NOAEL Studies
Cosmetic Ingredient
4-T-Butylcyclohexanol NOAEL Studies
INCI: 4-T-BUTYLCYCLOHEXANOL
CAS: 98-52-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
EFSA 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =2.5 | mg/kg bw/day | Dog | oral: unspecified | 365 days | chronic/long term toxicity | EFSA - 2010 - OutputID 1237 - histopathology non neoplastic - hepatotoxicity - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719 |
| EFSA | NOAEL | =10 | mg/kg bw/day | Rat | - | - | acute toxicity | EFSA - 2010 - OutputID 1237 - neurology - neurotoxicity - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719 |
| EFSA | NOAEL | =30 | mg/kg bw/day | Rat | - | 28 days | subchronic | EFSA - 2021 - OutputID 3927 - clinical signs - neurotoxicity - Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted - doi:10.2903/j.efsa.2021.6385 |
| EFSA | NOAEL | =31.5 | mg/kg bw/day | Rat | - | - | reproduction toxicity | EFSA - 2021 - OutputID 3927 - clinical signs - systemic - Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted - doi:10.2903/j.efsa.2021.6385 |
| EFSA | NOEL | =2.02 | mg/kg bw/day | Bobwhite quail | - | - | reproduction toxicity | EFSA - 2010 - OutputID 1237 - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719 |
| EFSA | NOEL | =9.19 | mg/kg bw/day | Rat | - | - | chronic/long term toxicity | EFSA - 2010 - OutputID 1237 - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719 |
| EFSA | NOEL | =10.6 | mg/kg bw/day | Mallard duck | - | - | reproduction toxicity | EFSA - 2010 - OutputID 1237 - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719 |
| EFSA | NOEL | =22.2 | mg/kg bw/day | Rat | - | - | chronic/long term toxicity | EFSA - 2010 - OutputID 1237 - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719 |
| EFSA | ADI | =0.025 | mg/kg bw/day | Consumers | - | - | ADI | EFSA - 2010 - OutputID 1237 - Consumers - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719 |
| EFSA | ADI | =0.03 | mg/kg bw/day | Consumers | - | - | ADI | EFSA - 2021 - OutputID 3927 - Consumers - Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted - doi:10.2903/j.efsa.2021.6385 |
| EFSA | ARfD | =0.1 | mg/kg bw | Consumers | - | - | ARfD | EFSA - 2010 - OutputID 1237 - Consumers - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719 |
| EFSA | ARfD | =0.1 | mg/kg bw/day | Consumers | - | - | ARfD | EFSA - 2021 - OutputID 3927 - Consumers - Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted - doi:10.2903/j.efsa.2021.6385 |
| EFSA | NOAEL | =30 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | LONG_REF=EFSA (2021). Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted. doi:10.2903/j.efsa.2021.6385.; TITLE=Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2021.6385; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=EFSA:15625575:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_37b6b1bd3535638c10111f698cc267a2 |
| EFSA | NOAEL | =31.5 | mg/kg bw/day | Rat | oral | - | reproduction developmental | LONG_REF=EFSA (2021). Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted. doi:10.2903/j.efsa.2021.6385.; TITLE=Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2021.6385; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=EFSA:15625574:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5d8a91f3a86b216d1ca564bae308b837 |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_11906; row=8923; data_type=In Vivo; mixture=Chemical; chemical_name=4-tert-Butylcyclohexanol; preferred_name=4-tert-Butylcyclohexanol; dtxsid=DTXSID5026623; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026623; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =4200 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_11907; row=8924; data_type=In Vivo; mixture=Chemical; chemical_name=4-tert-Butylcyclohexanol; preferred_name=4-tert-Butylcyclohexanol; dtxsid=DTXSID5026623; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026623; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=4192; RecordID=ARPathway2016_1800; DatasetName=ARPathway2016; DTXSID=DTXSID5026623; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026623 |
NTP ICE skin sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11500; Record_ID=skin_sensitization_invivo_2498; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5026623; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90141-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026623 |
| NTP ICE skin sensitization | Induction dose per skin area | 2592 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11498; Record_ID=skin_sensitization_invivo_2498; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5026623; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90141-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026623 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11504; Record_ID=skin_sensitization_invivo_2498; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5026623; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90141-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026623 |
ECHA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =300 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8fe4b0a7c65d1ce813; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13464/7/6/2?documentUUID=29f2fd75-a496-45d9-99e9-44563f27619a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837798_15844833_15850065_15850066:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b5c5c83cf5ea89d5e0c8e63464127594 |
| ECHA | NOAEL | =150 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8fe4b0a7c65d1ce81c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13464/7/6/2?documentUUID=341f03c9-2697-4a75-b830-b55fb7de2def; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837798_15844833_15850065_15850066:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b0525974ee01091e1ac1ab35a0aa695a |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =1.76 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630416_15630417:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_139c1a6ea540ee5bf2d46f39512bb671 |
| ToxValDB GESTIS DNEL | DNEL systemic | =4.93 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630416_15630417:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f3c95a870897f4ea19354666888d2edf |
ToxValDB HPVIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | NOAEL | =50 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | LONG_REF=Degussa AG (1999) Unpublished report. Report No. 98-0184-DGT.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: Jan. 30, 2007.; QUALITY=1; EXTERNAL_SOURCE_ID=62749; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639823_15639934:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8c29a1e858d3d81e2ebe7d2f1356b3e6 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | K0H1405S9C | UNII | - | - | - | mixture | - |