NOAEL Studies
Cosmetic Ingredient
3-Methylamino-4-Nitrophenoxyethanol NOAEL Studies
INCI: 3-METHYLAMINO-4-NITROPHENOXYETHANOL
CAS: 59820-63-2 (EINECS 261-940-7)
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR_vision_codex 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR_vision_codex | NOAEL | =100 | mg/kg day | rat | dermal | Subchronic | repeated dose toxicity | {"citation":"3; 4; 25, 100","dose":"cute toxicity study using rats, 3-Methylamino-4-Nitrophenoxyethanol at 1000 mg/kg resulted in hypoactivity, piloerection, dyspnea, and lateral recumbency in an- imals that later died.","effect":"cute toxicity study using rats, 3-Methylamino-4-Nitrophenoxyethanol at 1000 mg/kg resulted in hypoactivity, piloerection, dyspnea, and lateral recumbency in an- imals that later died. The surviving rats exhibited none of these signs. No abnormalities were found at necropsy. Subchronic toxic- ity tests using rats fed 25, 100, or 400 mg/kg day−1 3-Methylamino- 4-Nitrophenoxyethanol for up to 93 days resulted in yellow urine and tails with all three dose levels and yellow fur occurred in the two high-dose groups. The no observed adverse effect level (NOAEL) for 3-Methyl-amino-4-Nitrophenoxyethanol was 100 mg/kg day−1. Two percent 3-Methylamino-4-Nitrophenoxyethanol was a slight ocular irritant but not a dermal irritant using rabbits and it was not a sensitizer using the murine local lymph node Assay. There were no embryotoxic or teratogenic effects observed in doses up to 750 mg/kg day−1 in rats; the NOAEL was defined as 100 mg/kg. 3- Methylamino-4-Nitrophenoxyethanol was not genotoxic in in vitro assays including multiple strains of Salmonela typhimurium and Escherichia coli, Chines...","page":1,"pdf":"PRS451.pdf","row_type":"noael_study","study_id":"PRS451_noael_001"} |
| CIR_vision_codex | NOAEL | =100 | - | Sprague-Dawley rats | oral gavage | 92 or 93 days | NOAEL study | {"page":4,"pdf":"PRS451.pdf","row_type":"noael_study","study_id":"noael_subchronic_oral_cit_1995"} |
| CIR_vision_codex | NOAEL | =100 | mg/kg day | rat | dermal | Subchronic | repeated dose toxicity | {"citation":"3; 4; 25, 100","dose":"cute toxicity study using rats, 3-Methylamino-4-Nitrophenoxyethanol at 1000 mg/kg resulted in hypoactivity, piloerection, dyspnea, and lateral recumbency in an- imals that later died.","effect":"cute toxicity study using rats, 3-Methylamino-4-Nitrophenoxyethanol at 1000 mg/kg resulted in hypoactivity, piloerection, dyspnea, and lateral recumbency in an- imals that later died. The surviving rats exhibited none of these signs. No abnormalities were found at necropsy. Subchronic toxic- ity tests using rats fed 25, 100, or 400 mg/kg day−1 3-Methylamino- 4-Nitrophenoxyethanol for up to 93 days resulted in yellow urine and tails with all three dose levels and yellow fur occurred in the two high-dose groups. The no observed adverse effect level (NOAEL) for 3-Methyl-amino-4-Nitrophenoxyethanol was 100 mg/kg day−1. Two percent 3-Methylamino-4-Nitrophenoxyethanol was a slight ocular irritant but not a dermal irritant using rabbits and it was not a sensitizer using the murine local lymph node Assay. There were no embryotoxic or teratogenic effects observed in doses up to 750 mg/kg day−1 in rats; the NOAEL was defined as 100 mg/kg. 3- Methylamino-4-Nitrophenoxyethanol was not genotoxic in in vitro assays including multiple strains of Salmonela typhimurium and Escherichia coli, Chines...","page":1,"pdf":"PRS451.pdf","row_type":"noael_study","study_id":"PRS451_noael_001"} |
| CIR_vision_codex | NOAEL | =100 | - | Sprague-Dawley rats | oral gavage | 92 or 93 days | NOAEL study | {"page":4,"pdf":"PRS451.pdf","row_type":"noael_study","study_id":"noael_subchronic_oral_cit_1995"} |
| CIR_vision_codex | NOAEL | =100 | mg/kg day | rat | dermal | Subchronic | repeated dose toxicity | {"citation":"3; 4; 25, 100","dose":"cute toxicity study using rats, 3-Methylamino-4-Nitrophenoxyethanol at 1000 mg/kg resulted in hypoactivity, piloerection, dyspnea, and lateral recumbency in an- imals that later died.","effect":"cute toxicity study using rats, 3-Methylamino-4-Nitrophenoxyethanol at 1000 mg/kg resulted in hypoactivity, piloerection, dyspnea, and lateral recumbency in an- imals that later died. The surviving rats exhibited none of these signs. No abnormalities were found at necropsy. Subchronic toxic- ity tests using rats fed 25, 100, or 400 mg/kg day−1 3-Methylamino- 4-Nitrophenoxyethanol for up to 93 days resulted in yellow urine and tails with all three dose levels and yellow fur occurred in the two high-dose groups. The no observed adverse effect level (NOAEL) for 3-Methyl-amino-4-Nitrophenoxyethanol was 100 mg/kg day−1. Two percent 3-Methylamino-4-Nitrophenoxyethanol was a slight ocular irritant but not a dermal irritant using rabbits and it was not a sensitizer using the murine local lymph node Assay. There were no embryotoxic or teratogenic effects observed in doses up to 750 mg/kg day−1 in rats; the NOAEL was defined as 100 mg/kg. 3- Methylamino-4-Nitrophenoxyethanol was not genotoxic in in vitro assays including multiple strains of Salmonela typhimurium and Escherichia coli, Chines...","page":1,"pdf":"PRS451.pdf","row_type":"noael_study","study_id":"PRS451_noael_001"} |
| CIR_vision_codex | NOAEL | =100 | - | Sprague-Dawley rats | oral gavage | 92 or 93 days | NOAEL study | {"page":4,"pdf":"PRS451.pdf","row_type":"noael_study","study_id":"noael_subchronic_oral_cit_1995"} |
| CIR_vision_codex | NOAEL | =100 | mg/kg day | rat | dermal | Subchronic | repeated dose toxicity | {"citation":"3; 4; 25, 100","dose":"cute toxicity study using rats, 3-Methylamino-4-Nitrophenoxyethanol at 1000 mg/kg resulted in hypoactivity, piloerection, dyspnea, and lateral recumbency in an- imals that later died.","effect":"cute toxicity study using rats, 3-Methylamino-4-Nitrophenoxyethanol at 1000 mg/kg resulted in hypoactivity, piloerection, dyspnea, and lateral recumbency in an- imals that later died. The surviving rats exhibited none of these signs. No abnormalities were found at necropsy. Subchronic toxic- ity tests using rats fed 25, 100, or 400 mg/kg day−1 3-Methylamino- 4-Nitrophenoxyethanol for up to 93 days resulted in yellow urine and tails with all three dose levels and yellow fur occurred in the two high-dose groups. The no observed adverse effect level (NOAEL) for 3-Methyl-amino-4-Nitrophenoxyethanol was 100 mg/kg day−1. Two percent 3-Methylamino-4-Nitrophenoxyethanol was a slight ocular irritant but not a dermal irritant using rabbits and it was not a sensitizer using the murine local lymph node Assay. There were no embryotoxic or teratogenic effects observed in doses up to 750 mg/kg day−1 in rats; the NOAEL was defined as 100 mg/kg. 3- Methylamino-4-Nitrophenoxyethanol was not genotoxic in in vitro assays including multiple strains of Salmonela typhimurium and Escherichia coli, Chines...","page":1,"pdf":"PRS451.pdf","row_type":"noael_study","study_id":"PRS451_noael_001"} |
| CIR_vision_codex | NOAEL | =100 | - | Sprague-Dawley rats | oral gavage | 92 or 93 days | NOAEL study | {"page":4,"pdf":"PRS451.pdf","row_type":"noael_study","study_id":"noael_subchronic_oral_cit_1995"} |
UnifiedCodex:CIR:beta.noael_studies 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| UnifiedCodex:CIR:beta.noael_studies | - | 100 | - | Sprague-Dawley rats | oral gavage | 92 or 93 days | - | SOURCE_SUBDIR=PRS451; REPORT_TITLE=Final Report on the Safety Assessment of 3-Methylamino-4-Nitrophenoxyethanol as Used in Hair Dyes; OPINION_NUMBER=PRS451; COMMITTEE=safe as a hair dye ingredient in the practices of use and use concentrations described in this safety assessment; REPORT_DATE=2008; VALUE_TEXT=100 mg/kg day⁻¹; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"59820-63-2","citation":"","dose":"","duration":"92 or 93 days","effect":"","endpoint":"","ingredient":"3-Methylamino-4-Nitrophenoxyethanol","loael_value":"","noael_unit":"","noael_value":"100 mg/kg day⁻¹","page":4,"route":"oral gavage","species":"Sprague-Dawley rats","study_id":"noael_subchronic_oral_cit_1995"} |
| UnifiedCodex:CIR:beta.noael_studies | - | 100 | - | Sprague-Dawley (Crl CD(SD)BR) rats | oral | Days 6 to 15 of pregnancy | - | SOURCE_SUBDIR=PRS451; REPORT_TITLE=Final Report on the Safety Assessment of 3-Methylamino-4-Nitrophenoxyethanol as Used in Hair Dyes; OPINION_NUMBER=PRS451; COMMITTEE=safe as a hair dye ingredient in the practices of use and use concentrations described in this safety assessment; REPORT_DATE=2008; VALUE_TEXT=100 mg/kg (maternal toxicity NOAEL); CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"59820-63-2","citation":"","dose":"","duration":"Days 6 to 15 of pregnancy","effect":"","endpoint":"","ingredient":"3-Methylamino-4-Nitrophenoxyethanol","loael_value":"","noael_unit":"","noael_value":"100 mg/kg (maternal toxicity NOAEL)","page":7,"route":"oral","species":"Sprague-Dawley (Crl CD(SD)BR) rats","study_id":"noael_repro_dev_cit_1990"} |
| UnifiedCodex:CIR:beta.noael_studies | repeated dose toxicity | 100 | mg/kg day | rat | dermal | Subchronic | repeated dose toxicity | SOURCE_SUBDIR=PRS451; REPORT_TITLE=Final Report on the Safety Assessment of 3-Methylamino-4-Nitrophenoxyethanol as Used in Hair Dyes; OPINION_NUMBER=PRS451; COMMITTEE=safe as a hair dye ingredient in the practices of use and use concentrations described in this safety assessment; REPORT_DATE=2008; VALUE_TEXT=100; DOSE=cute toxicity study using rats, 3-Methylamino-4-Nitrophenoxyethanol at 1000 mg/kg resulted in hypoactivity, piloerection, dyspnea, and lateral recumbency in an- imals that later died.; EFFECT=cute toxicity study using rats, 3-Methylamino-4-Nitrophenoxyethanol at 1000 mg/kg resulted in hypoactivity, piloerection, dyspnea, and lateral recumbency in an- imals that later died. The surviving rats exhibited none of these signs. No abnormalities were found at necropsy. Subchronic toxic- ity tests using rats fed 25, 100, or 400 mg/kg day−1 3-Methylamino- 4-Nitrophenoxyethanol for up to 93 days resulted in yellow urine and tails with all three dose levels and yellow fur occurred in the two high-dose groups. The no observed adverse effect level (NOAEL) for 3-Methyl-amino-4-Nitrophenoxyethanol was 100 mg/kg day−1. Two percent 3-Methylamino-4-Nitrophenoxyethanol was a slight ocular irritant but not a dermal irritant using rabbits and it was not a sensitizer using the murine local lymph node Assay. There were no embryotoxic or teratogenic effects observed in doses up to 750 mg/kg day−1 in rats; the NOAEL was defined as 100 mg/kg. 3- Methylamino-4-Nitrophenoxyethanol was not genotoxic in in vitro assays including multiple strains of Salmonela typhimurium and Escherichia coli, Chines...; CITATION=3; 4; 25, 100; CITATION_NUMBERS=[3,4,25,100]; REFERENCE=3; 4; 25, 100; DETAILS_JSON={"cas_number":"59820-63-2","citation":"3; 4; 25, 100","dose":"cute toxicity study using rats, 3-Methylamino-4-Nitrophenoxyethanol at 1000 mg/kg resulted in hypoactivity, piloerection, dyspnea, and lateral recumbency in an- imals that later died.","duration":"Subchronic","effect":"cute toxicity study using rats, 3-Methylamino-4-Nitrophenoxyethanol at 1000 mg/kg resulted in hypoactivity, piloerection, dyspnea, and lateral recumbency in an- imals that later died. The surviving rats exhibited none of these signs. No abnormalities were found at necropsy. Subchronic toxic- ity tests using rats fed 25, 100, or 400 mg/kg day−1 3-Methylamino- 4-Nitrophenoxyethanol for up to 93 days resulted in yellow urine and tails with all three dose levels and yellow fur occurred in the two high-dose groups. The no observed adverse effect level (NOAEL) for 3-Methyl-amino-4-Nitrophenoxyethanol was 100 mg/kg day−1. Two percent 3-Methylamino-4-Nitrophenoxyethanol was a slight ocular irritant but not a dermal irritant using rabbits and it was not a sensitizer using the murine local lymph node Assay. There were no embryotoxic or teratogenic effects observed in doses up to 750 mg/kg day−1 in rats; the NOAEL was defined as 100 mg/kg. 3- Methylamino-4-Nitrophenoxyethanol was not genotoxic in in vitro assays including multiple strains of Salmonela typhimurium and Escherichia coli, Chines...","endpoint":"repeated dose toxicity","ingredient":"3-Methylamino-4-Nitrophenoxyethanol","loael_value":"","noael_unit":"mg/kg day","noael_value":"100","page":1,"route":"dermal","species":"rat","study_id":"PRS451_noael_001"} |