NOAEL Studies Cosmetic Ingredient

3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate NOAEL Studies

INCI: 3-HYDROXY-2,2-DIMETHYLPROPYL HYDROXYPIVALATE

CAS: 1115-20-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bbaba; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11791/7/9/3?documentUUID=bdb6907c-bccb-46ff-ac05-60325ba21ee0; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15821024:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_76419c97f5e00371d4056ec266ac7cd4
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat oral chronic; 92 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eace1e4b0a7c65d1c1590; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11791/7/6/2?documentUUID=bdb6907c-bccb-46ff-ac05-60325ba21ee0; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15831694:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f92cd70185c972c3bcb20d82f66537c
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =10.45 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632743:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_99ea5339233c7302200a1f67151d9869
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier CG0A37GAHJ UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H20O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"CG0A37GAHJ"}
openFDA substances FDA UNII substance identifier CG0A37GAHJ UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H20O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"CG0A37GAHJ"}
openFDA substances FDA UNII substance identifier CG0A37GAHJ UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H20O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"CG0A37GAHJ"}
openFDA substances FDA UNII substance identifier CG0A37GAHJ UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H20O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"CG0A37GAHJ"}