NOAEL Studies Cosmetic Ingredient

4-Chlororesorcinol NOAEL Studies

INCI: 4-CHLORORESORCINOL

CAS: 95-88-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 100 mg/kg bw/day rat oral 6-20 Gestation day Developmental SCCS; Marburger, A., Flade D. (2005). Prenatal Developmental Toxicity Study in the HanWistar Rat. RCC Ltd, Itingen, Switzerland, internal study code: 854669. Archive codeat Henkel KGaA, Düsseldorf, Report No. R 0500030
COSMOS DB NOAEL 50 mg/kg bw/day rat oral 6-20 Gestation day Developmental SCCS; Marburger, A., Flade D. (2005). Prenatal Developmental Toxicity Study in the HanWistar Rat. RCC Ltd, Itingen, Switzerland, internal study code: 854669. Archive codeat Henkel KGaA, Düsseldorf, Report No. R 0500030
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =369 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_11776; row=14565; data_type=In Vivo; mixture=Chemical; chemical_name=4-Chlororesorcinol; preferred_name=4-Chlororesorcinol; dtxsid=DTXSID8052643; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8052643; source_file=acute_oral.xlsx
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.08 mg/kg rat oral - dermal absorption p.23
SCCS Opinion NOAEL =0.106 mg/kg rat oral - dermal absorption p.23
SCCS Opinion NOAEL =50 mg/kg bw/d human - - NOAEL study p.22
SCCS Opinion NOAEL =50 mg/kg/d rat oral - dermal absorption p.23
SCCS Opinion NOAEL =200 mg/kg bw/d human - - NOAEL study p.22
SCCS Opinion NOAEL =210 mg/kg bw/d rat oral Chronic genotoxicity p.16
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =4.996 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630696:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a0dd2ae7e83d12b71ed0bdf9235e3fcd
Regulatory source 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 50 mg/kg bw/d human - - - p.22
Regulatory source - 200 mg/kg bw/d human - - - p.22
Regulatory source dermal absorption =0.08 mg/kg rat oral - dermal absorption p.23
Regulatory source dermal absorption =0.106 mg/kg rat oral - dermal absorption p.23
Regulatory source dermal absorption =50 mg/kg/d rat oral - dermal absorption p.23
Regulatory source genotoxicity 210 mg/kg bw/d rat oral Chronic genotoxicity p.16
Regulatory source repeated dose toxicity 50 mg/kg bw/d rat oral subchronic repeated dose toxicity p.23
Regulatory source repeated dose toxicity 200 mg/kg bw/d rat oral subchronic repeated dose toxicity p.23
Regulatory source repeated dose toxicity 210 mg/kg bw/d rat oral subchronic repeated dose toxicity p.23
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 87045U29QJ UNII - - - chemical -