NOAEL Studies Cosmetic Ingredient

3-(P-Cumenyl)-2-Methylpropionaldehyde NOAEL Studies

INCI: 3-(P-CUMENYL)-2-METHYLPROPIONALDEHYDE

CAS: 6658-48-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_skin_sensitization 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CD54, EC200 71.8 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1914; Record_ID=skin_sensitization_invitro_486; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID4052346; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=71.8; Reported_Response_Unit=ug/mL; Response=71.8; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4052346
NTP_ICE_skin_sensitization CV75 256 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1915; Record_ID=skin_sensitization_invitro_486; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID4052346; Assay=h-CLAT; Endpoint=CV75; Reported_Response=256; Reported_Response_Unit=ug/mL; Response=256; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4052346
NTP_ICE_skin_sensitization EC1.5 >2000 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6413; Record_ID=skin_sensitization_invitro_1517; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4052346; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4052346
NTP_ICE_skin_sensitization IC50 86.1 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6417; Record_ID=skin_sensitization_invitro_1517; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4052346; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=86.1; Reported_Response_Unit=uM; Response=86.1; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4052346
NTP_ICE_skin_sensitization Imax 1.03 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6419; Record_ID=skin_sensitization_invitro_1517; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4052346; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.03; Reported_Response_Unit=Unitless; Response=1.03; Response_Unit=Ratio; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4052346
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat dermal short-term; 28 days short-term GUIDELINE=EU Method B.9 (Repeated Dose (28 Days) Toxicity (Dermal)); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d3ae4b096bca8774f69; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25209/7/6/4?documentUUID=b9dac523-6aa0-4c55-b69f-a4153f3bb8dc; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=liver; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID:15826090:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4c1d5be045c0d3f0d6a59e8f0877bc69
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =275 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=EFSA FEEDAP (2017). Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species. doi:10.2903/j.efsa.2017.4672.; TITLE=Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2017.4672; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15620807:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ae15b4234a40d7c16c217d9c1e8160aa
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.529 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630846:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f069d79b000dcef211212f500d99b2ec
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier Z3NXK8Y7EX UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Z3NXK8Y7EX"}
openFDA substances FDA UNII substance identifier Z3NXK8Y7EX UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Z3NXK8Y7EX"}
openFDA substances FDA UNII substance identifier Z3NXK8Y7EX UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Z3NXK8Y7EX"}
openFDA substances FDA UNII substance identifier Z3NXK8Y7EX UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Z3NXK8Y7EX"}