Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for 4-Amino-3-Nitrophenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 10 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Must not be used with nitrosating agents. Mandatory warnings: not for under-16; patch test advisory; hair colorants can cause severe allergic reactions.
Regulatory Flags
Frequently Asked Questions
Is 4-Amino-3-Nitrophenol safe in cosmetics?
Must not be used with nitrosating agents. Mandatory warnings: not for under-16; patch test advisory; hair colorants can cause severe allergic reactions. The EU classifies 4-Amino-3-Nitrophenol as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is 4-Amino-3-Nitrophenol allowed in the EU?
4-Amino-3-Nitrophenol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Amino-3-Nitrophenol do in cosmetics?
4-Amino-3-Nitrophenol functions as: Hair Dyeing (oxidative and non-oxidative hair dye). It is classified as a cosmetic ingredient in our database. CAS number: 610-81-1.
What is the Margin of Safety for 4-Amino-3-Nitrophenol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 4-Amino-3-Nitrophenol?
The NOAEL (No Observed Adverse Effect Level) for 4-Amino-3-Nitrophenol is 10 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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