NOAEL Studies
Cosmetic Ingredient
3-Ethoxy-1,1,5-Trimethylcyclohexane NOAEL Studies
INCI: 3-ETHOXY-1,1,5-TRIMETHYLCYCLOHEXANE
CAS: 67583-77-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9327; Record_ID=skin_sensitization_invivo_2066; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1052872; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 2000; Not available; 10.1016/S0278-6915(00)80065-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1052872 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 1350 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9326; Record_ID=skin_sensitization_invivo_2066; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1052872; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1350; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 2000; Not available; 10.1016/S0278-6915(00)80065-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1052872 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9329; Record_ID=skin_sensitization_invivo_2066; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1052872; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 2000; Not available; 10.1016/S0278-6915(00)80065-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1052872 |
ToxValDB_ECHA_IUCLID 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =500 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab28e4b0a7c65d1b922b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/18903?documentUUID=7cde891a-43e5-41f6-8667-066277cd2c85; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15857332:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4f9c3db09de2d9ca06502399fdb04a0e |