NOAEL Studies Cosmetic Ingredient

4-Nitrophenyl Aminoethylurea NOAEL Studies

INCI: 4-NITROPHENYL AMINOETHYLUREA

CAS: 27080-42-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 1 mg/kg bw/day rat oral 91 day Subchronic SCCS; Ravel, G.; 4-Nitrophenyl Aminoethylurea (WR23348) - 13 week oral (gavage) toxicitystudy in the rat; MDS PHARMA SERVICES; 2005
SCCS Opinion 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.01 mg/kg bw/d rat oral 90-day dermal absorption p.26
SCCS Opinion NOAEL =5 mg/kg bw rat - Chronic genotoxicity p.18
SCCS Opinion NOAEL =5 mg/kg bw/d - - - NOAEL study p.17
SCCS Opinion NOAEL =50 mg/kg bw - - - NOAEL study p.22
SCCS Opinion NOAEL =125 mg/kg bw rat - Chronic genotoxicity p.18
Regulatory source 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 5 mg/kg bw/d - - - - p.17
Regulatory source - 50 mg/kg bw - - - - p.22
Regulatory source - 125 mg/kg bw - - - - p.17
Regulatory source dermal absorption =0.01 mg/kg bw/d rat oral 90-day dermal absorption p.26
Regulatory source dermal absorption =5 mg/kg bw/d rat oral 90-day dermal absorption p.26
Regulatory source developmental toxicity 50 mg/kg bw rat dermal - developmental toxicity p.24
Regulatory source developmental toxicity 50 mg/kg bw rat - - developmental toxicity p.26
Regulatory source genotoxicity 5 mg/kg bw rat - Chronic genotoxicity p.18
Regulatory source genotoxicity 125 mg/kg bw rat - Chronic genotoxicity p.18
Regulatory source repeated dose toxicity 5 mg/kg bw rat oral Sub-chronic repeated dose toxicity p.24
Regulatory source repeated dose toxicity 5 mg/kg bw/day rat oral sub-chronic repeated dose toxicity p.26
Regulatory source repeated dose toxicity 125 mg/kg bw rat oral Sub-chronic repeated dose toxicity p.24
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 1G48T8PRLV UNII - - - chemical -