Moderate Cosmetic Ingredient NOAEL Data GHS Classified

4,4'-ISOPROPYLIDENEDIPHENOL

Also known as: BPA, 4,4’-Propane-2,2-diyldiphenol, Phenol, 4,4'-(1-methylethylidene)bis-, 4-06-00-06717, 2,2-Bis(hydroxyphenyl)propane (+15 more)

4,4'-ISOPROPYLIDENEDIPHENOL (CAS 80-05-7) is a cosmetic cosmetic ingredient functioning as Not Reported. NOAEL 90 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max II/1176 CMR 1B; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 80-05-7 →

Auto-generated CPSR Part A draft with source citations

Cross-Vertical Regulatory Divergence

4,4'-ISOPROPYLIDENEDIPHENOL is classified GHS Danger (H317, H318, H335, H360, H361, H411, H361f, H303) in the chemicals database but is restricted in EU cosmetics at max II/1176 CMR 1B.

Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

CAS Number

80-05-7

View industrial chemical safety profile →

Function

Not Reported

Safety Rating

MODERATE

Chemistry & Identifiers

Formula

C15H16O2

228.29 g/mol

EC Number

201-245-8

PubChem CID

6623

IUPAC Name

4-[2-(4-hydroxyphenyl)propan-2-yl]phenol

InChIKey

IISBACLAFKSPIT-UHFFFAOYSA-N

ChEBI: CHEBI:33216 UNII: MLT3645I99 Wikidata: Q271980

Regulatory Status

EU EU Status restricted

EU Max Conc. II/1176 CMR 1B

US US Status Not specifically regulated

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Toxicological Studies

2 study endpoints found for 4,4'-ISOPROPYLIDENEDIPHENOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	=50 mg/kg bw/day	oral	Rat	reproduction developmental	ToxValDB_ECHA_IUCLID
NOAEL	=150 mg/kg bw/day	oral	Rat	developmental	ToxValDB_ECHA_IUCLID

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

WARNING

Pictograms

Excl markWarnCancerHealth haz

Hazard Statements

Causes serious eye irritation May cause an allergic skin reaction Suspected of damaging fertility or the unborn child May cause respiratory irritation Toxic to aquatic life

Short-term Exposure Effects

The substance is severely irritating to the eyes. The substance is mildly irritating to the respiratory tract.

Long-term Exposure Effects

Repeated or prolonged contact may cause skin sensitization and photosensitization. The substance may have effects on the upper respiratory tract. Ingestion may cause effects on the liver and kidneys. Animal tests show that this substance possibly causes toxic effects upon human reproduction.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its aerosol.

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for 4,4'-ISOPROPYLIDENEDIPHENOL across SCCS product categories, with measured dermal absorption where available.

EPA ToxValDB — Toxicity Values

10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).

Endpoint	Value	Species	Route	Duration	Source
LD50	>5000 mg/kg	Rabbit	dermal	acute	ECHA IUCLID
LD50	>5000 mg/kg	Rat	oral	-	ECHA IUCLID
NOAEL	=150 mg/kg-day	Rat	oral	-	ECHA IUCLID
NOAEL	=50 mg/kg-day	Rat	oral	-	ECHA IUCLID
NOAEL	=50 mg/kg-day	Rat	oral	-	ECHA IUCLID
NOAEL	=50 mg/kg-day	Rat	oral	-	ECHA IUCLID
NOAEL	>=150 mg/kg-day	Rat	oral	-	ECHA IUCLID
NOAEC	=10 mg/m3	Rat	inhalation	subchronic	EU SCOEL
OEL	=2 mg/m3	Human	inhalation	-	EU SCOEL
LOEL	=200 mg/kg-day	Rat	oral	short-term	ECOTOX

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Signal Word

Danger

Pictograms

Health HazardHarmful / IrritantCorrosiveEnvironmental Hazard

Hazard Class and Category

Repr. 1B; STOT SE 3; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1

Hazard Statements

H360F
H335 May cause respiratory irritation
H318 Causes serious eye damage
H317 May cause an allergic skin reaction
H400 Very toxic to aquatic life
H410 Very toxic to aquatic life with long lasting effects

Specific Concentration Limits / M-factors

M = 1; M = 10

Inserted via ATP: ATP18

Endocrine Disruptor Evidence (Expanded)

Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.

Confirmed Evidence: High (2017)

Health effects: Yes

Affected pathways: Estrogenic (ERα/ERβ), Anti-androgenic

Regulatory framework: REACH

Source list: I

Cosmetic-Specific Mechanism

Category: bisphenol

Receptor targets: ERα, ERβ, AR, TR, GPER, ERRγ, PPARγ

LOEC: 1 nM

EU status: banned in cosmetics; SVHC REACH (health + environment)

agonist (ER, GPER, ERRγ); antagonist (AR, TR)

Dose-Response Data Points

Endpoint	Target	Value	Direction
toxic_dose	general	2 µg/kg/day µg/kg/day	-
dermal_flux	skin	0.022 µg/cm²/h	-
dermal_absorption	skin	16–20% %	-
ERE-driven luciferase	ERa/ERb	EC50/IC50: EC50 (logEC50 -6.679 M) = ~0.21 uM; LOEC: ~0.01 uM; NOEC: 0.001 uM mixed	agonist
Beta-galactosidase reporter	ER	EC50/IC50: EC50 ~0.1-1 uM; LOEC: ~0.01 uM; NOEC: 0.001 uM mixed	agonist
ERE reporter, cell proliferation	ERa	EC50/IC50: ~1 nM (full response curve); LOEC: 0.1 nM; NOEC: 0.01 nM mixed	agonist

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

1,000,000 - 10,000,000 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

Yes (since 12-Jan-2017)

Hazard classification: Restricted (Annex XVII)

SVHC reason: Toxic for reproduction (Article 57c)

Substance of Very High Concern (SVHC)

Included: 12-Jan-2017

Toxic for reproduction (Article 57c); Endocrine disrupting properties (Article 57(f) - environment); Endocrine disrupting properties (Article 57(f) - human health)

EU CosIng Annex Listing

European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.

Annex II — Prohibited

Ref: 1176

(EC) 2009/1223

CMR: Reprotoxic Cat. 1B()

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

SA Saudi SFDA (II - Prohibited)

ASEAN Cosmetic Directive (II)

Ref: 1176

BRIN Brazil/India Cosmetics

Brazil: Prohibited

India: Prohibited (GNRAS)

Additional Jurisdictional Restrictions (1)

Jurisdiction	Status	Max %	Product Type
CA	banned	-	-

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (5)

Carcinogen Classification

No indication of carcinogenicity to humans (not listed by IARC).

Source: Toxin and Toxin Target Database (T3DB)

Carcinogen Classification

Bisphenol A | TR-215: Carcinogenesis Bioassay of Bisphenol A (CASRN 80-05-7) in F344 Rats and B6C3F1 Mice (Feed Study) (1982 ) | 10/15/80 | Equivocal Evidence | Equivocal Evidence | Equivocal Evidence | No Evidence | Under the conditions of this bioassay, there was no convincing evidence that bisphenol A was carcinogenic for F344 rats or B6C3F1 mice of either sex.

Source: NTP Technical Reports

Endocrine Disruptors

Potential endocrine disrupting compound

Source: NORMAN Suspect List Exchange

ICSC Safety Card

0634

Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Skin Eye Respiratory Irritation

The substance is severely irritating to the eyes. The substance is mildly irritating to the respiratory tract.

Source: Hazardous Substances Data Bank (HSDB)

Function Categories & List Membership

Cosmetic/Chemical Function Categories

Antioxidant Binder Catalyst Flame retardant Hardener Monomers No specific technical function

Regulatory List Membership (4)

California Proposition 65 (OEHHA) EU Banned in Cosmetics FDA Indirect Food Contact Additives EU CosIng Cosmetics Ingredient Database

Expert Verdict

Expert safety assessment and concern-level summary for 4,4'-ISOPROPYLIDENEDIPHENOL.

Regulatory Flags

cosing-sourced eu-restricted needs-enrichment prop65 eu_banned_cosmetics eu_cosing_listed

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to 4,4'-ISOPROPYLIDENEDIPHENOL by CAS number or substance name.

Studies

Lowest NOAEL

0.025 mg/kg bw/day

Highest NOAEL

640 mg/kg bw/day

ToxValDB_ECHA_IUCLID ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip

Known Synonyms

BPA 4,4’-Propane-2,2-diyldiphenol Phenol, 4,4'-(1-methylethylidene)bis- 4-06-00-06717 2,2-Bis(hydroxyphenyl)propane BRN 1107700 beta-Di-p-hydroxyphenylpropane EINECS 201-245-8 NCI-C50635 Phenol, 4,4'-dimethylmethylenedi- Phenol, (1-methylethylidene)bis- Propane, 2,2-bis(p-hydroxyphenyl)- UNII-MLT3645I99 (1-methylethylidene)bis-Phenol 1,1'-(1-Methylethylidene)bisphenylol, 9CI 2, 2-Bis(4-hydroxyphenyl)propane 2, 2-Bis(hydroxyphenyl)propane 2, 2-Di(4-phenylol)propane 2,2'-Bis(4-hydroxyphenyl)propane 2,2-(4,4'-Dihydroxydiphenyl)propane

Chemical Function

Binder Hardener

Regulatory Lists

drinking_water; Europe; manufacturing; plastic_additive detected; Toys and children's products active_ingredient; Pesticides Cons electronics mech appliances and machinery; Europe CEDI Indirect additives food contact (10/2018) detected; wastewater detected; Europe; Toys and children's products detected; Europe; Toys and children's products Europe; nondetect; Other direct contact consumer goods Europe; nondetect; Other direct contact consumer goods detected; Europe; Other direct contact consumer goods detected; Europe; Other direct contact consumer goods artificial_sweat; detected; emissions; Europe; Other direct contact consumer goods detected; Europe; Other direct contact consumer goods detected; Europe; Other direct contact consumer goods detected; MN Chemical Screening; surface_water detected; MN Chemical Screening; surface_water

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound

BISPHENOL A

ChEMBL ID

CHEMBL418971

View full pharmaceutical profile →

Frequently Asked Questions

Is 4,4'-ISOPROPYLIDENEDIPHENOL safe in cosmetics?

4,4'-ISOPROPYLIDENEDIPHENOL has a safety rating of "MODERATE" in our database. EU status: restricted. 2 toxicological study endpoint(s) are available in our database.

Is 4,4'-ISOPROPYLIDENEDIPHENOL allowed in the EU?

4,4'-ISOPROPYLIDENEDIPHENOL EU regulatory status: restricted. Maximum allowed concentration: II/1176 CMR 1B. This is based on EU Regulation 1223/2009 and its amendments.

What does 4,4'-ISOPROPYLIDENEDIPHENOL do in cosmetics?

4,4'-ISOPROPYLIDENEDIPHENOL functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 80-05-7.

What is the NOAEL for 4,4'-ISOPROPYLIDENEDIPHENOL?

The NOAEL (No Observed Adverse Effect Level) for 4,4'-ISOPROPYLIDENEDIPHENOL is =50 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.

Is 4,4'-ISOPROPYLIDENEDIPHENOL classified as hazardous under GHS?

4,4'-ISOPROPYLIDENEDIPHENOL carries a GHS signal word of "WARNING". Hazard statements: Causes serious eye irritation May cause an allergic skin reaction Suspected of damaging fertility or the unborn child May cause respiratory irritation Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Is 4,4'-ISOPROPYLIDENEDIPHENOL used outside cosmetics?

4,4'-ISOPROPYLIDENEDIPHENOL also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does 4,4'-ISOPROPYLIDENEDIPHENOL have different safety status in cosmetics vs industrial chemicals?

4,4'-ISOPROPYLIDENEDIPHENOL is classified GHS Danger (H317, H318, H335, H360, H361, H411, H361f, H303) in the chemicals database but is restricted in EU cosmetics at max II/1176 CMR 1B.

Compliance Tools

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