Is 3-Ethoxy-1,1,5-Trimethylcyclohexane safe in cosmetics?
3-Ethoxy-1,1,5-Trimethylcyclohexane has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
3-Ethoxy-1,1,5-Trimethylcyclohexane
Also known as: Herbavert, Cyclohexane, 3-ethoxy-1,1,5-trimethyl-, Ether, ethyl 3,3,5-trimethylcyclohexyl, 3,3,5-Trimethylcyclohexyl ethyl ether, EINECS 266-722-5 (+1 more)
INCI: 3-ETHOXY-1,1,5-TRIMETHYLCYCLOHEXANE
3-Ethoxy-1,1,5-Trimethylcyclohexane (CAS 67583-77-1) is a cosmetic cosmetic ingredient functioning as Fragrance with herbal character. NOAEL 729 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 67583-77-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance with herbal character
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3-ethoxy-1,1,5-trimethylcyclohexane
InChIKey
JVBNHJDWWBSWLE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; no specific FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3-Ethoxy-1,1,5-Trimethylcyclohexane.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 3-Ethoxy-1,1,5-Trimethylcyclohexane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =500 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 3-Ethoxy-1,1,5-Trimethylcyclohexane across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1350 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for 3-Ethoxy-1,1,5-Trimethylcyclohexane.
Regulatory Flags
fragrance-component
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 3-Ethoxy-1,1,5-Trimethylcyclohexane by CAS number or substance name.
Studies
7
Lowest NOAEL
500 mg/kg bw/day
Highest NOAEL
729 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Herbavert
Cyclohexane, 3-ethoxy-1,1,5-trimethyl-
Ether, ethyl 3,3,5-trimethylcyclohexyl
3,3,5-Trimethylcyclohexyl ethyl ether
EINECS 266-722-5
Ethyl 3,3,5-trimethylcyclohexyl ether
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 3-Ethoxy-1,1,5-Trimethylcyclohexane allowed in the EU?
3-Ethoxy-1,1,5-Trimethylcyclohexane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 3-Ethoxy-1,1,5-Trimethylcyclohexane do in cosmetics?
3-Ethoxy-1,1,5-Trimethylcyclohexane functions as: Fragrance with herbal character. It is classified as a cosmetic ingredient in our database. CAS number: 67583-77-1.
What is the NOAEL for 3-Ethoxy-1,1,5-Trimethylcyclohexane?
The NOAEL (No Observed Adverse Effect Level) for 3-Ethoxy-1,1,5-Trimethylcyclohexane is =500 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is 3-Ethoxy-1,1,5-Trimethylcyclohexane used outside cosmetics?
3-Ethoxy-1,1,5-Trimethylcyclohexane also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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