NOAEL Studies Cosmetic Ingredient

4-Amino-M-Cresol NOAEL Studies

INCI: 4-AMINO-M-CRESOL

CAS: 2835-99-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 120 mg/kg bw/day rat oral 91 day Subchronic SCCP; Sterner, W.; Korn, W.-D.; Three month toxicity study with Oxyrot after repeated oraladministration to rats; IBR; 21.12.1984
COSMOS DB NOAEL 60 mg/kg bw/day rat oral 91 day Subchronic SCCP; Sterner, W.; Korn, W.-D.; Three month toxicity study with Oxyrot after repeated oraladministration to rats; IBR; 21.12.1984
NTP ICE skin sensitization 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD86, EC150 1.03 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8267; Record_ID=skin_sensitization_invitro_2290; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2049262; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=8.36038961; Reported_Response_Unit=uM; Conversion_Factor_Value=123.155; Conversion_Factor_Source=EPA Dashboard; Converted_Response=1.03; Converted_Response_Unit=ug/mL; Response=1.03; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2049262
NTP ICE skin sensitization Depletion Cys 90 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=123; Record_ID=skin_sensitization_invitro_38; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2049262; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=90; Reported_Response_Unit=%; Response=90; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2049262
NTP ICE skin sensitization Depletion Lys 28.8 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=173; Record_ID=skin_sensitization_invitro_38; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2049262; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=28.8; Reported_Response_Unit=%; Response=28.8; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2049262
NTP ICE skin sensitization EC1.5 5.278 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=8802; Record_ID=skin_sensitization_invitro_2437; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2049262; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=5.277549079; Reported_Response_Unit=uM; Response=5.278; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2049262
NTP ICE skin sensitization EC3 1.5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13113; Record_ID=skin_sensitization_invivo_3115; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID2049262; Assay=LLNA; Endpoint=EC3; Response=1.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2049262
NTP ICE skin sensitization IC50 77.67 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=8803; Record_ID=skin_sensitization_invitro_2437; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2049262; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=77.67494303; Reported_Response_Unit=uM; Response=77.67; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2049262
NTP ICE skin sensitization Imax 7.609 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=8805; Record_ID=skin_sensitization_invitro_2437; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2049262; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=7.608534599; Reported_Response_Unit=Unitless; Response=7.609; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2049262
SCCS Opinion 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =60 mg/kg rat oral subchronic repeated dose toxicity p.24
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =1.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629724:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ed43f9c8a6f712d6e4f5c5db094f84b7
Regulatory source 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source repeated dose toxicity =60 mg/kg rat oral subchronic repeated dose toxicity p.24
Regulatory source repeated dose toxicity 60 mg/kg bw/day rat oral subchronic repeated dose toxicity p.24
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 12R07I1K8C UNII - - - chemical -