NOAEL Studies Cosmetic Ingredient

2,6-Dimethoxy-3,5-Pyridinediamine HCl NOAEL Studies

INCI: 2,6-DIMETHOXY-3,5-PYRIDINEDIAMINE HCL

CAS: 56216-28-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 15 mg/kg bw/day rat oral 90 day Subchronic SCCP; Jones, J. R.; Pyridinblau I / OEDC 408 90-day oral toxicity study in the rat; SAFEPHARM;09.04.1986
COSMOS DB NOAEL 5 mg/kg bw/day rat oral 90 day Subchronic SCCP; Jones, J. R.; Pyridinblau I / OEDC 408 90-day oral toxicity study in the rat; SAFEPHARM;09.04.1986
NTP ICE skin sensitization 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization EC3 6.9 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13079; Record_ID=skin_sensitization_invivo_3074; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID10892438; Assay=LLNA; Endpoint=EC3; Response=6.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID10892438
SCCS Opinion 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =5 mg/kg human dermal 90 day dermal absorption p.20
SCCS Opinion NOAEL =10 mg/kg bw rabbit dermal 90 day dermal absorption p.20
SCCS Opinion NOAEL =45 mg/kg bw - - - NOAEL study p.19
Regulatory source 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 45 mg/kg bw - - - - p.19
Regulatory source dermal absorption =5 mg/kg human dermal 90 day dermal absorption p.20
Regulatory source dermal absorption 10 mg/kg bw rabbit dermal 90 day dermal absorption p.20
Regulatory source dermal absorption 45 mg/kg bw rabbit dermal 90 day dermal absorption p.20
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier H109UIY001 UNII - - - chemical -