NOAEL Studies Cosmetic Ingredient

5-Amino-4-Chloro-o-Cresol HCl NOAEL Studies

INCI: 5-AMINO-4-CHLORO-O-CRESOL HCL

CAS: 110102-85-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 180 mg/kg bw/day rat oral 90 day Subchronic SCCP; Potokar, M., Bartnik, F., Pittermann, W. (1987) 5-Amino-4-chlor-2-methylphenolhydrochlorid 90-Tage-Test mit wiederholter oraler Verabreichung anRatten Institut fur Toxikologie, Henkel KGaA Dusseldorf, Germany, Report No. 870036
SCCNFP Opinion 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =180 mg/kg bw/day rabbit dermal Sub-chronic repeated dose toxicity Ref. : 11 2, p.6
SCCS Opinion 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.19 mg/kg rat oral 90-day dermal absorption p.19
SCCS Opinion NOAEL =180 mg/kg bw/day rat - Chronic genotoxicity p.14
SCCS Opinion NOAEL =180 mg/kg bw rat oral 90-day dermal absorption p.19
SCCS Opinion NOAEL =500 mg/kg bw/day human oral - developmental toxicity p.19
Regulatory source 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source repeated dose toxicity 180 mg/kg bw/day rabbit dermal Sub-chronic repeated dose toxicity p.6
Regulatory source repeated dose toxicity 180 mg/kg bw/day rat - subchronic repeated dose toxicity p.18
Regulatory source dermal absorption =0.19 mg/kg rat oral 90-day dermal absorption p.19
Regulatory source dermal absorption =180 mg/kg bw rat oral 90-day dermal absorption p.19
Regulatory source developmental toxicity 500 mg/kg bw/day human oral - developmental toxicity p.19
Regulatory source genotoxicity 180 mg/kg bw/day rat - Chronic genotoxicity p.14
Regulatory source irritation 180 mg/kg bw/day rat - 90-day irritation p.20
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 31J4UQW59L UNII - - - chemical -