Excellent Cosmetic Ingredient NOAEL Data

Alanyl Glutamine

INCI: ALANYL GLUTAMINE

CAS Number
39537-23-0
Function
Skin conditioning, humectant
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific FDA restriction. Used extensively in parenteral nutrition (IV-grade), indicating high systemic safety.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Alanyl Glutamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 833 mg/kg bw/day oral rat oral REACH
NOAEL 3259.4 mg/kg bw/day oral rat oral REACH
NOAEL 3129 mg/kg bw/day oral rat oral REACH

Expert Verdict

One of the safest profiles on this list.

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Concern Level: None

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is Alanyl Glutamine safe in cosmetics?

One of the safest profiles on this list. The EU classifies Alanyl Glutamine as "permitted". Safety rating: EXCELLENT. 3 toxicological study endpoint(s) are available in our database.

Is Alanyl Glutamine allowed in the EU?

Alanyl Glutamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Alanyl Glutamine do in cosmetics?

Alanyl Glutamine functions as: Skin conditioning, humectant. It is classified as a cosmetic ingredient in our database. CAS number: 39537-23-0.

What is the Margin of Safety for Alanyl Glutamine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Alanyl Glutamine?

The NOAEL (No Observed Adverse Effect Level) for Alanyl Glutamine is 833 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

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