NOAEL Studies Cosmetic Ingredient

4-Hydroxypropylamino-3-Nitrophenol NOAEL Studies

INCI: 4-HYDROXYPROPYLAMINO-3-NITROPHENOL

CAS: 92952-81-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 10 mg/kg bw/day rat oral 91 day Subchronic SCCP; Husband, R.F.A and Newman, A.J. (1986). 13 Week Oral Toxicity Study in the Rat – WSI 72. Toxicol Laboratories Limited, Ledbury, England, internal study code SAK/10/C. Archive code at Henkel KGaA, Düsseldorf, Report No. R 9600327
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.02 mg/kg rat oral 90-day dermal absorption p.20
SCCS Opinion NOAEL =0.067 mg/kg rat oral 90-day dermal absorption p.20
SCCS Opinion NOAEL =10 mg/kg bw rat oral subchronic repeated dose toxicity p.5
SCCS Opinion NOAEL =30 mg/kg bw/day - - Chronic genotoxicity p.15
SCCS Opinion NOAEL =30 mg/kg rat oral 90-day dermal absorption p.20
SCCS Opinion NOAEL =90 mg/kg bw/day - - 4 weeks NOAEL study p.14
Regulatory source 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 10 mg/kg bw - - - - p.14
Regulatory source - 90 mg/kg bw/day - - 4 weeks - p.14
Regulatory source dermal absorption =0.02 mg/kg rat oral 90-day dermal absorption p.20
Regulatory source dermal absorption =0.067 mg/kg rat oral 90-day dermal absorption p.20
Regulatory source dermal absorption =30 mg/kg rat oral 90-day dermal absorption p.20
Regulatory source developmental toxicity 90 mg/kg bw/day rat - developmental developmental toxicity p.19
Regulatory source genotoxicity 30 mg/kg bw/day - - Chronic genotoxicity p.15
Regulatory source irritation 30 mg/kg bw/day rat - 13-week irritation p.21
Regulatory source repeated dose toxicity 10 mg/kg bw rat oral subchronic repeated dose toxicity p.5
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier X89W3M6X79 UNII - - - chemical -