Moderate Cosmetic Ingredient NOAEL Data GHS Classified

4,4'-ISOPROPYLIDENEDIPHENOL

CAS Number

80-05-7

Function

Not Reported

Safety Rating

MODERATE

Regulatory Status

🇪🇺 EU Status Restricted

EU Max Conc. II/1176 CMR 1B

🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

8 study endpoints found for 4,4'-ISOPROPYLIDENEDIPHENOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOEL	30 ppm	oral	mouse	oral	REACH
NOEL	75 ppm	oral	rat	oral	REACH
NOAEL	>90 2106	1993	rat	inhalation	REACH
LOAEL	600 mg/kg bw/day	oral	rat	oral	REACH
LOAEL	25000 other	oral	rat	oral	REACH
LOAEL	250 ppm	oral	code:3544	oral	REACH
LOAEL	1000 ppm	oral	code:3544	oral	REACH
BMDL10	8.9 mg/kg bw/day	oral	-	oral	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

WARNING

Pictograms

excl mark;warn; cancer;health haz

Hazard Statements

Causes serious eye irritation May cause an allergic skin reaction Suspected of damaging fertility or the unborn child May cause respiratory irritation Toxic to aquatic life

Short-term Exposure Effects

The substance is severely irritating to the eyes. The substance is mildly irritating to the respiratory tract.

Long-term Exposure Effects

Repeated or prolonged contact may cause skin sensitization and photosensitization. The substance may have effects on the upper respiratory tract. Ingestion may cause effects on the liver and kidneys. Animal tests show that this substance possibly causes toxic effects upon human reproduction.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its aerosol.

Expert Verdict

4,4'-ISOPROPYLIDENEDIPHENOL is listed in the EU CosIng database with functions: Not Reported It is restricted under EU Cosmetics Regulation. Restriction: II/1176 CMR 1B.

⚠️

Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted needs-enrichment prop65 eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 4,4'-ISOPROPYLIDENEDIPHENOL safe in cosmetics?

4,4'-ISOPROPYLIDENEDIPHENOL is listed in the EU CosIng database with functions: Not Reported It is restricted under EU Cosmetics Regulation. Restriction: II/1176 CMR 1B. The EU classifies 4,4'-ISOPROPYLIDENEDIPHENOL as "Restricted". Safety rating: MODERATE. 8 toxicological study endpoint(s) are available in our database.

Is 4,4'-ISOPROPYLIDENEDIPHENOL allowed in the EU?

4,4'-ISOPROPYLIDENEDIPHENOL EU regulatory status: Restricted. Maximum allowed concentration: II/1176 CMR 1B. This is based on EU Regulation 1223/2009 and its amendments.

What does 4,4'-ISOPROPYLIDENEDIPHENOL do in cosmetics?

4,4'-ISOPROPYLIDENEDIPHENOL functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 80-05-7.

What is the NOAEL for 4,4'-ISOPROPYLIDENEDIPHENOL?

The NOAEL (No Observed Adverse Effect Level) for 4,4'-ISOPROPYLIDENEDIPHENOL is 30 ppm based on a oral study via oral route in mouse. A total of 8 study endpoints are available. Source: REACH.

Is 4,4'-ISOPROPYLIDENEDIPHENOL classified as hazardous under GHS?

4,4'-ISOPROPYLIDENEDIPHENOL carries a GHS signal word of "WARNING". Hazard statements: Causes serious eye irritation May cause an allergic skin reaction Suspected of damaging fertility or the unborn child May cause respiratory irritation Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check 4,4'-ISOPROPYLIDENEDIPHENOL compliance across multiple jurisdictions:

🔬

Ingredient Decoder

Paste a full ingredient list for instant analysis

🌸

82 Allergen Checker

Check for EU declarable fragrance allergens

🧪

Substance Compliance

Check compliance across 55 jurisdictions

🧮

MoS Calculator

Calculate Margin of Safety using SCCS methodology

⚗️

Heavy Metal Limits

Compare limits across jurisdictions

Related Ingredients

CARBONIC ACID

Good

INDIGOFERA ARGENTEA LEAF POWDER

Good

OLEAMIDOPROPYL DIMETHYLAMINE

Good

(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT

Good

NEPETA CATARIA

Good

Browse all 30,000+ ingredients →

📱

Is 4,4'-ISOPROPYLIDENEDIPHENOL in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 4,4'-ISOPROPYLIDENEDIPHENOL in your formulation.

Ingredient Decoder MoS Calculator