3-Methylamino-4-Nitrophenoxyethanol
INCI: 3-METHYLAMINO-4-NITROPHENOXYETHANOL
Regulatory Status
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Safety Data
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Expert Verdict
Secondary amine prone to nitrosation; must not be combined with nitrosating substances and nitrosamine content must be < 50 ppb. LD50 between 1,000–2,000 mg/kg (oral, rat). At 400 mg/kg/day in 90-day study: cataracts, renal tubular nephrosis, thymic lymphoid depletion. SCCP lowered NOAEL to 25 mg/kg/day due to thymic depletion at 100 mg/kg.
Frequently Asked Questions
Is 3-Methylamino-4-Nitrophenoxyethanol safe in cosmetics?
Secondary amine prone to nitrosation; must not be combined with nitrosating substances and nitrosamine content must be < 50 ppb. LD50 between 1,000–2,000 mg/kg (oral, rat). At 400 mg/kg/day in 90-day study: cataracts, renal tubular nephrosis, thymic lymphoid depletion. SCCP lowered NOAEL to 25 mg/kg/day due to thymic depletion at 100 mg/kg. The EU classifies 3-Methylamino-4-Nitrophenoxyethanol as "prohibited". Safety rating: MODERATE.
Is 3-Methylamino-4-Nitrophenoxyethanol allowed in the EU?
3-Methylamino-4-Nitrophenoxyethanol EU regulatory status: prohibited. Maximum allowed concentration: 0.15%. This is based on EU Regulation 1223/2009 and its amendments.
What does 3-Methylamino-4-Nitrophenoxyethanol do in cosmetics?
3-Methylamino-4-Nitrophenoxyethanol functions as: Non-oxidative (semi-permanent) hair dye. It is classified as a cosmetic ingredient in our database. CAS number: 59820-63-2 (EINECS 261-940-7).
What is the Margin of Safety for 3-Methylamino-4-Nitrophenoxyethanol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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