NOAEL Studies Cosmetic Ingredient

4-Amino-3-Nitrophenol NOAEL Studies

INCI: 4-AMINO-3-NITROPHENOL

CAS: 610-81-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 10 mg/kg bw/day rat oral 91 day Subchronic SCCP; S-A. Brownlie. Imexine FN: 13-Week Oral (Gavage) Toxicity Study in the Rat.Quintiles Study No. LRL/77/95, 1997
NTP ICE skin sensitization 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization EC3 0.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13137; Record_ID=skin_sensitization_invivo_3154; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID50209864; Assay=LLNA; Endpoint=EC3; Response=0.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID50209864
SCCS Opinion 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.01 mg/kg rat oral 13-week dermal absorption p.23
SCCS Opinion NOAEL =0.061 mg/kg rat oral 13-week dermal absorption p.23
SCCS Opinion NOAEL =20 mg/kg bw - - developmental developmental toxicity p.22
SCCS Opinion NOAEL =50 mg/kg bw - - - NOAEL study p.14
SCCS Opinion NOAEL =60 mg/kg bw rat oral 13-week dermal absorption p.23
SCCS Opinion NOAEL =100 mg/kg bw - - - NOAEL study Ref.: 12 New study Guideline: OECD 414, p.21
SCCS Opinion NOAEL =250 mg/kg bw - oral Sub-chronic repeated dose toxicity Ref.: 5 of submission I 3, p.14
SCCS Opinion NOAEL =400 mg/kg/day - oral developmental developmental toxicity p.22
Regulatory source 14 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 50 mg/kg bw - - - - p.14
Regulatory source - 100 mg/kg bw - - - - p.21
Regulatory source - 100 mg/kg bw rat oral - - p.22
Regulatory source - 250 mg/kg bw - - - - p.14
Regulatory source dermal absorption =0.01 mg/kg rat oral 13-week dermal absorption p.23
Regulatory source dermal absorption =0.061 mg/kg rat oral 13-week dermal absorption p.23
Regulatory source dermal absorption =60 mg/kg bw rat oral 13-week dermal absorption p.23
Regulatory source developmental toxicity 20 mg/kg bw - - developmental developmental toxicity p.22
Regulatory source developmental toxicity 100 mg/kg bw rat oral 28 day developmental toxicity p.23
Regulatory source developmental toxicity 250 mg/kg bw rat oral 28 day developmental toxicity p.23
Regulatory source developmental toxicity 400 mg/kg/day - oral developmental developmental toxicity p.22
Regulatory source genotoxicity 50 mg/kg bw - - Chronic genotoxicity p.15
Regulatory source genotoxicity 250 mg/kg bw - - Chronic genotoxicity p.15
Regulatory source repeated dose toxicity 250 mg/kg bw - oral Sub-chronic repeated dose toxicity p.14
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier R5WY41Q95Z UNII - - - chemical -