Also known as: Neopental glycol monohydroxypivalate, Propanoic acid, 3-hydroxy-2,2-dimethyl-, 3-hydroxy-2,2-dimethylpropyl ester, EINECS 214-222-2, Esterdiol 204, Hydracrylic acid, 2,2-dimethyl-, 3-hydroxy-2,2-dimethylpropyl ester (+6 more)
INCI: 3-HYDROXY-2,2-DIMETHYLPROPYL HYDROXYPIVALATE
3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate (CAS 1115-20-4) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent; humectant and emollient; polyol intermediate. Reported NOAEL =300 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate is classified GHS Danger (H318, H319) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate.
Calculate MoS for your specific formulation with the MoS Calculator.
2 study endpoints found for 3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | oral | Rat | chronic | ECHA |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | developmental | ECHA |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Preliminary editorial summary for 3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to 3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate functions as: Skin conditioning agent; humectant and emollient; polyol intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 1115-20-4.
The NOAEL (No Observed Adverse Effect Level) for 3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate is =300 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ECHA.
3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate is classified GHS Danger (H318, H319) in the chemicals database but is allowed in EU cosmetics.
Check 3-Hydroxy-2,2-Dimethylpropyl Hydroxypivalate compliance across multiple jurisdictions:
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