Poor Cosmetic Ingredient NOAEL Data GHS Classified

4,4'-Isopropylidenediphenol (Bisphenol A / BPA)

INCI: 4,4'-ISOPROPYLIDENEDIPHENOL

CAS Number

80-05-7

Function

Not a functional cosmetic ingredient; industrial monomer that may appear as impurity or residue

Safety Rating

POOR

Regulatory Status

🇪🇺 EU Status prohibited

🇺🇸 US Status restricted

US Notes Not specifically banned in cosmetics by FDA but under scrutiny. EFSA and FDA have dramatically lowered acceptable exposure limits; no MoCRA-specific restriction yet

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

low

Sensitization

moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

8 study endpoints found for 4,4'-Isopropylidenediphenol (Bisphenol A / BPA). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOEL	30 ppm	oral	mouse	oral	REACH
NOEL	75 ppm	oral	rat	oral	REACH
NOAEL	>90 2106	1993	rat	inhalation	REACH
LOAEL	600 mg/kg bw/day	oral	rat	oral	REACH
LOAEL	25000 other	oral	rat	oral	REACH
LOAEL	250 ppm	oral	code:3544	oral	REACH
LOAEL	1000 ppm	oral	code:3544	oral	REACH
BMDL10	8.9 mg/kg bw/day	oral	-	oral	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

WARNING

Pictograms

excl mark;warn; cancer;health haz

Hazard Statements

Causes serious eye irritation May cause an allergic skin reaction Suspected of damaging fertility or the unborn child May cause respiratory irritation Toxic to aquatic life

Short-term Exposure Effects

The substance is severely irritating to the eyes. The substance is mildly irritating to the respiratory tract.

Long-term Exposure Effects

Repeated or prolonged contact may cause skin sensitization and photosensitization. The substance may have effects on the upper respiratory tract. Ingestion may cause effects on the liver and kidneys. Animal tests show that this substance possibly causes toxic effects upon human reproduction.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its aerosol.

Expert Verdict

Endocrine disruptor with estrogenic activity; reproductive toxicant (CMR 1B); neurodevelopmental concerns; environmental persistent pollutant

⚠️

Concern Level: High

Regulatory Flags

prop65 eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 4,4'-Isopropylidenediphenol (Bisphenol A / BPA) safe in cosmetics?

Endocrine disruptor with estrogenic activity; reproductive toxicant (CMR 1B); neurodevelopmental concerns; environmental persistent pollutant The EU classifies 4,4'-Isopropylidenediphenol (Bisphenol A / BPA) as "prohibited". Safety rating: POOR. 8 toxicological study endpoint(s) are available in our database.

Is 4,4'-Isopropylidenediphenol (Bisphenol A / BPA) allowed in the EU?

4,4'-Isopropylidenediphenol (Bisphenol A / BPA) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 4,4'-Isopropylidenediphenol (Bisphenol A / BPA) do in cosmetics?

4,4'-Isopropylidenediphenol (Bisphenol A / BPA) functions as: Not a functional cosmetic ingredient; industrial monomer that may appear as impurity or residue. It is classified as a cosmetic ingredient in our database. CAS number: 80-05-7.

What is the Margin of Safety for 4,4'-Isopropylidenediphenol (Bisphenol A / BPA)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 4,4'-Isopropylidenediphenol (Bisphenol A / BPA)?

The NOAEL (No Observed Adverse Effect Level) for 4,4'-Isopropylidenediphenol (Bisphenol A / BPA) is 30 ppm based on a oral study via oral route in mouse. A total of 8 study endpoints are available. Source: REACH.

Is 4,4'-Isopropylidenediphenol (Bisphenol A / BPA) classified as hazardous under GHS?

4,4'-Isopropylidenediphenol (Bisphenol A / BPA) carries a GHS signal word of "WARNING". Hazard statements: Causes serious eye irritation May cause an allergic skin reaction Suspected of damaging fertility or the unborn child May cause respiratory irritation Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check 4,4'-Isopropylidenediphenol (Bisphenol A / BPA) compliance across multiple jurisdictions:

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Heavy Metal Limits

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