NOAEL Studies Cosmetic Ingredient

4-Formyl-1-Methylquinolinium-P-Toluenesulfonate NOAEL Studies

INCI: 4-FORMYL-1-METHYLQUINOLINIUM-P-TOLUENESULFONATE

CAS: 223398-02-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 316 mg/kg bw/day rat oral 5-19 Gestation day Developmental SCCS; Amutha, S. (2002) Prenatal Developmental Toxicity Study of Moe-HM-6116-190 inRats by Oral Gavage. Jai Research Foundation, Department of Toxicology, Valvada,India, Study No. 3672. Henkel KGaA, Düsseldorf, Report No. R 0200657
COSMOS DB NOAEL 100 mg/kg bw/day rat oral 5-19 Gestation day Developmental SCCS; Amutha, S. (2002) Prenatal Developmental Toxicity Study of Moe-HM-6116-190 inRats by Oral Gavage. Jai Research Foundation, Department of Toxicology, Valvada,India, Study No. 3672. Henkel KGaA, Düsseldorf, Report No. R 0200657
COSMOS DB NOAEL 1000 mg/kg bw/day rat oral 91 day Subchronic SCCP; Mathews, M. (2003) Repeated Dose 90-Day Oral Toxicity Study of Moe-HM-6116-190in Rats Followed by a 4 Week Recovery Period (Vol. I - III). Jai Research Foundation,
SCCS Opinion 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.009 mg/kg bw/d rat oral - dermal absorption p.21
SCCS Opinion NOAEL =0.0297 mg/kg bw/d rat oral - dermal absorption p.21
SCCS Opinion NOAEL =100 mg/kg bw - oral - NOAEL study p.16
SCCS Opinion NOAEL =100 mg/kg bw/d rat oral - dermal absorption p.21
SCCS Opinion NOAEL =250 mg/kg bw/day - oral Chronic genotoxicity p.13
SCCS Opinion NOAEL =250 mg/kg bw rat oral 90 day NOAEL study p.21
SCCS Opinion NOAEL =1000 mg/kg bw - oral - NOAEL study p.16
SCCS Opinion NOAEL >2000 mg/kg bw rat oral 90 day irritation p.17
Regulatory source 11 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 100 mg/kg bw - oral - - p.16
Regulatory source - 250 mg/kg bw rat oral 90 day - p.21
Regulatory source - 1000 mg/kg bw - oral - - p.16
Regulatory source - >2000 mg/kg bw rat oral 90 day - p.21
Regulatory source dermal absorption =0.009 mg/kg bw/d rat oral - dermal absorption p.21
Regulatory source dermal absorption =0.0297 mg/kg bw/d rat oral - dermal absorption p.21
Regulatory source dermal absorption =100 mg/kg bw/d rat oral - dermal absorption p.21
Regulatory source dermal absorption 100 mg/kg bw rabbit dermal - dermal absorption p.22
Regulatory source genotoxicity 250 mg/kg bw/day - oral Chronic genotoxicity p.13
Regulatory source irritation 1000 mg/kg bw rat oral 90 day irritation p.17
Regulatory source irritation >2000 mg/kg bw rat oral 90 day irritation p.17