NOAEL Studies Cosmetic Ingredient

3-Nitro-P-Hydroxyethylaminophenol NOAEL Studies

CAS: 65235-31-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 100 mg/kg bw/day rat oral 6-15 Gestation day Developmental SCCP; M.H. Savary. IMEXINE FH: Assessment of possible embryotoxic orteratogenic effects by oral route in rats. CIT, Study N°5842 RSR
NTP ICE skin sensitization 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization EC3 0.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13339; Record_ID=skin_sensitization_invivo_3454; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID00215536; Assay=LLNA; Endpoint=EC3; Response=0.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID00215536
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =15 % - - Chronic NOAEL study p.13
SCCS Opinion NOAEL =100 mg/kg/day rat - developmental developmental toxicity Ref: 11a and 11b 3, p.21
SCCS Opinion NOAEL =100 mg/kg rat oral developmental developmental toxicity p.22
SCCS Opinion NOAEL =200 mg/kg bw/day rat - 90-day NOAEL study p.22
SCCS Opinion NOAEL =1000 mg/kg/day rat oral - NOAEL study p.13
SCCS Opinion NOAEL =1000 mg/kg rat - developmental developmental toxicity p.21
Regulatory source 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 15 % - - Chronic - p.13
Regulatory source - 200 mg/kg bw/day rat - 90-day - p.22
Regulatory source - 1000 mg/kg/day rat oral - - p.13
Regulatory source developmental toxicity 100 mg/kg/day rat - developmental developmental toxicity p.21
Regulatory source developmental toxicity 100 mg/kg/day human - developmental developmental toxicity p.21
Regulatory source developmental toxicity =100 mg/kg rat oral developmental developmental toxicity p.22
Regulatory source developmental toxicity 100 mg/kg/day rabbit dermal developmental developmental toxicity p.23
Regulatory source developmental toxicity 1000 mg/kg rat - developmental developmental toxicity p.21
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier AIP2J155AN UNII - - - chemical -