NOAEL Studies Cosmetic Ingredient

4,4'-ISOPROPYLIDENEDIPHENOL NOAEL Studies

CAS: 80-05-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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California Proposition 65 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 MADL SQEdermal=3 ug/day - - 2015-05-11 Maximum allowable dose level {"cancer_reproductive":"female","listed_date":"2015-05-11","listing_mechanism":"SQE","madl":"dermal=3","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 MADL SQEdermal=3 ug/day - - 2015-05-11 Maximum allowable dose level {"cancer_reproductive":"female","listed_date":"2015-05-11","listing_mechanism":"SQE","madl":"dermal=3","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 MADL SQEdermal=3 ug/day - - 2015-05-11 Maximum allowable dose level {"cancer_reproductive":"female","listed_date":"2015-05-11","listing_mechanism":"SQE","madl":"dermal=3","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABdevelopmental listing type - - 2020-12-18 California Proposition 65 listing {"cancer_reproductive":"developmental","listed_date":"2020-12-18","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABdevelopmental listing type - - 2020-12-18 California Proposition 65 listing {"cancer_reproductive":"developmental","listed_date":"2020-12-18","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABdevelopmental listing type - - 2020-12-18 California Proposition 65 listing {"cancer_reproductive":"developmental","listed_date":"2020-12-18","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEfemale listing type - - 2015-05-11 California Proposition 65 listing {"cancer_reproductive":"female","listed_date":"2015-05-11","listing_mechanism":"SQE","madl":"dermal=3","nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEfemale listing type - - 2015-05-11 California Proposition 65 listing {"cancer_reproductive":"female","listed_date":"2015-05-11","listing_mechanism":"SQE","madl":"dermal=3","nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEfemale listing type - - 2015-05-11 California Proposition 65 listing {"cancer_reproductive":"female","listed_date":"2015-05-11","listing_mechanism":"SQE","madl":"dermal=3","nsrl":null,"source_table":"prop65_listings"}
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =5 mg/kg bw/day Mouse - - reproduction toxicity EFSA AFC - 2007 - OutputID 338 - organ weights - reproductive - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to 2,2-BIS(4-HYDROXYPHENYL)PROPANE (Bisphenol A) - doi:10.2903/j.efsa.2007.428
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =5 mg/kg bw/day Mouse - - reproduction toxicity EFSA AFC - 2007 - OutputID 338 - organ weights - reproductive - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to 2,2-BIS(4-HYDROXYPHENYL)PROPANE (Bisphenol A) - doi:10.2903/j.efsa.2007.428
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EPA_IRIS_iris_rfd_systems.csv LOAEL =50 mg/kg/day - oral chronic IRIS chronic oral RfD system PoD row_hash=f0b5950887b7eab4; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=LOAEL : 5.0e1 mg/kg-day; system=Other; basis=Reduced mean body weight; point_of_departure=LOAEL : 5.0e1 mg/kg-day; composite_uf=1000; confidence=High; dtxsid=DTXSID7020182; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=356; rfd_last_updated=09/26/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0356_summary.pdf
EPA_IRIS_iris_rfd_systems.csv RfD =0.05 mg/kg/day - oral chronic IRIS chronic oral RfD system row_hash=46d38f8758101a3d; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=5e-2; system=Other; basis=Reduced mean body weight; point_of_departure=LOAEL : 5.0e1 mg/kg-day; composite_uf=1000; confidence=High; dtxsid=DTXSID7020182; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=356; rfd_last_updated=09/26/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0356_summary.pdf
NTP_ICE_adme_parameters 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 2.326 uL/min/10^6 cells Rat - - Measured; httk, Rat Hepatic Intrinsic Clearance sheet=Data; excel_row=2686; Record_ID=adme_parameters_1; Data_Type=Measured; DTXSID=DTXSID7020182; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=2.326; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Wetmore 2013; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_adme_parameters Clint 19.9 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2688; Record_ID=adme_parameters_1; Data_Type=Measured; DTXSID=DTXSID7020182; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=19.9; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_adme_parameters Fu 0.0385 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2689; Record_ID=adme_parameters_1; Data_Type=Measured; DTXSID=DTXSID7020182; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0385; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_adme_parameters Fu 0.7181 fraction Rat - - Measured; httk, Rat Plasma Fraction Unbound sheet=Data; excel_row=2687; Record_ID=adme_parameters_1; Data_Type=Measured; DTXSID=DTXSID7020182; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.7181; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Wetmore 2013; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_cancer 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer Top dose 2000 ppm Rat Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=7374; Record_ID=cancer_4225; Data_Type=In Vivo; Formulation_Name=Bisphenol A; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Reference=TR-215; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr215/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_cancer Top dose 5000 ppm Mouse Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=7381; Record_ID=cancer_4222; Data_Type=In Vivo; Formulation_Name=Bisphenol A; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=5000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed feed; Reference=TR-215; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr215/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_cancer Top dose 10000 ppm Mouse Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=7372; Record_ID=cancer_4224; Data_Type=In Vivo; Formulation_Name=Bisphenol A; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=10000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Dosed feed; Reference=TR-215; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr215/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine 104 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 0.669617515126504 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=5646; RecordID=ERPathway2016_161; DatasetName=ERPathway2016; DTXSID=DTXSID7020182; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=0.669617515126504; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50 16.8348356403529 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=5640; RecordID=ARPathway2016_286; DatasetName=ARPathway2016; DTXSID=DTXSID7020182; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=16.8348356403529; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 0.1585 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13115; Record_ID=endocrine_invitro_2690; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.15848931899999999; Reported_Response_Unit=nM; Response=0.1585; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 80 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13318; Record_ID=endocrine_invitro_1469; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=80; Reported_Response_Unit=nM; Response=80; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lee et al. 2003; 12805653; 10.1093/toxsci/kfg150; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 158.489 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13257; Record_ID=endocrine_invitro_2761; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=158.489; Reported_Response_Unit=nM; Response=158.489; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 318 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13317; Record_ID=endocrine_invitro_1471; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=318; Reported_Response_Unit=nM; Response=318; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lee et al. 2003; 12805653; 10.1093/toxsci/kfg150; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 746 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13253; Record_ID=endocrine_invitro_1732; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=746; Reported_Response_Unit=nM; Response=746; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Xu et al. 2005; 16169144; 10.1016/j.tox.2005.08.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 920 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13509; Record_ID=endocrine_invitro_2651; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=920; Reported_Response_Unit=nM; Response=920; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Molina-Molina et al. 2013; 23714657; 10.1016/j.taap.2013.05.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 1800 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13277; Record_ID=endocrine_invitro_1461; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=1.8; Reported_Response_Unit=uM; Conversion_Factor=1000; Conversion_Factor_Value=1000; Converted_Response=1800; Converted_Response_Unit=nM; Response=1800; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lee et al. 2003; 12805653; 10.1093/toxsci/kfg150; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 2340 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13240; Record_ID=endocrine_invitro_2599; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=2340; Reported_Response_Unit=nM; Response=2340; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Teng et al. 2013; 23562765; 10.1016/j.cbi.2013.03.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 2500 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13238; Record_ID=endocrine_invitro_2829; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=2500; Reported_Response_Unit=nM; Response=2500; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 2800 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13248; Record_ID=endocrine_invitro_1494; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=2800; Reported_Response_Unit=nM; Response=2800; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Willemsen et al. 2004; 14513195; 10.1007/s00216-003-2217-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 3200 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13242; Record_ID=endocrine_invitro_2002; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=3200; Reported_Response_Unit=nM; Response=3200; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Krüger et al. 2008; 18294747; 10.1016/j.tox.2007.12.028; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 4200 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13281; Record_ID=endocrine_invitro_2253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=4200; Reported_Response_Unit=nM; Response=4200; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 4300 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13519; Record_ID=endocrine_invitro_1669; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=4300; Reported_Response_Unit=nM; Response=4300; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kitamura et al. 2005; 15635150; 10.1093/toxsci/kfi074; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 5000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13517; Record_ID=endocrine_invitro_1685; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=5000; Reported_Response_Unit=nM; Response=5000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Michelini et al. 2005; 15797324; 10.1016/j.bios.2004.10.018; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 5250 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13511; Record_ID=endocrine_invitro_1885; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=5250; Reported_Response_Unit=nM; Response=5250; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Tamura et al. 2006; 16876421; 10.1016/j.bmc.2006.06.064; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 5700 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13493; Record_ID=endocrine_invitro_1889; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=5700; Reported_Response_Unit=nM; Response=5700; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Tamura et al. 2006; 16876421; 10.1016/j.bmc.2006.06.064; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 7000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13515; Record_ID=endocrine_invitro_3097; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=7000; Reported_Response_Unit=nM; Response=7000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Paris et al. 2002; 12161000; 10.1016/s0303-7207(02)00094-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 7900 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=165; Record_ID=endocrine_invitro_159; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=7900; Reported_Response_Unit=nM; Response=7900; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 11800 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13244; Record_ID=endocrine_invitro_2535; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=11800; Reported_Response_Unit=nM; Response=11800; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Rostkowski et al. 2011; 22047186; 10.1021/es202966c; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 19600 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13520; Record_ID=endocrine_invitro_1571; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=19600; Reported_Response_Unit=nM; Response=19600; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 39000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13513; Record_ID=endocrine_invitro_2936; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=39000; Reported_Response_Unit=nM; Response=39000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Roelofs et al. 2015; 25576683; 10.1016/j.tox.2015.01.003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 55380 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8329; Record_ID=endocrine_invitro_2650; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=55380; Reported_Response_Unit=nM; Response=55380; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Molina-Molina et al. 2013; 23714657; 10.1016/j.taap.2013.05.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 62700 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=517; Record_ID=endocrine_invitro_511; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=62700; Reported_Response_Unit=nM; Response=62700; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Oehlmann et al. 2006; 16818258; 10.1289/ehp.8065; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 75000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=169; Record_ID=endocrine_invitro_163; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=75000; Reported_Response_Unit=nM; Response=75000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 110000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=167; Record_ID=endocrine_invitro_161; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=110000; Reported_Response_Unit=nM; Response=110000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kim et al. 2010; 20371976; 10.2131/jts.35.239; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine AC50/EC50/IC50 1000001453 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13104; Record_ID=endocrine_invitro_2593; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=1000001453; Reported_Response_Unit=nM; Response=1000001453; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine ACC 0.228354371372336 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=5647; RecordID=ERPathway2016_161; DatasetName=ERPathway2016; DTXSID=DTXSID7020182; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=0.228354371372336; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine ACC 17.0951719331564 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=5641; RecordID=ARPathway2016_286; DatasetName=ARPathway2016; DTXSID=DTXSID7020182; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=17.0951719331564; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine EC50 533 nM - - - In Vitro; ER Transactivation-Agonist (VM7Luc Assay) sheet=Data_invitro; excel_row=16595; Record_ID=endocrine_invitro_4468; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=ER Transactivation-Agonist (VM7Luc Assay); Endpoint=EC50; Reported_Response=5.3300000000000002E-7; Reported_Response_Unit=M; Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=533; Converted_Response_Unit=nM; Response=533; Response_Unit=nM; Reference=|OECD TG 455; https://www.oecd.org/env/test-no-455-performance-based-test-guideline-for-stably-transfected-transactivation-in-vitro-assays-to-detect-estrogen-receptor-9789264265295-en.htm; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine IC01 408 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13015; Record_ID=endocrine_invitro_2679; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=IC01; Reported_Response=408; Reported_Response_Unit=IC01 (nM); Response=408; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine IC20 <10000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13026; Record_ID=endocrine_invitro_2900; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=IC20; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=10000; Reported_Response_Unit=IC20 (nM); Response=10000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine IC25 <1000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13067; Record_ID=endocrine_invitro_2029; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=IC25; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=1000; Reported_Response_Unit=IC25 (nM); Response=1000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bonefeld-Jørgensen et al. 2007; 18174953; 10.1289/ehp.9368; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine IC50 1500 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13279; Record_ID=endocrine_invitro_2958; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=IC50; Reported_Response=1.5E-6; Reported_Response_Unit=IC50 (M); Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=1500; Converted_Response_Unit=nM; Response=1500; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lee et al. 2003; 12805653; 10.1093/toxsci/kfg150; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine IC50 3350 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13390; Record_ID=endocrine_invitro_2735; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=IC50; Reported_Response=3.35; Reported_Response_Unit=IC50 (uM); Conversion_Factor=1000; Conversion_Factor_Value=1000; Converted_Response=3350; Converted_Response_Unit=nM; Response=3350; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fic et al. 2014; 25048928; 10.1016/j.chemosphere.2014.04.080; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine IC50 81000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13392; Record_ID=endocrine_invitro_2964; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=IC50; Reported_Response=8.1000000000000004E-5; Reported_Response_Unit=IC50 (M); Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=81000; Converted_Response_Unit=nM; Response=81000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Ki 18000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1865; Record_ID=endocrine_invitro_1098; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=Ki; Reported_Response=18000; Reported_Response_Unit=nM; Response=18000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lee et al. 2003; 12805653; 10.1093/toxsci/kfg150; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LEL 0.1 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14955; Record_ID=endocrine_invitro_1573; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=0.1; Reported_Response_Unit=nM; Response=0.1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Stroheker et al. 2004; 15110097; 10.1016/j.fct.2004.01.012; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LEL 1 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10778; Record_ID=endocrine_invitro_2917; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=1; Reported_Response_Unit=nM; Response=1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LEL 10 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=15118; Record_ID=endocrine_invitro_2347; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=10; Reported_Response_Unit=nM; Response=10; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Christen et al. 2010; 20943248; 10.1016/j.chemosphere.2010.09.031; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LEL 100 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14953; Record_ID=endocrine_invitro_1732; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=100; Reported_Response_Unit=nM; Response=100; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Xu et al. 2005; 16169144; 10.1016/j.tox.2005.08.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LEL 199.5 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14957; Record_ID=endocrine_invitro_2651; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=199.52600000000001; Reported_Response_Unit=nM; Response=199.5; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Molina-Molina et al. 2013; 23714657; 10.1016/j.taap.2013.05.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LEL 600 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14961; Record_ID=endocrine_invitro_1988; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=600; Reported_Response_Unit=nM; Response=600; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bonefeld-Jørgensen et al. 2007; 18174953; 10.1289/ehp.9368; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LEL 1584.89 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14949; Record_ID=endocrine_invitro_1273; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=1584.89; Reported_Response_Unit=nM; Response=1584.89; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LEL 2000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14963; Record_ID=endocrine_invitro_2250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=2000; Reported_Response_Unit=nM; Response=2000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ermler et al. 2010; 20488240; 10.1016/j.tiv.2010.05.007; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LEL 3000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14951; Record_ID=endocrine_invitro_3097; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=3000; Reported_Response_Unit=nM; Response=3000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Paris et al. 2002; 12161000; 10.1016/s0303-7207(02)00094-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LEL 4380 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14970; Record_ID=endocrine_invitro_2583; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=1000000; Reported_Response_Unit=ng/L; Conversion_Factor=Molecular Weight; Conversion_Factor_Value=228.291; Conversion_Factor_Source=EPA Dashboard; Converted_Response=4380.3741715617352; Converted_Response_Unit=nM; Response=4380; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LEL 10000 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10556; Record_ID=endocrine_invitro_2650; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=10000; Reported_Response_Unit=nM; Response=10000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Molina-Molina et al. 2013; 23714657; 10.1016/j.taap.2013.05.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 2 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1014; Record_ID=endocrine_invivo_361; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=2; Response_Unit=mg/kg/day; Species=Rat; Sex=Female; Route=Subcutaneous; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Takeyoshi 2006; Not available; https://www.oecd.org/env/ehs/testing/37504278.pdf|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 10 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1016; Record_ID=endocrine_invivo_456; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=10; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Hsd:SD; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 20 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 20 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1011; Record_ID=endocrine_invivo_358; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=20; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crj:CD(SD); Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Yamasaki et al. 2002; 11750080; 10.1016/s0300-483x(01)00505-4|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 30 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1022; Record_ID=endocrine_invivo_375; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=30; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=300; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 3; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 50 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 84; Age_Ovariectomized_or_Castrated=8 Weeks; Time_Elapsed_Between_Surgery_and_Treatment=4 weeks; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=988; Record_ID=endocrine_invivo_455; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=50; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Jcl:Sprague-Dawley; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=100; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Takemura et al. 2005; 15596252; 10.1016/j.tox.2004.09.015|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 75 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1018; Record_ID=endocrine_invivo_369; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=75; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=75; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 6; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 100 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=999; Record_ID=endocrine_invivo_349; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=600; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 200 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1013; Record_ID=endocrine_invivo_360; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=200; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=SD; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Ohno et al. 2003; 12453737; 10.1016/s0278-6915(02)00211-9|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 300 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1004; Record_ID=endocrine_invivo_342; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=300; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Wistar (Hsd/Cpb:WU); Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 375 mg/kg bw/day Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1009; Record_ID=endocrine_invivo_356; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=375; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=600; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 400 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 to 3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1015; Record_ID=endocrine_invivo_364; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=400; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=600; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Diethylstilbestrol; Reference=Ashby and Tonwell 1998; 9799186; 10.1289/ehp.98106719|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 600 mg/kg bw/day Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1010; Record_ID=endocrine_invivo_357; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=600; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 800 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 21 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=7 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1005; Record_ID=endocrine_invivo_354; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=800; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Alpk:APfSD; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Matthews et al. 2001; 11258963; 10.1021/tx0001833|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine LOEL 1000 mg/kg bw/day Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1019; Record_ID=endocrine_invivo_368; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=1000; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=SPF-bred Wistar, HSD/Cpb:WU; Strain=Wistar; Sex=Female; Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=5643; RecordID=ARPathway2016_286; DatasetName=ARPathway2016; DTXSID=DTXSID7020182; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Model Score 0.345 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=5642; RecordID=ARPathway2016_286; DatasetName=ARPathway2016; DTXSID=DTXSID7020182; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.345; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Model Score 0.45 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=5648; RecordID=ERPathway2016_161; DatasetName=ERPathway2016; DTXSID=DTXSID7020182; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.45; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine NOEL 600 mg/kg bw/day Rat Oral Treatment_Duration=10 days; Age_at_First_Dose=PND 56; Age_Ovariectomized_or_Castrated=PND 42; Time_Elapsed_Between_Surgery_and_Treatment=14 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 36 hours; Number_of_Doses_Tested=6 In Vivo; Hershberger-Agonist sheet=Data_invivo; excel_row=2189; Record_ID=endocrine_invivo_941; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Hershberger-Agonist; Endpoint=NOEL; Response=600; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Sprague-Dawley; Strain=Sprague-Dawley; Sex=Male (castrated); Route=Oral; Reference_Hormone=Testosterone propionate; Reference_Hormone_Dose=0.2; Reference_Hormone_Dose_Units=mg/kg/day; Reference_Hormone_Route=Subcutaneous; Additional_Information=Browne et al. 2018 unique record identifier 264; Reference=Yamasaki et al. 2003; 12504345; 10.1016/s0300-483x(02)00445-6|Browne et al. 2018; 30205136; 10.1016/j.reprotox.2018.08.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine PC50 294 nM - - - In Vitro; ER Transactivation-Agonist (STTA Assay) sheet=Data_invitro; excel_row=16542; Record_ID=endocrine_invitro_4468; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=ER Transactivation-Agonist (STTA Assay); Endpoint=PC50; Reported_Response=2.9400000000000001E-7; Reported_Response_Unit=M; Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=294; Converted_Response_Unit=nM; Response=294; Response_Unit=nM; Reference=|OECD TG 455; https://www.oecd.org/env/test-no-455-performance-based-test-guideline-for-stably-transfected-transactivation-in-vitro-assays-to-detect-estrogen-receptor-9789264265295-en.htm; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine RBA 0.004074 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1967; Record_ID=endocrine_invitro_163; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=RBA; Reported_Response=-2.39; Reported_Response_Unit=Unitless; Conversion_Factor=Anti-log; Converted_Response=4.0738027780411225E-3; Converted_Response_Unit=Unitless; Response=0.004074; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine RBA 0.0041 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2443; Record_ID=endocrine_invitro_163; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=RBA; Reported_Response=4.1000000000000003E-3; Reported_Response_Unit=Unitless; Response=0.0041; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine RBA 0.016 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2445; Record_ID=endocrine_invitro_161; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=RBA; Reported_Response=1.6E-2; Reported_Response_Unit=Unitless; Response=1.6E-2; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kim et al. 2010; 20371976; 10.2131/jts.35.239; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine RBA 0.0301 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2442; Record_ID=endocrine_invitro_1102; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=RBA; Reported_Response=3.0099999999999998E-2; Reported_Response_Unit=Unitless; Response=0.0301; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Liu et al. 2009; 19862954; 10.1016/s1001-0742(08)62356-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine RBA 0.215 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2444; Record_ID=endocrine_invitro_164; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.215; Reported_Response_Unit=Unitless; Response=0.215; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine RIC20 1200 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13348; Record_ID=endocrine_invitro_3069; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=RIC20; Reported_Response=1200; Reported_Response_Unit=RIC20 (nM); Response=1200; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Relative potency 45 % - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=15206; Record_ID=endocrine_invitro_2741; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=Relative potency; Reported_Response=45; Reported_Response_Unit=%; Response=45; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ermler et al. 2010; 20488240; 10.1016/j.tiv.2010.05.007; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 120 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=709; Record_ID=endocrine_invivo_361; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=120; Response_Unit=%; Species=Rat; Sex=Female; Route=Subcutaneous; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Takeyoshi 2006; Not available; https://www.oecd.org/env/ehs/testing/37504278.pdf|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 124.1 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 21 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=8 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=711; Record_ID=endocrine_invivo_345; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=124.1; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:APfSD; Strain=Alderley Park; Sex=Female; Route=Oral; Maximum_Dose=800.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 126 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=706; Record_ID=endocrine_invivo_341; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=126; Response_Unit=%; Species=Rat; Reported_Strain=SPF/VAF Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 128 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=708; Record_ID=endocrine_invivo_344; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=128; Response_Unit=%; Species=Rat; Reported_Strain=SD; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 130 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=720; Record_ID=endocrine_invivo_382; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=130; Response_Unit=%; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=75; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 4; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 131 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=690; Record_ID=endocrine_invivo_357; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=131; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 131.4 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 to 3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=721; Record_ID=endocrine_invivo_348; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=131.4; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female; Route=Oral; Maximum_Dose=600.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Diethylstilbestrol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 136 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=703; Record_ID=endocrine_invivo_356; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=136; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=600; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 137 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=687; Record_ID=endocrine_invivo_342; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=137; Response_Unit=%; Species=Rat; Reported_Strain=Wistar (Hsd/Cpb:WU); Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 140 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=4 or 24 hours; Number_of_Doses_Tested=8 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=714; Record_ID=endocrine_invivo_346; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=140; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:APfSD (Wistar derived); Strain=Alderley Park; Sex=Female; Route=Oral; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Ashby and Odum 2004; 15456929; 10.1093/toxsci/kfh283|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 141 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 20 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=705; Record_ID=endocrine_invivo_358; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=141; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD); Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Yamasaki et al. 2002; 11750080; 10.1016/s0300-483x(01)00505-4|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 143 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=702; Record_ID=endocrine_invivo_377; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=143; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)BR; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 147 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=701; Record_ID=endocrine_invivo_355; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=147; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:ApfSD; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 149.5 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 to 3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=691; Record_ID=endocrine_invivo_364; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=149.5; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=600.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Diethylstilbestrol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 150 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=704; Record_ID=endocrine_invivo_378; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=150; Response_Unit=%; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=75; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 5; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 157 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=693; Record_ID=endocrine_invivo_368; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=157; Response_Unit=%; Species=Rat; Reported_Strain=SPF-bred Wistar, HSD/Cpb:WU; Strain=Wistar; Sex=Female; Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 160 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=695; Record_ID=endocrine_invivo_370; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=160; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:ApfSD; Strain=Alderley Park; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 167 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=727; Record_ID=endocrine_invivo_350; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=167; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 172 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=688; Record_ID=endocrine_invivo_353; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=172; Response_Unit=%; Species=Rat; Reported_Strain=SPF-bred Wistar, HSD/Cpb:WU; Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 175 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1008; Record_ID=endocrine_invivo_456; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=175; Response_Unit=%; Species=Rat; Reported_Strain=Hsd:SD; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 189 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=692; Record_ID=endocrine_invivo_366; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=189; Response_Unit=%; Species=Rat; Reported_Strain=SPF/VAF Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 190 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=718; Record_ID=endocrine_invivo_379; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=190; Response_Unit=%; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=600; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 1; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 203 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=724; Record_ID=endocrine_invivo_349; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=203; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=600.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 205 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=699; Record_ID=endocrine_invivo_373; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=205; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=600.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 216.7 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 21 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=7 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=737; Record_ID=endocrine_invivo_354; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=216.7; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:APfSD; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=800.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 230 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=707; Record_ID=endocrine_invivo_360; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=230; Response_Unit=%; Species=Rat; Reported_Strain=SD; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Ohno et al. 2003; 12453737; 10.1016/s0278-6915(02)00211-9|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 235 % Rat Subcutaneous Treatment_Duration=7 days; Age_at_First_Dose=PND 56 to 86; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=719; Record_ID=endocrine_invivo_380; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=235; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol D; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 251 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=700; Record_ID=endocrine_invivo_374; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=251; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=600.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP_ICE_endocrine Uterine weight increase vs control 253 % Rat Subcutaneous Treatment_Duration=7 days; Age_at_First_Dose=PND 56 to 85; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=697; Record_ID=endocrine_invivo_371; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=253; Response_Unit=%; Species=Rat; Reported_Strain=SPF/VAF Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=800.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol D; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
SCCS_vision_codex 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS_vision_codex NOAEL =1 - rat - developmental reproductive toxicity {"dose":"In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose.","effect":"ot a skin irritant, but it can lead to serious eye damage (Eye Dam. 1), is able to elicit skin sensitization (Skin Sens. 1) and may cause respiratory irritation (STOT SE 3) (ECHA 2017). BPA has low acute toxicity for all routes of exposure relevant to human health (EFSA 2015). BPA has been found to affect kidney and liver weight in parental animals and in all the generations of rats and mice examined in multi-generation studies. EFSA considered these effects as relevant systemic effects for the identification of a NOAEL in their risk assessment. In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose. Liver weight was increased in rats (relative weight) and mice (both absolute and relative weight). The latter species also showed hepatocellular hypertrophy (EFSA 2015). Reproductive and developmental effects BPA is classified as toxic for reproduction (Repr. 1B) (ECHA 2017). Exposure to BPA at the adult stage alters the endocrine steroidogenic function of the ovary and more specifically the pro","page":28,"pdf":"sccs_o_240.pdf","row_type":"noael_study","study_id":"sccs_o_240_noael_001"}
SCCS_vision_codex NOAEL =1 - rat - developmental reproductive toxicity {"dose":"In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose.","effect":"ot a skin irritant, but it can lead to serious eye damage (Eye Dam. 1), is able to elicit skin sensitization (Skin Sens. 1) and may cause respiratory irritation (STOT SE 3) (ECHA 2017). BPA has low acute toxicity for all routes of exposure relevant to human health (EFSA 2015). BPA has been found to affect kidney and liver weight in parental animals and in all the generations of rats and mice examined in multi-generation studies. EFSA considered these effects as relevant systemic effects for the identification of a NOAEL in their risk assessment. In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose. Liver weight was increased in rats (relative weight) and mice (both absolute and relative weight). The latter species also showed hepatocellular hypertrophy (EFSA 2015). Reproductive and developmental effects BPA is classified as toxic for reproduction (Repr. 1B) (ECHA 2017). Exposure to BPA at the adult stage alters the endocrine steroidogenic function of the ovary and more specifically the pro","page":28,"pdf":"sccs_o_240.pdf","row_type":"noael_study","study_id":"sccs_o_240_noael_001"}
SCCS_vision_codex NOAEL =1 - rat - developmental reproductive toxicity {"dose":"In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose.","effect":"ot a skin irritant, but it can lead to serious eye damage (Eye Dam. 1), is able to elicit skin sensitization (Skin Sens. 1) and may cause respiratory irritation (STOT SE 3) (ECHA 2017). BPA has low acute toxicity for all routes of exposure relevant to human health (EFSA 2015). BPA has been found to affect kidney and liver weight in parental animals and in all the generations of rats and mice examined in multi-generation studies. EFSA considered these effects as relevant systemic effects for the identification of a NOAEL in their risk assessment. In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose. Liver weight was increased in rats (relative weight) and mice (both absolute and relative weight). The latter species also showed hepatocellular hypertrophy (EFSA 2015). Reproductive and developmental effects BPA is classified as toxic for reproduction (Repr. 1B) (ECHA 2017). Exposure to BPA at the adult stage alters the endocrine steroidogenic function of the ovary and more specifically the pro","page":28,"pdf":"sccs_o_240.pdf","row_type":"noael_study","study_id":"sccs_o_240_noael_001"}
SCCS_vision_codex NOAEL =1 - rat - developmental reproductive toxicity {"dose":"In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose.","effect":"ot a skin irritant, but it can lead to serious eye damage (Eye Dam. 1), is able to elicit skin sensitization (Skin Sens. 1) and may cause respiratory irritation (STOT SE 3) (ECHA 2017). BPA has low acute toxicity for all routes of exposure relevant to human health (EFSA 2015). BPA has been found to affect kidney and liver weight in parental animals and in all the generations of rats and mice examined in multi-generation studies. EFSA considered these effects as relevant systemic effects for the identification of a NOAEL in their risk assessment. In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose. Liver weight was increased in rats (relative weight) and mice (both absolute and relative weight). The latter species also showed hepatocellular hypertrophy (EFSA 2015). Reproductive and developmental effects BPA is classified as toxic for reproduction (Repr. 1B) (ECHA 2017). Exposure to BPA at the adult stage alters the endocrine steroidogenic function of the ovary and more specifically the pro","page":28,"pdf":"sccs_o_240.pdf","row_type":"noael_study","study_id":"sccs_o_240_noael_001"}
ToxRefDB_ToxRefDB_v3_pod.csv 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxRefDB_ToxRefDB_v3_pod.csv LEL =160 mg/kg bw/day rat oral 6 GD to 15 GD DEV study_id=2612; toxval_study_source_id=studyid2612_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-lethargy|in life observation-clinical signs-pica|in life observation-body weight-body weight gain|in life observation-body weight-body weight|in life observation-clinical signs-piloerection|in life observation-clinical signs-fur (altered appearance); dose_level=1; study_year=1985; study_citation=NTP (1985) Teratologic evaluation of bisphenol A administered to CD rats on gestation days 6 through 15. NTP-85-089; dsstox_substance_id=DTXSID7020182; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL >1280 mg/kg bw/day rat oral 6 GD to 15 GD DEV study_id=2612; toxval_study_source_id=studyid2612_Fetal_Fetal_MF_NA; dose_level=4; study_year=1985; study_citation=NTP (1985) Teratologic evaluation of bisphenol A administered to CD rats on gestation days 6 through 15. NTP-85-089; dsstox_substance_id=DTXSID7020182; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL >0 mg/kg bw/day rat oral 6 GD to 15 GD DEV study_id=2612; toxval_study_source_id=studyid2612_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-fur (altered appearance)|in life observation-clinical signs-lethargy|in life observation-body weight-body weight|in life observation-body weight-body weight gain|in life observation-clinical signs-pica|in life observation-clinical signs-piloerection; dose_level=0; study_year=1985; study_citation=NTP (1985) Teratologic evaluation of bisphenol A administered to CD rats on gestation days 6 through 15. NTP-85-089; dsstox_substance_id=DTXSID7020182; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =50 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba1a2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/15752?documentUUID=da4fb77b-5b73-45c1-b64b-4bf313fcd139; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=P0: mortality|P0: clinical biochemistry|P0: organ weights and organ / body weight ratios|P0: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15855714:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_10a19969dded60327d5a3bd4af491b30
ToxValDB_ECHA_IUCLID NOAEL =150 mg/kg bw/day Rat oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac7ae4b0a7c65d1bf424; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/15752?documentUUID=da4fb77b-5b73-45c1-b64b-4bf313fcd139; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15820640:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8250748fb280e8d354d8dfac89482fc6
ToxValDB_ECOTOX 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =125 mg/kg bw/day Rat injection short-term; 21 days developmental LONG_REF=Scand. J. Work Environ. Health7(Suppl. 4): 66-75 Hardin,B.D., G.P. Bond, M.R. Sikov, F.D. Andrew, R.P. Beliles, and R.W. Niemeier Testing of Selected Workplace Chemicals for Teratogenic Potential 1981; TITLE=Testing of Selected Workplace Chemicals for Teratogenic Potential; AUTHOR=Hardin,B.D., G.P. Bond, M.R. Sikov, F.D. Andrew, R.P. Beliles, and R.W. Niemeier; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=49968; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Development: Abnormal|Development: Slowed, Retarded, Delayed or Non-development|Multiple: Multiple effects reported as one result|Reproduction: Number of implantations|Reproduction: Pregnant, Paris or Gravid; TOXICOLOGICAL_EFFECT_CATEGORY=development|multiple|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594947_15594948_15594949_15599008:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d6d7989cd273b74361a08e4d1c503d07
ToxValDB_ECOTOX LOEL =200 mg/kg bw/day Rat oral short-term; 14 days short-term LONG_REF=Reprod. Toxicol.33(3): 339-352 Quignot,N., M. Arnaud, F. Robidel, A. Lecomte, M. Tournier, C. Cren-Olive, R. Barouki, and E. Lemazurier Characterization of Endocrine-Disrupting Chemicals Based on Hormonal Balance Disruption in Male and Female Adult Rats 2012; TITLE=Characterization of Endocrine-Disrupting Chemicals Based on Hormonal Balance Disruption in Male and Female Adult Rats; AUTHOR=Quignot,N., M. Arnaud, F. Robidel, A. Lecomte, M. Tournier, C. Cren-Olive, R. Barouki, and E. Lemazurier; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=165355; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight|Reproduction: Velocity; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|reproduction; STUDY_GROUP=ECOTOX:15611650:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=4a332d01caf928acb3a7e575deede9db
ToxValDB_ECOTOX NOEL =0.1 mg Rat injection short-term; 13 days reproduction developmental LONG_REF=Endocrinology143(12): 4797-4808 Rivas,A., J.S. Fisher, C. McKinnell, N. Atanassova, and R.M. Sharpe Induction of Reproductive Tract Developmental Abnormalities in the Male Rat by Lowering Androgen Production or Action in Combination with a Low Dose of Diethylstilbestrol: Evidence for Importance of the Androgen-Estrog 2002; TITLE=Induction of Reproductive Tract Developmental Abnormalities in the Male Rat by Lowering Androgen Production or Action in Combination with a Low Dose of Diethylstilbestrol: Evidence for Importance of the Androgen-Estrog; AUTHOR=Rivas,A., J.S. Fisher, C. McKinnell, N. Atanassova, and R.M. Sharpe; DOI=10.1210/en.2002-220531; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=108224; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Cell(s): Height|Hormone(s): Testosterone|Morphology: Area; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|gross pathology|other; STUDY_GROUP=ECOTOX:15594316:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5af1f0da7c6a8f5e1e58be7ab0fb72da
ToxValDB_ECOTOX NOEL =0.5 mg Rat injection subchronic; 89 days reproduction developmental LONG_REF=Int. J. Androl.26(1): 26-36 Sharpe,R.M., A. Rivas, M. Walker, C. McKinnell, and J.S. Fisher Effect of Neonatal Treatment of Rats with Potent or Weak (Environmental) Oestrogens, or with a GnRH Antagonist, on Leydig Cell Development and Function Through Puberty into Adulthood 2003; TITLE=Effect of Neonatal Treatment of Rats with Potent or Weak (Environmental) Oestrogens, or with a GnRH Antagonist, on Leydig Cell Development and Function Through Puberty into Adulthood; AUTHOR=Sharpe,R.M., A. Rivas, M. Walker, C. McKinnell, and J.S. Fisher; DOI=10.1046/j.1365-2605.2003.00385.x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=108194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Cell(s): Volume|Hormone(s): Testosterone; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595249_15600635:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=79fa2e17343cd549c4855029f03ff8f3
ToxValDB_ECOTOX NOEL =1 % Mouse oral chronic; 294 days chronic LONG_REF=Fundam. Appl. Toxicol.39(1): 1-10 Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays 1997; TITLE=Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays; AUTHOR=Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel; DOI=10.1006/faat.1997.2338; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=151647; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Reproduction: Number of ovarian follicles; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15598021:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=466e5a74dbf51817f9939587fe74fb60
ToxValDB_ECOTOX NOEL =85 mg/kg bw/day Rat injection short-term; 21 days developmental LONG_REF=Scand. J. Work Environ. Health7(Suppl. 4): 66-75 Hardin,B.D., G.P. Bond, M.R. Sikov, F.D. Andrew, R.P. Beliles, and R.W. Niemeier Testing of Selected Workplace Chemicals for Teratogenic Potential 1981; TITLE=Testing of Selected Workplace Chemicals for Teratogenic Potential; AUTHOR=Hardin,B.D., G.P. Bond, M.R. Sikov, F.D. Andrew, R.P. Beliles, and R.W. Niemeier; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=49968; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Development: Abnormal|Development: Slowed, Retarded, Delayed or Non-development|Reproduction: Number of implantations|Reproduction: Pregnant, Paris or Gravid; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594947_15594948_15594949_15599008:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=db8239956e23e08f389c4551da559a42
ToxValDB_EFSA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA BMDL (10) =0.609 mg/kg bw/day Mouse oral - repeat dose other LONG_REF=EFSA CEF (2015). Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary. doi:10.2903/j.efsa.2015.3978.; TITLE=Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2015.3978; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=EFSA:15614270:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_faa0cd36bbbeb75b64401e873b31ded5
ToxValDB_EFSA BMDL (10) =8.96 mg/kg bw/day Mouse oral - reproduction developmental LONG_REF=EFSA CEF (2015). Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary. doi:10.2903/j.efsa.2015.3978.; TITLE=Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2015.3978; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=organ weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=EFSA:15614269:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_804958193ba00feffaf655954dfd96be
ToxValDB_EFSA NOAEL =5 mg/kg bw/day Mouse oral - reproduction developmental LONG_REF=EFSA AFC (2007). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to 2,2-BIS(4-HYDROXYPHENYL)PROPANE (Bisphenol A). doi:10.2903/j.efsa.2007.428.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to 2,2-BIS(4-HYDROXYPHENYL)PROPANE (Bisphenol A); AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2007.428; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=organ weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=EFSA:15614268:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3288eb82f1d45412d6849cdcf7ef41d6
ToxValDB_EPA_TSCA_8e 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EPA_TSCA_8e LEL =1 mg/L Rat oral subchronic (developmental); 9 weeks reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88960000061_80057_73FC987A7C1F773885256E6F0050C7D1.pdf; TOXICOLOGICAL_EFFECT=F1: reduced testicular size; STUDY_GROUP=EPA TSCA 8e:15956970:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c83b6f1a87cdb6c03535947f848099aa
ToxValDB_EPA_TSCA_8e LEL =20 ng/g bw Mouse oral - repeat dose other STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=09022526801189f9_8EHQ-02-15079_11-30-2012_8EF_PHCS_Support - 89120000553.pdf; TOXICOLOGICAL_EFFECT=increased incidence of defects in alignment of chromosomes in oocytes; STUDY_GROUP=EPA TSCA 8e:15956969:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_abe82dfa6c95b2da6cf19592b69c2f6a
ToxValDB_EU_SCOEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EU_SCOEL NOAEC =10 mg/m3 Rat inhalation subchronic; 13 weeks subchronic LONG_REF=Nitschke KD, Lomax LG, Schuetz DJ, Hopkins PJ, Weiss SW (1988). Bisphenol-A: 13 week aerosol toxicity study with Fischer 344 rats. Dow Chemical Company, unpublished report.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985b9e4b02565fc7d35af; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/089_4-4-isopropylidenediphenol_oel_en.pdf; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=mild olfactory epithelium inflammation; STUDY_GROUP=EU SCOEL:15952296:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ab0b91c630fbcdd477b2e262ed05cab7
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =2 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632893_15632894:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5e6e5515b4bdc735cc4b2657a5634f50
ToxValDB_HAWC_Project 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HAWC_Project LOEL =20 mg/kg bw/day Rat injection short-term; 3 days short-term LONG_REF=Yamasaki K, Takeyoshi M, Yakabe Y, Sawaki M, Imatanaka N, Takatsuki M. 2002. Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals. Toxicology 170:21-30.; TITLE=Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals.; AUTHOR=Yamasaki K, Takeyoshi M, Yakabe Y, Sawaki M, Imatanaka N, Takatsuki M; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/46/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/21085/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=uterus: uterine dry weight (absolute); TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=HAWC Project_dup_-_15636115_15636545:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d21af4292c60d8a5e73bc82ff4b76458
ToxValDB_HAWC_Project NOEL =2 mg/kg bw/day Rat injection short-term; 3 days short-term LONG_REF=Yamasaki K, Takeyoshi M, Yakabe Y, Sawaki M, Imatanaka N, Takatsuki M. 2002. Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals. Toxicology 170:21-30.; TITLE=Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals.; AUTHOR=Yamasaki K, Takeyoshi M, Yakabe Y, Sawaki M, Imatanaka N, Takatsuki M; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/46/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/21085/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=uterus: uterine dry weight (absolute); TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=HAWC Project_dup_-_15636115_15636545:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_935aedd5eda0751a982b12a41d707404
ToxValDB_HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HESS NOEL =40 mg/kg bw/day Rat oral - subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0defe4b0a676289de8c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Deaths|Clinical Observation: Loose stool Locomotor activity decrease, Hypopnea Subnormal temperature decrease|Body Weight Changes: decrease|Food Consumption: decrease|Hematology: PT increase, Hgb decrease, Hct decrease|Blood Chemistry: GOT increase, , Che decrease, TG decrease, Alp increase, gamma-GTP increase, Alb decrease|Relative Organ Weight: Heart decrease, Testis increase, prostate gland decrease, adrenal increase, Thyroid increase, liver increase|Histopathology: Duodenum-Lacteal dilatation Cecum-Mucosal hyperplasia Colon-Mucosal hyperplasia Liver-Prominent nucleoli hepatocytes Kidney-Tubular degeneration/necrosis Forestomach-Squamous epithelial cell hyperplasia Jejunum-Lacteal dilatation Adrenal-Cortical vacuolization; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=HESS:15638416:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0b3a7ca898558970c6ef35a74281f9b7
ToxValDB_HPVIS 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS LOAEL =1000 ppm Rat oral chronic; 103 weeks reproduction developmental LONG_REF=Integrated Risk Information System (IRIS Document); Bisphenol A. CASRN: 80-05-7. 1993.Data entered into the HPVIS extracted from the robust summary document posted to the HPV Challenge Program website Mar. 30, 2007.; QUALITY=2; EXTERNAL_SOURCE_ID=63322; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=HPVIS:15639393:-:F0parental; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_afe84fa9a5c8826c67b71631c05fe872
ToxValDB_HPVIS NOAEL =75 ppm Rat oral subchronic; 13 weeks reproduction developmental LONG_REF=R.W. Tyl, Ph.D., DABT, C.B. Myers, M.S, M.C. Marr, B.A., LATG. 2000. Three-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD Sprague-Dawley Rats. RTI Report #: 65C-07036000.Data entered into the HPVIS extracted from the robust summary document posted to the HPV Challenge Program website Mar. 30, 2007.; QUALITY=1; EXTERNAL_SOURCE_ID=65504; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15643256:-:F0parental; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_efc9f4811eb0026b60d3944fcfdab89c
ToxValDB_HPVIS NOAEL >640 mg/kg bw/day Rat oral short-term; 10 days developmental LONG_REF=Morrissey, R.E., George, J.D., Price, C.J., Tyl, R.W., Marr, M.C. and Kimmel, C.A. 1987. The developmental toxicity of bisphenol A in rats and mice. Fundam. Appl. Toxicol. 8:571-582. As cited in the EU Risk Assessment.Data entered into the HPVIS extracted from the robust summary document posted to the HPV Challenge Program website Mar. 30, 2007.; QUALITY=1; EXTERNAL_SOURCE_ID=58035; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15642325:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_29f8d03a0ed491abf3a8caad1f6f8143
ToxValDB_HPVIS NOAEL =750 ppm Rat oral subchronic; 13 weeks reproduction developmental LONG_REF=R.W. Tyl, Ph.D., DABT, C.B. Myers, M.S, M.C. Marr, B.A., LATG. 2000. Three-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD Sprague-Dawley Rats. RTI Report #: 65C-07036000.Data entered into the HPVIS extracted from the robust summary document posted to the HPV Challenge Program website Mar. 30, 2007.; QUALITY=1; EXTERNAL_SOURCE_ID=65503; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15643255:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc6421dcc0ff027b6ccd28539ea01a3b
ToxValDB_IRIS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_IRIS LOAEL =50 mg/kg bw/day Rat oral chronic; 103 weeks chronic LONG_REF=NTP (National Toxicology Program). 1982. NTP Technical report on the carcinogenesis bioassay of bisphenol A (CAS No. 80-05-7) in F344 rats and B6C3F1 mice (feed study). NTP?80-35. NIH Publ. No. 82-1770; TITLE=NTP Technical report on the carcinogenesis bioassay of bisphenol A (CAS No. 80-05-7) in F344 rats and B6C3F1 mice (feed study); AUTHOR=NTP (National Toxicology Program); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a57a6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=356; TOXICOLOGICAL_EFFECT=reduced mean body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=IRIS:15645483:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_034754046264971441bb237e2acd394a
ToxValDB_IRIS RfD =0.05 mg/kg bw/day Human oral - Toxicity Value LONG_REF=NTP (National Toxicology Program). 1982. NTP Technical report on the carcinogenesis bioassay of bisphenol A (CAS No. 80-05-7) in F344 rats and B6C3F1 mice (feed study). NTP?80-35. NIH Publ. No. 82-1771; TITLE=NTP Technical report on the carcinogenesis bioassay of bisphenol A (CAS No. 80-05-7) in F344 rats and B6C3F1 mice (feed study); AUTHOR=NTP (National Toxicology Program); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a57a6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=356; TOXICOLOGICAL_EFFECT=Reduced mean body weight in male/female rats; STUDY_GROUP=IRIS:15644445:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1ed53a09770a8e2b09237a62217a5cca
ToxValDB_RSL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_RSL RfD =0.6 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663206:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cf7f50a6c967c543e7ac6dfed1d6f7fe
ToxValDB_ToxRefDB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ToxRefDB LEL =160 mg/kg bw/day Rat oral short-term (developmental); 10 days reproduction developmental LONG_REF=NTP (1985) Teratologic evaluation of bisphenol A administered to CDAR rats on gestation days 6 through 15. NTP-85-089; TITLE=Teratologic evaluation of bisphenol A administered to CDAR rats on gestation days 6 through 15; AUTHOR=NTP; EXTERNAL_SOURCE_ID=2612; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-pica|systemic: in life observation-clinical signs-lethargy|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-piloerection|systemic: in life observation-clinical signs-fur (altered appearance); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15695545_15695546:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a026ab6e122e3c2c4dce22cae7dbca56
ToxValDB_ToxRefDB LEL >1280 mg/kg bw/day Rat oral short-term (developmental); 10 days developmental LONG_REF=NTP (1985) Teratologic evaluation of bisphenol A administered to CDAR rats on gestation days 6 through 15. NTP-85-089; TITLE=Teratologic evaluation of bisphenol A administered to CDAR rats on gestation days 6 through 15; AUTHOR=NTP; EXTERNAL_SOURCE_ID=2612; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ToxRefDB_dup_-_15695547_15695548_15695549_15695550:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a62d1ffb2ec6368ecce2ec3c640ff906
ToxValDB_Uterotrophic_Hershberger_DB 24 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Uterotrophic_Hershberger_DB LEL =0.0008 mg/day Mouse injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713836:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5445888e67bbfacc956a0c0671301676
ToxValDB_Uterotrophic_Hershberger_DB LEL =0.00228291 mg Mouse injection acute; 0.17 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713696:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25ccf35863bd4424fc291290fd894e85
ToxValDB_Uterotrophic_Hershberger_DB LEL =0.2 mg/kg bw/day Mouse injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713495_15713649_15714000:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e4d014dbb15f708b446d8a89f48b49d
ToxValDB_Uterotrophic_Hershberger_DB LEL =0.5 mg/kg bw/day Rat injection short-term; 4 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15714003:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3613049237bd3f203b9ddb1055d4de65
ToxValDB_Uterotrophic_Hershberger_DB LEL =0.8 mg/day Mouse injection short-term; 4 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713338:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e5a5ff89521e085bee47da75446b5e40
ToxValDB_Uterotrophic_Hershberger_DB LEL =2 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_91efff6b16c72961b303c51a8ede3eff
ToxValDB_Uterotrophic_Hershberger_DB LEL =5 mg/kg bw/day Mouse injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713495_15713649_15714000:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_14cbec1b32ca197eb47343fab73277d9
ToxValDB_Uterotrophic_Hershberger_DB LEL =7.5 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1bc6e6e9863a94aedd563e524adadb3e
ToxValDB_Uterotrophic_Hershberger_DB LEL =8 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f7d3dac1157288beab9871381bf55b89
ToxValDB_Uterotrophic_Hershberger_DB LEL =10 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_578171280b87c194165da53b48e89e8e
ToxValDB_Uterotrophic_Hershberger_DB LEL =11 mg/kg bw/day Rat injection short-term; 7 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713519:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e530fdd778d11c77a0ef877283b169f
ToxValDB_Uterotrophic_Hershberger_DB LEL =20 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5b1a923a32cadb592bb1bc0b830f208c
ToxValDB_Uterotrophic_Hershberger_DB LEL =30 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7c95f4da426ff66e2b74e7116a0b1c64
ToxValDB_Uterotrophic_Hershberger_DB LEL =40 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7d67cffdfcf94f10a20937e5aacdb0f1
ToxValDB_Uterotrophic_Hershberger_DB LEL =50 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0 |::| 1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a115ffd7c87497d93c0d0c19aeb3012
ToxValDB_Uterotrophic_Hershberger_DB LEL =75 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_55178fbb3df18f797227417478f87a9b
ToxValDB_Uterotrophic_Hershberger_DB LEL =100 mg/kg bw/day Mouse injection short-term; 4 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713597:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7b03eb65c3624205b50c88a1c8627919
ToxValDB_Uterotrophic_Hershberger_DB LEL =150 mg/kg bw/day Rat lactation short-term; 7 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713622:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef9c583174dd8d812b9fb99af25054c9
ToxValDB_Uterotrophic_Hershberger_DB LEL =160 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bcef2f977a0a683716ef1b2240918bbd
ToxValDB_Uterotrophic_Hershberger_DB LEL =200 mg/kg bw/day Rat injection short-term; 2 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713631:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f4e8383505288db1f7a53455b6870eb
ToxValDB_Uterotrophic_Hershberger_DB LEL =300 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0 |::| 1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_774b4dd735700301afc4113b3cc4c4d6
ToxValDB_Uterotrophic_Hershberger_DB LEL =400 mg/kg bw/day Rat oral short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713627_15713633_15713663_15713681:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4eb6fd237ae7591b1d7148082b44714b
ToxValDB_Uterotrophic_Hershberger_DB LEL =600 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cbdf84c04fb6249fda52f5eb95eb975f
ToxValDB_Uterotrophic_Hershberger_DB LEL =800 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5527cd655dfda6ae351b9ba6f08d8c77
UnifiedCodex:SCCS_SHADOW:beta.noael_studies 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
UnifiedCodex:SCCS_SHADOW:beta.noael_studies reproductive toxicity 1 - rat - developmental reproductive toxicity SOURCE_SUBDIR=sccs_o_240; REPORT_TITLE=Final Opinion Scientific Committee on Consumer Safety SCCS OPINION ON the safety of presence of Bisphenol A in clothing articles; OPINION_NUMBER=SCCS/1620/20; COMMITTEE=Scientific Committee on Consumer Safety (SCCS); REPORT_DATE=31 March 2021; VALUE_TEXT=unclear:ot a skin irritant, but it can lead to serious eye damage (Eye Dam. 1), is able to elicit skin sensitization (Skin Sens. 1) and may cause respiratory irritation (STOT SE 3) (ECHA 2017). BPA has low acute toxicity for all routes of exposure relevant to human health (EFSA 2015). BPA has been found to affect kidney and liver weight in parental animals and in all the generations of rats and mice examined in multi-generation studies. EFSA considered these effects as relevant systemic effects for the identification of a NOAEL in their risk assessment. In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose. Liver weight was increased in rats (relative weight) and mice (both absolute and relative weight). The latter species also showed hepatocellular hypertrophy (EFSA 2015). Reproductive and developmental effects BPA is classified as toxic for reproduction (Repr. 1B) (ECHA 2017). Exposure to BPA at the adult stage alters the endocrine steroidogenic function of the ovary and more specifically the pro; DOSE=In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose.; EFFECT=ot a skin irritant, but it can lead to serious eye damage (Eye Dam. 1), is able to elicit skin sensitization (Skin Sens. 1) and may cause respiratory irritation (STOT SE 3) (ECHA 2017). BPA has low acute toxicity for all routes of exposure relevant to human health (EFSA 2015). BPA has been found to affect kidney and liver weight in parental animals and in all the generations of rats and mice examined in multi-generation studies. EFSA considered these effects as relevant systemic effects for the identification of a NOAEL in their risk assessment. In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose. Liver weight was increased in rats (relative weight) and mice (both absolute and relative weight). The latter species also showed hepatocellular hypertrophy (EFSA 2015). Reproductive and developmental effects BPA is classified as toxic for reproduction (Repr. 1B) (ECHA 2017). Exposure to BPA at the adult stage alters the endocrine steroidogenic function of the ovary and more specifically the pro; CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"80-05-7","citation":"","dose":"In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose.","duration":"developmental","effect":"ot a skin irritant, but it can lead to serious eye damage (Eye Dam. 1), is able to elicit skin sensitization (Skin Sens. 1) and may cause respiratory irritation (STOT SE 3) (ECHA 2017). BPA has low acute toxicity for all routes of exposure relevant to human health (EFSA 2015). BPA has been found to affect kidney and liver weight in parental animals and in all the generations of rats and mice examined in multi-generation studies. EFSA considered these effects as relevant systemic effects for the identification of a NOAEL in their risk assessment. In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose. Liver weight was increased in rats (relative weight) and mice (both absolute and relative weight). The latter species also showed hepatocellular hypertrophy (EFSA 2015). Reproductive and developmental effects BPA is classified as toxic for reproduction (Repr. 1B) (ECHA 2017). Exposure to BPA at the adult stage alters the endocrine steroidogenic function of the ovary and more specifically the pro","endpoint":"reproductive toxicity","ingredient":"s, toys, textiles, clothing,","loael_value":"","noael_unit":"","noael_value":"unclear:ot a skin irritant, but it can lead to serious eye damage (Eye Dam. 1), is able to elicit skin sensitization (Skin Sens. 1) and may cause respiratory irritation (STOT SE 3) (ECHA 2017). BPA has low acute toxicity for all routes of exposure relevant to human health (EFSA 2015). BPA has been found to affect kidney and liver weight in parental animals and in all the generations of rats and mice examined in multi-generation studies. EFSA considered these effects as relevant systemic effects for the identification of a NOAEL in their risk assessment. In mice, the increased kidney weight was associated with nephropathy at the highest BPA dose. Liver weight was increased in rats (relative weight) and mice (both absolute and relative weight). The latter species also showed hepatocellular hypertrophy (EFSA 2015). Reproductive and developmental effects BPA is classified as toxic for reproduction (Repr. 1B) (ECHA 2017). Exposure to BPA at the adult stage alters the endocrine steroidogenic function of the ovary and more specifically the pro","page":28,"route":"","species":"rat","study_id":"sccs_o_240_noael_001"}
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier MLT3645I99 UNII - - - chemical {"approval_status":null,"molecular_formula":"C15H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"MLT3645I99"}
openFDA substances FDA UNII substance identifier MLT3645I99 UNII - - - chemical {"approval_status":null,"molecular_formula":"C15H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"MLT3645I99"}
openFDA substances FDA UNII substance identifier MLT3645I99 UNII - - - chemical {"approval_status":null,"molecular_formula":"C15H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"MLT3645I99"}
openFDA substances FDA UNII substance identifier MLT3645I99 UNII - - - chemical {"approval_status":null,"molecular_formula":"C15H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"MLT3645I99"}