw/d - - Chronic genotoxicity p.15
SCCS Opinion NOAEL =200 mg/kg bw rat oral - NOAEL study p.21
SCCS Opinion NOAEL =0 mg/kg bw rat oral 90 day reproductive toxicity p.24
SCCS Opinion NOAEL =200 mg/kg bw/d rat oral 90 day reproductive toxicity p.24
SCCS Opinion NOAEL =0.036 mg/kg bw/d rat oral 90-day dermal absorption p.26
SCCS Opinion NOAEL =84 mg/kg bw/d rat oral 90-day dermal absorption p.26
Regulatory source 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 100 mg/kg rat oral 13 weeks - p.18
Regulatory source - 200 mg/kg bw - - - - p.9
Regulatory source dermal absorption =100 mg/kg rat oral 13 weeks dermal absorption p.18
Regulatory source repeated dose toxicity 100 mg/kg bw/day - dermal Sub-chronic repeated dose toxicity p.7
Regulatory source sensitisation 100 mg/kg bw rat oral 13 weeks sensitisation p.18
Regulatory source sensitisation 200 mg/kg bw rat oral 90 day sensitisation p.18
Regulatory source - 200 mg/kg bw rat oral - - p.21
Regulatory source dermal absorption =0.036 mg/kg bw/d rat oral 90-day dermal absorption p.26
Regulatory source dermal absorption =100 mg/kg bw/d rat oral 90-day dermal absorption p.26
Regulatory source dermal absorption =84 mg/kg bw/d rat oral 90-day dermal absorption p.26
Regulatory source genotoxicity 100 mg/kg bw/d - - Chronic genotoxicity p.15
Regulatory source reproductive toxicity 0 mg/kg bw rat oral 90 day reproductive toxicity p.24
Regulatory source reproductive toxicity 200 mg/kg bw/d rat oral 90 day reproductive toxicity p.24
Regulatory source reproductive toxicity 0 mg/kg bw rat oral 90-day reproductive toxicity p.27
Regulatory source reproductive toxicity 200 mg/kg bw/d rat oral 90-day reproductive toxicity p.27
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier I50F7J73SU UNII - - - chemical -