Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for 4-Amino-M-Cresol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 60 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 120 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Prohibited in EU. Permitted in US as oxidative hair dye ingredient. Must carry mandatory warning: Can cause allergic reaction. Not to be used for dyeing eyelashes or eyebrows unless specifically permitted. Must not exceed 1.5% on-head concentration.
Regulatory Flags
Frequently Asked Questions
Is 4-Amino-M-Cresol safe in cosmetics?
Prohibited in EU. Permitted in US as oxidative hair dye ingredient. Must carry mandatory warning: Can cause allergic reaction. Not to be used for dyeing eyelashes or eyebrows unless specifically permitted. Must not exceed 1.5% on-head concentration. The EU classifies 4-Amino-M-Cresol as "prohibited". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is 4-Amino-M-Cresol allowed in the EU?
4-Amino-M-Cresol EU regulatory status: prohibited. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Amino-M-Cresol do in cosmetics?
4-Amino-M-Cresol functions as: Oxidative hair dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 2835-99-6.
What is the Margin of Safety for 4-Amino-M-Cresol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 4-Amino-M-Cresol?
The NOAEL (No Observed Adverse Effect Level) for 4-Amino-M-Cresol is 60 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check 4-Amino-M-Cresol compliance across multiple jurisdictions:
Related Ingredients
Is 4-Amino-M-Cresol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 4-Amino-M-Cresol in your formulation.