3-Hydroxybutyric Acid

INCI: 3-HYDROXYBUTYRIC ACID

CAS Number
300-85-6 (racemic DL); 625-72-9 (R); 6168-83-8 (S)
Function
Anti-sebum, Humectant, Plasticiser
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not restricted by FDA; no specific monograph; permitted for cosmetic use under general FDCA provisions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

pH-dependent skin irritation at high concentrations; recommend formulation pH โ‰ฅ 3.5

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Concern Level: Low

Frequently Asked Questions

Is 3-Hydroxybutyric Acid safe in cosmetics?

pH-dependent skin irritation at high concentrations; recommend formulation pH โ‰ฅ 3.5 The EU classifies 3-Hydroxybutyric Acid as "permitted". Safety rating: GOOD.

Is 3-Hydroxybutyric Acid allowed in the EU?

3-Hydroxybutyric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 3-Hydroxybutyric Acid do in cosmetics?

3-Hydroxybutyric Acid functions as: Anti-sebum, Humectant, Plasticiser. It is classified as a cosmetic ingredient in our database. CAS number: 300-85-6 (racemic DL); 625-72-9 (R); 6168-83-8 (S).

What is the Margin of Safety for 3-Hydroxybutyric Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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