NOAEL Studies Cosmetic Ingredient

4,4'-Isopropylidenediphenol (Bisphenol A / BPA) NOAEL Studies

INCI: 4,4'-ISOPROPYLIDENEDIPHENOL

CAS: 80-05-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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California Proposition 65 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 MADL SQEdermal=3 ug/day - - 2015-05-11 Maximum allowable dose level -
California Proposition 65 California Proposition 65 listing ABdevelopmental listing type - - 2020-12-18 California Proposition 65 listing -
California Proposition 65 California Proposition 65 listing SQEfemale listing type - - 2015-05-11 California Proposition 65 listing -
EFSA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =5 mg/kg bw/day Mouse - - reproduction toxicity EFSA AFC - 2007 - OutputID 338 - organ weights - reproductive - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to 2,2-BIS(4-HYDROXYPHENYL)PROPANE (Bisphenol A) - doi:10.2903/j.efsa.2007.428
EFSA BMDL (10) =0.609 mg/kg bw/day Mouse oral - repeat dose other LONG_REF=EFSA CEF (2015). Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary. doi:10.2903/j.efsa.2015.3978.; TITLE=Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2015.3978; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=EFSA:15614270:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_faa0cd36bbbeb75b64401e873b31ded5
EFSA BMDL (10) =8.96 mg/kg bw/day Mouse oral - reproduction developmental LONG_REF=EFSA CEF (2015). Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary. doi:10.2903/j.efsa.2015.3978.; TITLE=Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2015.3978; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=organ weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=EFSA:15614269:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_804958193ba00feffaf655954dfd96be
EFSA NOAEL =5 mg/kg bw/day Mouse oral - reproduction developmental LONG_REF=EFSA AFC (2007). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to 2,2-BIS(4-HYDROXYPHENYL)PROPANE (Bisphenol A). doi:10.2903/j.efsa.2007.428.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to 2,2-BIS(4-HYDROXYPHENYL)PROPANE (Bisphenol A); AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2007.428; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=organ weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=EFSA:15614268:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3288eb82f1d45412d6849cdcf7ef41d6
Regulatory source 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source LOAEL =50 mg/kg/day - oral chronic IRIS chronic oral RfD system PoD row_hash=f0b5950887b7eab4; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=LOAEL : 5.0e1 mg/kg-day; system=Other; basis=Reduced mean body weight; point_of_departure=LOAEL : 5.0e1 mg/kg-day; composite_uf=1000; confidence=High; dtxsid=DTXSID7020182; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=356; rfd_last_updated=09/26/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0356_summary.pdf
Regulatory source RfD =0.05 mg/kg/day - oral chronic IRIS chronic oral RfD system row_hash=46d38f8758101a3d; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=5e-2; system=Other; basis=Reduced mean body weight; point_of_departure=LOAEL : 5.0e1 mg/kg-day; composite_uf=1000; confidence=High; dtxsid=DTXSID7020182; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=356; rfd_last_updated=09/26/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0356_summary.pdf
Regulatory source reproductive toxicity 1 - rat - developmental reproductive toxicity p.28
NTP ICE adme parameters 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 2.326 uL/min/10^6 cells Rat - - Measured; httk, Rat Hepatic Intrinsic Clearance sheet=Data; excel_row=2686; Record_ID=adme_parameters_1; Data_Type=Measured; DTXSID=DTXSID7020182; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=2.326; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Wetmore 2013; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE adme parameters Clint 19.9 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2688; Record_ID=adme_parameters_1; Data_Type=Measured; DTXSID=DTXSID7020182; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=19.9; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE adme parameters Fu 0.0385 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2689; Record_ID=adme_parameters_1; Data_Type=Measured; DTXSID=DTXSID7020182; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0385; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE adme parameters Fu 0.7181 fraction Rat - - Measured; httk, Rat Plasma Fraction Unbound sheet=Data; excel_row=2687; Record_ID=adme_parameters_1; Data_Type=Measured; DTXSID=DTXSID7020182; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.7181; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Wetmore 2013; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE cancer 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer Top dose 2000 ppm Rat Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=7374; Record_ID=cancer_4225; Data_Type=In Vivo; Formulation_Name=Bisphenol A; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Reference=TR-215; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr215/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE cancer Top dose 5000 ppm Mouse Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=7381; Record_ID=cancer_4222; Data_Type=In Vivo; Formulation_Name=Bisphenol A; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=5000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed feed; Reference=TR-215; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr215/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE cancer Top dose 10000 ppm Mouse Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=7372; Record_ID=cancer_4224; Data_Type=In Vivo; Formulation_Name=Bisphenol A; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=10000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Dosed feed; Reference=TR-215; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr215/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine 104 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine AC50 0.669617515126504 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=5646; RecordID=ERPathway2016_161; DatasetName=ERPathway2016; DTXSID=DTXSID7020182; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=0.669617515126504; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50 16.8348356403529 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=5640; RecordID=ARPathway2016_286; DatasetName=ARPathway2016; DTXSID=DTXSID7020182; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=16.8348356403529; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 0.1585 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13115; Record_ID=endocrine_invitro_2690; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.15848931899999999; Reported_Response_Unit=nM; Response=0.1585; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 80 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13318; Record_ID=endocrine_invitro_1469; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=80; Reported_Response_Unit=nM; Response=80; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lee et al. 2003; 12805653; 10.1093/toxsci/kfg150; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 158.489 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13257; Record_ID=endocrine_invitro_2761; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=158.489; Reported_Response_Unit=nM; Response=158.489; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 318 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13317; Record_ID=endocrine_invitro_1471; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=318; Reported_Response_Unit=nM; Response=318; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lee et al. 2003; 12805653; 10.1093/toxsci/kfg150; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 746 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13253; Record_ID=endocrine_invitro_1732; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=746; Reported_Response_Unit=nM; Response=746; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Xu et al. 2005; 16169144; 10.1016/j.tox.2005.08.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 920 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13509; Record_ID=endocrine_invitro_2651; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=920; Reported_Response_Unit=nM; Response=920; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Molina-Molina et al. 2013; 23714657; 10.1016/j.taap.2013.05.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 1800 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13277; Record_ID=endocrine_invitro_1461; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=1.8; Reported_Response_Unit=uM; Conversion_Factor=1000; Conversion_Factor_Value=1000; Converted_Response=1800; Converted_Response_Unit=nM; Response=1800; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lee et al. 2003; 12805653; 10.1093/toxsci/kfg150; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 2340 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13240; Record_ID=endocrine_invitro_2599; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=2340; Reported_Response_Unit=nM; Response=2340; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Teng et al. 2013; 23562765; 10.1016/j.cbi.2013.03.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 2500 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13238; Record_ID=endocrine_invitro_2829; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=2500; Reported_Response_Unit=nM; Response=2500; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 2800 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13248; Record_ID=endocrine_invitro_1494; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=2800; Reported_Response_Unit=nM; Response=2800; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Willemsen et al. 2004; 14513195; 10.1007/s00216-003-2217-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 3200 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13242; Record_ID=endocrine_invitro_2002; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=3200; Reported_Response_Unit=nM; Response=3200; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Krüger et al. 2008; 18294747; 10.1016/j.tox.2007.12.028; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 4200 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13281; Record_ID=endocrine_invitro_2253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=4200; Reported_Response_Unit=nM; Response=4200; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 4300 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13519; Record_ID=endocrine_invitro_1669; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=4300; Reported_Response_Unit=nM; Response=4300; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kitamura et al. 2005; 15635150; 10.1093/toxsci/kfi074; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 5000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13517; Record_ID=endocrine_invitro_1685; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=5000; Reported_Response_Unit=nM; Response=5000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Michelini et al. 2005; 15797324; 10.1016/j.bios.2004.10.018; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 5250 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13511; Record_ID=endocrine_invitro_1885; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=5250; Reported_Response_Unit=nM; Response=5250; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Tamura et al. 2006; 16876421; 10.1016/j.bmc.2006.06.064; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 5700 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13493; Record_ID=endocrine_invitro_1889; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=5700; Reported_Response_Unit=nM; Response=5700; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Tamura et al. 2006; 16876421; 10.1016/j.bmc.2006.06.064; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 7000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13515; Record_ID=endocrine_invitro_3097; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=7000; Reported_Response_Unit=nM; Response=7000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Paris et al. 2002; 12161000; 10.1016/s0303-7207(02)00094-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 7900 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=165; Record_ID=endocrine_invitro_159; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=7900; Reported_Response_Unit=nM; Response=7900; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 11800 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13244; Record_ID=endocrine_invitro_2535; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=11800; Reported_Response_Unit=nM; Response=11800; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Rostkowski et al. 2011; 22047186; 10.1021/es202966c; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 19600 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13520; Record_ID=endocrine_invitro_1571; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=19600; Reported_Response_Unit=nM; Response=19600; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 39000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13513; Record_ID=endocrine_invitro_2936; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=39000; Reported_Response_Unit=nM; Response=39000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Roelofs et al. 2015; 25576683; 10.1016/j.tox.2015.01.003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 55380 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8329; Record_ID=endocrine_invitro_2650; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=55380; Reported_Response_Unit=nM; Response=55380; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Molina-Molina et al. 2013; 23714657; 10.1016/j.taap.2013.05.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 62700 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=517; Record_ID=endocrine_invitro_511; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=62700; Reported_Response_Unit=nM; Response=62700; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Oehlmann et al. 2006; 16818258; 10.1289/ehp.8065; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 75000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=169; Record_ID=endocrine_invitro_163; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=75000; Reported_Response_Unit=nM; Response=75000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 110000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=167; Record_ID=endocrine_invitro_161; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=110000; Reported_Response_Unit=nM; Response=110000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kim et al. 2010; 20371976; 10.2131/jts.35.239; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine AC50/EC50/IC50 1000001453 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13104; Record_ID=endocrine_invitro_2593; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=1000001453; Reported_Response_Unit=nM; Response=1000001453; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine ACC 0.228354371372336 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=5647; RecordID=ERPathway2016_161; DatasetName=ERPathway2016; DTXSID=DTXSID7020182; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=0.228354371372336; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine ACC 17.0951719331564 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=5641; RecordID=ARPathway2016_286; DatasetName=ARPathway2016; DTXSID=DTXSID7020182; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=17.0951719331564; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine EC50 533 nM - - - In Vitro; ER Transactivation-Agonist (VM7Luc Assay) sheet=Data_invitro; excel_row=16595; Record_ID=endocrine_invitro_4468; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=ER Transactivation-Agonist (VM7Luc Assay); Endpoint=EC50; Reported_Response=5.3300000000000002E-7; Reported_Response_Unit=M; Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=533; Converted_Response_Unit=nM; Response=533; Response_Unit=nM; Reference=|OECD TG 455; https://www.oecd.org/env/test-no-455-performance-based-test-guideline-for-stably-transfected-transactivation-in-vitro-assays-to-detect-estrogen-receptor-9789264265295-en.htm; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine IC01 408 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13015; Record_ID=endocrine_invitro_2679; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=IC01; Reported_Response=408; Reported_Response_Unit=IC01 (nM); Response=408; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine IC20 <10000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13026; Record_ID=endocrine_invitro_2900; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=IC20; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=10000; Reported_Response_Unit=IC20 (nM); Response=10000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine IC25 <1000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13067; Record_ID=endocrine_invitro_2029; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=IC25; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=1000; Reported_Response_Unit=IC25 (nM); Response=1000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bonefeld-Jørgensen et al. 2007; 18174953; 10.1289/ehp.9368; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine IC50 1500 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13279; Record_ID=endocrine_invitro_2958; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=IC50; Reported_Response=1.5E-6; Reported_Response_Unit=IC50 (M); Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=1500; Converted_Response_Unit=nM; Response=1500; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lee et al. 2003; 12805653; 10.1093/toxsci/kfg150; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine IC50 3350 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13390; Record_ID=endocrine_invitro_2735; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=IC50; Reported_Response=3.35; Reported_Response_Unit=IC50 (uM); Conversion_Factor=1000; Conversion_Factor_Value=1000; Converted_Response=3350; Converted_Response_Unit=nM; Response=3350; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fic et al. 2014; 25048928; 10.1016/j.chemosphere.2014.04.080; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine IC50 81000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13392; Record_ID=endocrine_invitro_2964; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=IC50; Reported_Response=8.1000000000000004E-5; Reported_Response_Unit=IC50 (M); Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=81000; Converted_Response_Unit=nM; Response=81000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Ki 18000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1865; Record_ID=endocrine_invitro_1098; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=Ki; Reported_Response=18000; Reported_Response_Unit=nM; Response=18000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lee et al. 2003; 12805653; 10.1093/toxsci/kfg150; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LEL 0.1 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14955; Record_ID=endocrine_invitro_1573; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=0.1; Reported_Response_Unit=nM; Response=0.1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Stroheker et al. 2004; 15110097; 10.1016/j.fct.2004.01.012; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LEL 1 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10778; Record_ID=endocrine_invitro_2917; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=1; Reported_Response_Unit=nM; Response=1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LEL 10 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=15118; Record_ID=endocrine_invitro_2347; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=10; Reported_Response_Unit=nM; Response=10; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Christen et al. 2010; 20943248; 10.1016/j.chemosphere.2010.09.031; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LEL 100 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14953; Record_ID=endocrine_invitro_1732; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=100; Reported_Response_Unit=nM; Response=100; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Xu et al. 2005; 16169144; 10.1016/j.tox.2005.08.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LEL 199.5 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14957; Record_ID=endocrine_invitro_2651; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=199.52600000000001; Reported_Response_Unit=nM; Response=199.5; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Molina-Molina et al. 2013; 23714657; 10.1016/j.taap.2013.05.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LEL 600 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14961; Record_ID=endocrine_invitro_1988; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=600; Reported_Response_Unit=nM; Response=600; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bonefeld-Jørgensen et al. 2007; 18174953; 10.1289/ehp.9368; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LEL 1584.89 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14949; Record_ID=endocrine_invitro_1273; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=1584.89; Reported_Response_Unit=nM; Response=1584.89; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LEL 2000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14963; Record_ID=endocrine_invitro_2250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=2000; Reported_Response_Unit=nM; Response=2000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ermler et al. 2010; 20488240; 10.1016/j.tiv.2010.05.007; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LEL 3000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14951; Record_ID=endocrine_invitro_3097; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=3000; Reported_Response_Unit=nM; Response=3000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Paris et al. 2002; 12161000; 10.1016/s0303-7207(02)00094-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LEL 4380 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14970; Record_ID=endocrine_invitro_2583; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=1000000; Reported_Response_Unit=ng/L; Conversion_Factor=Molecular Weight; Conversion_Factor_Value=228.291; Conversion_Factor_Source=EPA Dashboard; Converted_Response=4380.3741715617352; Converted_Response_Unit=nM; Response=4380; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LEL 10000 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10556; Record_ID=endocrine_invitro_2650; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=10000; Reported_Response_Unit=nM; Response=10000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Molina-Molina et al. 2013; 23714657; 10.1016/j.taap.2013.05.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 2 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1014; Record_ID=endocrine_invivo_361; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=2; Response_Unit=mg/kg/day; Species=Rat; Sex=Female; Route=Subcutaneous; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Takeyoshi 2006; Not available; https://www.oecd.org/env/ehs/testing/37504278.pdf|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 10 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1016; Record_ID=endocrine_invivo_456; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=10; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Hsd:SD; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 20 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 20 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1011; Record_ID=endocrine_invivo_358; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=20; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crj:CD(SD); Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Yamasaki et al. 2002; 11750080; 10.1016/s0300-483x(01)00505-4|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 30 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1022; Record_ID=endocrine_invivo_375; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=30; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=300; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 3; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 50 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 84; Age_Ovariectomized_or_Castrated=8 Weeks; Time_Elapsed_Between_Surgery_and_Treatment=4 weeks; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=988; Record_ID=endocrine_invivo_455; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=50; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Jcl:Sprague-Dawley; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=100; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Takemura et al. 2005; 15596252; 10.1016/j.tox.2004.09.015|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 75 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1018; Record_ID=endocrine_invivo_369; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=75; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=75; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 6; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 100 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=999; Record_ID=endocrine_invivo_349; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=600; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 200 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1013; Record_ID=endocrine_invivo_360; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=200; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=SD; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Ohno et al. 2003; 12453737; 10.1016/s0278-6915(02)00211-9|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 300 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1004; Record_ID=endocrine_invivo_342; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=300; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Wistar (Hsd/Cpb:WU); Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 375 mg/kg bw/day Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1009; Record_ID=endocrine_invivo_356; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=375; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=600; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 400 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 to 3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1015; Record_ID=endocrine_invivo_364; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=400; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=600; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Diethylstilbestrol; Reference=Ashby and Tonwell 1998; 9799186; 10.1289/ehp.98106719|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 600 mg/kg bw/day Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1010; Record_ID=endocrine_invivo_357; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=600; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 800 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 21 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=7 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1005; Record_ID=endocrine_invivo_354; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=800; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Alpk:APfSD; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Matthews et al. 2001; 11258963; 10.1021/tx0001833|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine LOEL 1000 mg/kg bw/day Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1019; Record_ID=endocrine_invivo_368; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=1000; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=SPF-bred Wistar, HSD/Cpb:WU; Strain=Wistar; Sex=Female; Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=5643; RecordID=ARPathway2016_286; DatasetName=ARPathway2016; DTXSID=DTXSID7020182; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Model Score 0.345 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=5642; RecordID=ARPathway2016_286; DatasetName=ARPathway2016; DTXSID=DTXSID7020182; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.345; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Model Score 0.45 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=5648; RecordID=ERPathway2016_161; DatasetName=ERPathway2016; DTXSID=DTXSID7020182; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.45; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine NOEL 600 mg/kg bw/day Rat Oral Treatment_Duration=10 days; Age_at_First_Dose=PND 56; Age_Ovariectomized_or_Castrated=PND 42; Time_Elapsed_Between_Surgery_and_Treatment=14 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 36 hours; Number_of_Doses_Tested=6 In Vivo; Hershberger-Agonist sheet=Data_invivo; excel_row=2189; Record_ID=endocrine_invivo_941; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Hershberger-Agonist; Endpoint=NOEL; Response=600; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Sprague-Dawley; Strain=Sprague-Dawley; Sex=Male (castrated); Route=Oral; Reference_Hormone=Testosterone propionate; Reference_Hormone_Dose=0.2; Reference_Hormone_Dose_Units=mg/kg/day; Reference_Hormone_Route=Subcutaneous; Additional_Information=Browne et al. 2018 unique record identifier 264; Reference=Yamasaki et al. 2003; 12504345; 10.1016/s0300-483x(02)00445-6|Browne et al. 2018; 30205136; 10.1016/j.reprotox.2018.08.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine PC50 294 nM - - - In Vitro; ER Transactivation-Agonist (STTA Assay) sheet=Data_invitro; excel_row=16542; Record_ID=endocrine_invitro_4468; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=ER Transactivation-Agonist (STTA Assay); Endpoint=PC50; Reported_Response=2.9400000000000001E-7; Reported_Response_Unit=M; Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=294; Converted_Response_Unit=nM; Response=294; Response_Unit=nM; Reference=|OECD TG 455; https://www.oecd.org/env/test-no-455-performance-based-test-guideline-for-stably-transfected-transactivation-in-vitro-assays-to-detect-estrogen-receptor-9789264265295-en.htm; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine RBA 0.004074 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1967; Record_ID=endocrine_invitro_163; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=RBA; Reported_Response=-2.39; Reported_Response_Unit=Unitless; Conversion_Factor=Anti-log; Converted_Response=4.0738027780411225E-3; Converted_Response_Unit=Unitless; Response=0.004074; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine RBA 0.0041 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2443; Record_ID=endocrine_invitro_163; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=RBA; Reported_Response=4.1000000000000003E-3; Reported_Response_Unit=Unitless; Response=0.0041; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine RBA 0.016 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2445; Record_ID=endocrine_invitro_161; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=RBA; Reported_Response=1.6E-2; Reported_Response_Unit=Unitless; Response=1.6E-2; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kim et al. 2010; 20371976; 10.2131/jts.35.239; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine RBA 0.0301 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2442; Record_ID=endocrine_invitro_1102; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=RBA; Reported_Response=3.0099999999999998E-2; Reported_Response_Unit=Unitless; Response=0.0301; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Liu et al. 2009; 19862954; 10.1016/s1001-0742(08)62356-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine RBA 0.215 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2444; Record_ID=endocrine_invitro_164; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.215; Reported_Response_Unit=Unitless; Response=0.215; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine RIC20 1200 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13348; Record_ID=endocrine_invitro_3069; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=RIC20; Reported_Response=1200; Reported_Response_Unit=RIC20 (nM); Response=1200; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Relative potency 45 % - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=15206; Record_ID=endocrine_invitro_2741; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=AR Transactivation-Antagonist; Endpoint=Relative potency; Reported_Response=45; Reported_Response_Unit=%; Response=45; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ermler et al. 2010; 20488240; 10.1016/j.tiv.2010.05.007; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 120 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=709; Record_ID=endocrine_invivo_361; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=120; Response_Unit=%; Species=Rat; Sex=Female; Route=Subcutaneous; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Takeyoshi 2006; Not available; https://www.oecd.org/env/ehs/testing/37504278.pdf|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 124.1 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 21 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=8 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=711; Record_ID=endocrine_invivo_345; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=124.1; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:APfSD; Strain=Alderley Park; Sex=Female; Route=Oral; Maximum_Dose=800.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 126 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=706; Record_ID=endocrine_invivo_341; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=126; Response_Unit=%; Species=Rat; Reported_Strain=SPF/VAF Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 128 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=708; Record_ID=endocrine_invivo_344; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=128; Response_Unit=%; Species=Rat; Reported_Strain=SD; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 130 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=720; Record_ID=endocrine_invivo_382; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=130; Response_Unit=%; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=75; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 4; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 131 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=690; Record_ID=endocrine_invivo_357; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=131; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 131.4 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 to 3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=721; Record_ID=endocrine_invivo_348; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=131.4; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female; Route=Oral; Maximum_Dose=600.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Diethylstilbestrol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 136 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=703; Record_ID=endocrine_invivo_356; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=136; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=600; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 137 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=687; Record_ID=endocrine_invivo_342; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=137; Response_Unit=%; Species=Rat; Reported_Strain=Wistar (Hsd/Cpb:WU); Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 140 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=4 or 24 hours; Number_of_Doses_Tested=8 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=714; Record_ID=endocrine_invivo_346; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=140; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:APfSD (Wistar derived); Strain=Alderley Park; Sex=Female; Route=Oral; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Ashby and Odum 2004; 15456929; 10.1093/toxsci/kfh283|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 141 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 20 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=705; Record_ID=endocrine_invivo_358; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=141; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD); Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Yamasaki et al. 2002; 11750080; 10.1016/s0300-483x(01)00505-4|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 143 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=702; Record_ID=endocrine_invivo_377; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=143; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)BR; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 147 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=701; Record_ID=endocrine_invivo_355; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=147; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:ApfSD; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 149.5 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 to 3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=691; Record_ID=endocrine_invivo_364; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=149.5; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=600.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Diethylstilbestrol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 150 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=704; Record_ID=endocrine_invivo_378; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=150; Response_Unit=%; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=75; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 5; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 157 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=693; Record_ID=endocrine_invivo_368; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=157; Response_Unit=%; Species=Rat; Reported_Strain=SPF-bred Wistar, HSD/Cpb:WU; Strain=Wistar; Sex=Female; Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol A; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 160 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=695; Record_ID=endocrine_invivo_370; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=160; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:ApfSD; Strain=Alderley Park; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 167 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=727; Record_ID=endocrine_invivo_350; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=167; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 172 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=688; Record_ID=endocrine_invivo_353; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=172; Response_Unit=%; Species=Rat; Reported_Strain=SPF-bred Wistar, HSD/Cpb:WU; Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 175 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=1008; Record_ID=endocrine_invivo_456; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=175; Response_Unit=%; Species=Rat; Reported_Strain=Hsd:SD; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 189 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=692; Record_ID=endocrine_invivo_366; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=189; Response_Unit=%; Species=Rat; Reported_Strain=SPF/VAF Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 190 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=718; Record_ID=endocrine_invivo_379; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=190; Response_Unit=%; Species=Rat; Reported_Strain=Ap; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=600; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Experiment 1; Reference=Tinwell and Ashby 2004; 15064164; 10.1289/ehp.6831|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 203 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=724; Record_ID=endocrine_invivo_349; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=203; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=600.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 205 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 84; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=699; Record_ID=endocrine_invivo_373; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=205; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=600.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol C; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 216.7 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 21 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=7 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=737; Record_ID=endocrine_invivo_354; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=216.7; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:APfSD; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=800.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 230 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=707; Record_ID=endocrine_invivo_360; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=230; Response_Unit=%; Species=Rat; Reported_Strain=SD; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Ohno et al. 2003; 12453737; 10.1016/s0278-6915(02)00211-9|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 235 % Rat Subcutaneous Treatment_Duration=7 days; Age_at_First_Dose=PND 56 to 86; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=719; Record_ID=endocrine_invivo_380; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=235; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol D; Reference=Kanno et al. 2003; 12948896; 10.1289/ehp.5780|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 251 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=700; Record_ID=endocrine_invivo_374; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=251; Response_Unit=%; Species=Rat; Reported_Strain=Crl:CD(SD)IGS BR; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=600.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol B; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
NTP ICE endocrine Uterine weight increase vs control 253 % Rat Subcutaneous Treatment_Duration=7 days; Age_at_First_Dose=PND 56 to 85; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=14 to 28 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3+ In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=697; Record_ID=endocrine_invivo_371; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7020182; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=253; Response_Unit=%; Species=Rat; Reported_Strain=SPF/VAF Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=800.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Additional_Information=Protocol D; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7020182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7020182
SCCS Opinion 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =1 - rat - developmental reproductive toxicity p.28
EPA ToxRefDB v3 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EPA ToxRefDB v3 LEL =160 mg/kg bw/day rat oral 6 GD to 15 GD DEV study_id=2612; toxval_study_source_id=studyid2612_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-lethargy|in life observation-clinical signs-pica|in life observation-body weight-body weight gain|in life observation-body weight-body weight|in life observation-clinical signs-piloerection|in life observation-clinical signs-fur (altered appearance); dose_level=1; study_year=1985; study_citation=NTP (1985) Teratologic evaluation of bisphenol A administered to CD rats on gestation days 6 through 15. NTP-85-089; dsstox_substance_id=DTXSID7020182; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL >1280 mg/kg bw/day rat oral 6 GD to 15 GD DEV study_id=2612; toxval_study_source_id=studyid2612_Fetal_Fetal_MF_NA; dose_level=4; study_year=1985; study_citation=NTP (1985) Teratologic evaluation of bisphenol A administered to CD rats on gestation days 6 through 15. NTP-85-089; dsstox_substance_id=DTXSID7020182; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL >0 mg/kg bw/day rat oral 6 GD to 15 GD DEV study_id=2612; toxval_study_source_id=studyid2612_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-fur (altered appearance)|in life observation-clinical signs-lethargy|in life observation-body weight-body weight|in life observation-body weight-body weight gain|in life observation-clinical signs-pica|in life observation-clinical signs-piloerection; dose_level=0; study_year=1985; study_citation=NTP (1985) Teratologic evaluation of bisphenol A administered to CD rats on gestation days 6 through 15. NTP-85-089; dsstox_substance_id=DTXSID7020182; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ECHA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =50 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba1a2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/15752?documentUUID=da4fb77b-5b73-45c1-b64b-4bf313fcd139; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=P0: mortality|P0: clinical biochemistry|P0: organ weights and organ / body weight ratios|P0: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15855714:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_10a19969dded60327d5a3bd4af491b30
ECHA NOAEL =150 mg/kg bw/day Rat oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac7ae4b0a7c65d1bf424; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/15752?documentUUID=da4fb77b-5b73-45c1-b64b-4bf313fcd139; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15820640:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8250748fb280e8d354d8dfac89482fc6
ToxValDB ECOTOX 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =125 mg/kg bw/day Rat injection short-term; 21 days developmental LONG_REF=Scand. J. Work Environ. Health7(Suppl. 4): 66-75 Hardin,B.D., G.P. Bond, M.R. Sikov, F.D. Andrew, R.P. Beliles, and R.W. Niemeier Testing of Selected Workplace Chemicals for Teratogenic Potential 1981; TITLE=Testing of Selected Workplace Chemicals for Teratogenic Potential; AUTHOR=Hardin,B.D., G.P. Bond, M.R. Sikov, F.D. Andrew, R.P. Beliles, and R.W. Niemeier; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=49968; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Development: Abnormal|Development: Slowed, Retarded, Delayed or Non-development|Multiple: Multiple effects reported as one result|Reproduction: Number of implantations|Reproduction: Pregnant, Paris or Gravid; TOXICOLOGICAL_EFFECT_CATEGORY=development|multiple|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594947_15594948_15594949_15599008:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d6d7989cd273b74361a08e4d1c503d07
ToxValDB ECOTOX LOEL =200 mg/kg bw/day Rat oral short-term; 14 days short-term LONG_REF=Reprod. Toxicol.33(3): 339-352 Quignot,N., M. Arnaud, F. Robidel, A. Lecomte, M. Tournier, C. Cren-Olive, R. Barouki, and E. Lemazurier Characterization of Endocrine-Disrupting Chemicals Based on Hormonal Balance Disruption in Male and Female Adult Rats 2012; TITLE=Characterization of Endocrine-Disrupting Chemicals Based on Hormonal Balance Disruption in Male and Female Adult Rats; AUTHOR=Quignot,N., M. Arnaud, F. Robidel, A. Lecomte, M. Tournier, C. Cren-Olive, R. Barouki, and E. Lemazurier; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=165355; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight|Reproduction: Velocity; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|reproduction; STUDY_GROUP=ECOTOX:15611650:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=4a332d01caf928acb3a7e575deede9db
ToxValDB ECOTOX NOEL =0.1 mg Rat injection short-term; 13 days reproduction developmental LONG_REF=Endocrinology143(12): 4797-4808 Rivas,A., J.S. Fisher, C. McKinnell, N. Atanassova, and R.M. Sharpe Induction of Reproductive Tract Developmental Abnormalities in the Male Rat by Lowering Androgen Production or Action in Combination with a Low Dose of Diethylstilbestrol: Evidence for Importance of the Androgen-Estrog 2002; TITLE=Induction of Reproductive Tract Developmental Abnormalities in the Male Rat by Lowering Androgen Production or Action in Combination with a Low Dose of Diethylstilbestrol: Evidence for Importance of the Androgen-Estrog; AUTHOR=Rivas,A., J.S. Fisher, C. McKinnell, N. Atanassova, and R.M. Sharpe; DOI=10.1210/en.2002-220531; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=108224; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Cell(s): Height|Hormone(s): Testosterone|Morphology: Area; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|gross pathology|other; STUDY_GROUP=ECOTOX:15594316:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5af1f0da7c6a8f5e1e58be7ab0fb72da
ToxValDB ECOTOX NOEL =0.5 mg Rat injection subchronic; 89 days reproduction developmental LONG_REF=Int. J. Androl.26(1): 26-36 Sharpe,R.M., A. Rivas, M. Walker, C. McKinnell, and J.S. Fisher Effect of Neonatal Treatment of Rats with Potent or Weak (Environmental) Oestrogens, or with a GnRH Antagonist, on Leydig Cell Development and Function Through Puberty into Adulthood 2003; TITLE=Effect of Neonatal Treatment of Rats with Potent or Weak (Environmental) Oestrogens, or with a GnRH Antagonist, on Leydig Cell Development and Function Through Puberty into Adulthood; AUTHOR=Sharpe,R.M., A. Rivas, M. Walker, C. McKinnell, and J.S. Fisher; DOI=10.1046/j.1365-2605.2003.00385.x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=108194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Cell(s): Volume|Hormone(s): Testosterone; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595249_15600635:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=79fa2e17343cd549c4855029f03ff8f3
ToxValDB ECOTOX NOEL =1 % Mouse oral chronic; 294 days chronic LONG_REF=Fundam. Appl. Toxicol.39(1): 1-10 Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays 1997; TITLE=Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays; AUTHOR=Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel; DOI=10.1006/faat.1997.2338; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=151647; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Reproduction: Number of ovarian follicles; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15598021:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=466e5a74dbf51817f9939587fe74fb60
ToxValDB ECOTOX NOEL =85 mg/kg bw/day Rat injection short-term; 21 days developmental LONG_REF=Scand. J. Work Environ. Health7(Suppl. 4): 66-75 Hardin,B.D., G.P. Bond, M.R. Sikov, F.D. Andrew, R.P. Beliles, and R.W. Niemeier Testing of Selected Workplace Chemicals for Teratogenic Potential 1981; TITLE=Testing of Selected Workplace Chemicals for Teratogenic Potential; AUTHOR=Hardin,B.D., G.P. Bond, M.R. Sikov, F.D. Andrew, R.P. Beliles, and R.W. Niemeier; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=49968; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Development: Abnormal|Development: Slowed, Retarded, Delayed or Non-development|Reproduction: Number of implantations|Reproduction: Pregnant, Paris or Gravid; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594947_15594948_15594949_15599008:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=db8239956e23e08f389c4551da559a42
ToxValDB EPA TSCA 8e 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB EPA TSCA 8e LEL =1 mg/L Rat oral subchronic (developmental); 9 weeks reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88960000061_80057_73FC987A7C1F773885256E6F0050C7D1.pdf; TOXICOLOGICAL_EFFECT=F1: reduced testicular size; STUDY_GROUP=EPA TSCA 8e:15956970:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c83b6f1a87cdb6c03535947f848099aa
ToxValDB EPA TSCA 8e LEL =20 ng/g bw Mouse oral - repeat dose other STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=09022526801189f9_8EHQ-02-15079_11-30-2012_8EF_PHCS_Support - 89120000553.pdf; TOXICOLOGICAL_EFFECT=increased incidence of defects in alignment of chromosomes in oocytes; STUDY_GROUP=EPA TSCA 8e:15956969:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_abe82dfa6c95b2da6cf19592b69c2f6a
ToxValDB EU SCOEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB EU SCOEL NOAEC =10 mg/m3 Rat inhalation subchronic; 13 weeks subchronic LONG_REF=Nitschke KD, Lomax LG, Schuetz DJ, Hopkins PJ, Weiss SW (1988). Bisphenol-A: 13 week aerosol toxicity study with Fischer 344 rats. Dow Chemical Company, unpublished report.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985b9e4b02565fc7d35af; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/089_4-4-isopropylidenediphenol_oel_en.pdf; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=mild olfactory epithelium inflammation; STUDY_GROUP=EU SCOEL:15952296:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ab0b91c630fbcdd477b2e262ed05cab7
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =2 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632893_15632894:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5e6e5515b4bdc735cc4b2657a5634f50
ToxValDB HAWC Project 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HAWC Project LOEL =20 mg/kg bw/day Rat injection short-term; 3 days short-term LONG_REF=Yamasaki K, Takeyoshi M, Yakabe Y, Sawaki M, Imatanaka N, Takatsuki M. 2002. Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals. Toxicology 170:21-30.; TITLE=Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals.; AUTHOR=Yamasaki K, Takeyoshi M, Yakabe Y, Sawaki M, Imatanaka N, Takatsuki M; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/46/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/21085/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=uterus: uterine dry weight (absolute); TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=HAWC Project_dup_-_15636115_15636545:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d21af4292c60d8a5e73bc82ff4b76458
ToxValDB HAWC Project NOEL =2 mg/kg bw/day Rat injection short-term; 3 days short-term LONG_REF=Yamasaki K, Takeyoshi M, Yakabe Y, Sawaki M, Imatanaka N, Takatsuki M. 2002. Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals. Toxicology 170:21-30.; TITLE=Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals.; AUTHOR=Yamasaki K, Takeyoshi M, Yakabe Y, Sawaki M, Imatanaka N, Takatsuki M; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/46/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/21085/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=uterus: uterine dry weight (absolute); TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=HAWC Project_dup_-_15636115_15636545:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_935aedd5eda0751a982b12a41d707404
ToxValDB HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOEL =40 mg/kg bw/day Rat oral - subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0defe4b0a676289de8c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Deaths|Clinical Observation: Loose stool Locomotor activity decrease, Hypopnea Subnormal temperature decrease|Body Weight Changes: decrease|Food Consumption: decrease|Hematology: PT increase, Hgb decrease, Hct decrease|Blood Chemistry: GOT increase, , Che decrease, TG decrease, Alp increase, gamma-GTP increase, Alb decrease|Relative Organ Weight: Heart decrease, Testis increase, prostate gland decrease, adrenal increase, Thyroid increase, liver increase|Histopathology: Duodenum-Lacteal dilatation Cecum-Mucosal hyperplasia Colon-Mucosal hyperplasia Liver-Prominent nucleoli hepatocytes Kidney-Tubular degeneration/necrosis Forestomach-Squamous epithelial cell hyperplasia Jejunum-Lacteal dilatation Adrenal-Cortical vacuolization; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=HESS:15638416:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0b3a7ca898558970c6ef35a74281f9b7
ToxValDB HPVIS 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HPVIS LOAEL =1000 ppm Rat oral chronic; 103 weeks reproduction developmental LONG_REF=Integrated Risk Information System (IRIS Document); Bisphenol A. CASRN: 80-05-7. 1993.Data entered into the HPVIS extracted from the robust summary document posted to the HPV Challenge Program website Mar. 30, 2007.; QUALITY=2; EXTERNAL_SOURCE_ID=63322; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=HPVIS:15639393:-:F0parental; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_afe84fa9a5c8826c67b71631c05fe872
ToxValDB HPVIS NOAEL =75 ppm Rat oral subchronic; 13 weeks reproduction developmental LONG_REF=R.W. Tyl, Ph.D., DABT, C.B. Myers, M.S, M.C. Marr, B.A., LATG. 2000. Three-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD Sprague-Dawley Rats. RTI Report #: 65C-07036000.Data entered into the HPVIS extracted from the robust summary document posted to the HPV Challenge Program website Mar. 30, 2007.; QUALITY=1; EXTERNAL_SOURCE_ID=65504; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15643256:-:F0parental; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_efc9f4811eb0026b60d3944fcfdab89c
ToxValDB HPVIS NOAEL >640 mg/kg bw/day Rat oral short-term; 10 days developmental LONG_REF=Morrissey, R.E., George, J.D., Price, C.J., Tyl, R.W., Marr, M.C. and Kimmel, C.A. 1987. The developmental toxicity of bisphenol A in rats and mice. Fundam. Appl. Toxicol. 8:571-582. As cited in the EU Risk Assessment.Data entered into the HPVIS extracted from the robust summary document posted to the HPV Challenge Program website Mar. 30, 2007.; QUALITY=1; EXTERNAL_SOURCE_ID=58035; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15642325:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_29f8d03a0ed491abf3a8caad1f6f8143
ToxValDB HPVIS NOAEL =750 ppm Rat oral subchronic; 13 weeks reproduction developmental LONG_REF=R.W. Tyl, Ph.D., DABT, C.B. Myers, M.S, M.C. Marr, B.A., LATG. 2000. Three-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD Sprague-Dawley Rats. RTI Report #: 65C-07036000.Data entered into the HPVIS extracted from the robust summary document posted to the HPV Challenge Program website Mar. 30, 2007.; QUALITY=1; EXTERNAL_SOURCE_ID=65503; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15643255:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc6421dcc0ff027b6ccd28539ea01a3b
ToxValDB IRIS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB IRIS LOAEL =50 mg/kg bw/day Rat oral chronic; 103 weeks chronic LONG_REF=NTP (National Toxicology Program). 1982. NTP Technical report on the carcinogenesis bioassay of bisphenol A (CAS No. 80-05-7) in F344 rats and B6C3F1 mice (feed study). NTP?80-35. NIH Publ. No. 82-1770; TITLE=NTP Technical report on the carcinogenesis bioassay of bisphenol A (CAS No. 80-05-7) in F344 rats and B6C3F1 mice (feed study); AUTHOR=NTP (National Toxicology Program); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a57a6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=356; TOXICOLOGICAL_EFFECT=reduced mean body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=IRIS:15645483:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_034754046264971441bb237e2acd394a
ToxValDB IRIS RfD =0.05 mg/kg bw/day Human oral - Toxicity Value LONG_REF=NTP (National Toxicology Program). 1982. NTP Technical report on the carcinogenesis bioassay of bisphenol A (CAS No. 80-05-7) in F344 rats and B6C3F1 mice (feed study). NTP?80-35. NIH Publ. No. 82-1771; TITLE=NTP Technical report on the carcinogenesis bioassay of bisphenol A (CAS No. 80-05-7) in F344 rats and B6C3F1 mice (feed study); AUTHOR=NTP (National Toxicology Program); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a57a6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=356; TOXICOLOGICAL_EFFECT=Reduced mean body weight in male/female rats; STUDY_GROUP=IRIS:15644445:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1ed53a09770a8e2b09237a62217a5cca
ToxValDB RSL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB RSL RfD =0.6 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663206:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cf7f50a6c967c543e7ac6dfed1d6f7fe
ToxValDB ToxRefDB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ToxRefDB LEL =160 mg/kg bw/day Rat oral short-term (developmental); 10 days reproduction developmental LONG_REF=NTP (1985) Teratologic evaluation of bisphenol A administered to CDAR rats on gestation days 6 through 15. NTP-85-089; TITLE=Teratologic evaluation of bisphenol A administered to CDAR rats on gestation days 6 through 15; AUTHOR=NTP; EXTERNAL_SOURCE_ID=2612; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-pica|systemic: in life observation-clinical signs-lethargy|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-piloerection|systemic: in life observation-clinical signs-fur (altered appearance); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15695545_15695546:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a026ab6e122e3c2c4dce22cae7dbca56
ToxValDB ToxRefDB LEL >1280 mg/kg bw/day Rat oral short-term (developmental); 10 days developmental LONG_REF=NTP (1985) Teratologic evaluation of bisphenol A administered to CDAR rats on gestation days 6 through 15. NTP-85-089; TITLE=Teratologic evaluation of bisphenol A administered to CDAR rats on gestation days 6 through 15; AUTHOR=NTP; EXTERNAL_SOURCE_ID=2612; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ToxRefDB_dup_-_15695547_15695548_15695549_15695550:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a62d1ffb2ec6368ecce2ec3c640ff906
ToxValDB Uterotrophic Hershberger DB 24 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB Uterotrophic Hershberger DB LEL =0.0008 mg/day Mouse injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713836:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5445888e67bbfacc956a0c0671301676
ToxValDB Uterotrophic Hershberger DB LEL =0.00228291 mg Mouse injection acute; 0.17 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713696:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25ccf35863bd4424fc291290fd894e85
ToxValDB Uterotrophic Hershberger DB LEL =0.2 mg/kg bw/day Mouse injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713495_15713649_15714000:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e4d014dbb15f708b446d8a89f48b49d
ToxValDB Uterotrophic Hershberger DB LEL =0.5 mg/kg bw/day Rat injection short-term; 4 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15714003:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3613049237bd3f203b9ddb1055d4de65
ToxValDB Uterotrophic Hershberger DB LEL =0.8 mg/day Mouse injection short-term; 4 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713338:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e5a5ff89521e085bee47da75446b5e40
ToxValDB Uterotrophic Hershberger DB LEL =2 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_91efff6b16c72961b303c51a8ede3eff
ToxValDB Uterotrophic Hershberger DB LEL =5 mg/kg bw/day Mouse injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713495_15713649_15714000:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_14cbec1b32ca197eb47343fab73277d9
ToxValDB Uterotrophic Hershberger DB LEL =7.5 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1bc6e6e9863a94aedd563e524adadb3e
ToxValDB Uterotrophic Hershberger DB LEL =8 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f7d3dac1157288beab9871381bf55b89
ToxValDB Uterotrophic Hershberger DB LEL =10 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_578171280b87c194165da53b48e89e8e
ToxValDB Uterotrophic Hershberger DB LEL =11 mg/kg bw/day Rat injection short-term; 7 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713519:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e530fdd778d11c77a0ef877283b169f
ToxValDB Uterotrophic Hershberger DB LEL =20 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5b1a923a32cadb592bb1bc0b830f208c
ToxValDB Uterotrophic Hershberger DB LEL =30 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7c95f4da426ff66e2b74e7116a0b1c64
ToxValDB Uterotrophic Hershberger DB LEL =40 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7d67cffdfcf94f10a20937e5aacdb0f1
ToxValDB Uterotrophic Hershberger DB LEL =50 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0 |::| 1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a115ffd7c87497d93c0d0c19aeb3012
ToxValDB Uterotrophic Hershberger DB LEL =75 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_55178fbb3df18f797227417478f87a9b
ToxValDB Uterotrophic Hershberger DB LEL =100 mg/kg bw/day Mouse injection short-term; 4 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713597:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7b03eb65c3624205b50c88a1c8627919
ToxValDB Uterotrophic Hershberger DB LEL =150 mg/kg bw/day Rat lactation short-term; 7 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713622:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef9c583174dd8d812b9fb99af25054c9
ToxValDB Uterotrophic Hershberger DB LEL =160 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bcef2f977a0a683716ef1b2240918bbd
ToxValDB Uterotrophic Hershberger DB LEL =200 mg/kg bw/day Rat injection short-term; 2 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713631:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f4e8383505288db1f7a53455b6870eb
ToxValDB Uterotrophic Hershberger DB LEL =300 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0 |::| 1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_774b4dd735700301afc4113b3cc4c4d6
ToxValDB Uterotrophic Hershberger DB LEL =400 mg/kg bw/day Rat oral short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713627_15713633_15713663_15713681:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4eb6fd237ae7591b1d7148082b44714b
ToxValDB Uterotrophic Hershberger DB LEL =600 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cbdf84c04fb6249fda52f5eb95eb975f
ToxValDB Uterotrophic Hershberger DB LEL =800 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713476_15713498_15713501_15713508_15713528_15713550_15713557_15713574_15713586_15713603_15713626_15713635_15713656_15713664_15713673_15713680:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5527cd655dfda6ae351b9ba6f08d8c77
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier MLT3645I99 UNII - - - chemical -