NOAEL Studies Cosmetic Ingredient

5-Amino-6-Chloro-o-Cresol NOAEL Studies

INCI: 5-AMINO-6-CHLORO-O-CRESOL

CAS: 84540-50-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 100 mg/kg bw/day rat oral 90 day Subchronic SCCS; van Otterdijk, F.M. Repeated dose 90-day oral toxicity study with A 094 by daily gavage in the rat followed by a 28-day recovery period. NOTOX B.V., Hertogenbosch, The Netherlands,HenkelKGaA, Düsseldorf Report No. R 0500279
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =24 mg/kg bw/d rat - developmental developmental toxicity p.21
SCCS Opinion NOAEL =30 mg/kg bw/d rat - 90-day irritation p.24
SCCS Opinion NOAEL =33 mg/kg bw/day rabbit dermal 90-day dermal absorption p.24
SCCS Opinion NOAEL =90 mg/kg/d rat - developmental developmental toxicity p.21
SCCS Opinion NOAEL =100 mg/kg/day - - - NOAEL study p.16
SCCS Opinion NOAEL =270 mg/kg bw/d rat - developmental developmental toxicity p.21
ECHA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =100 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf23e4b0a7c65d1ccad5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21096/7/6/2?documentUUID=c9875bba-b31c-4c06-8236-d32092717d74; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=clinical biochemistry|clinical signs|haematology|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|clinical signs|hematology|organ weight; STUDY_GROUP=ECHA IUCLID:15837141:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a5dedc3e6d7d082b320c2a62e3709202
ECHA NOAEL <750 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf23e4b0a7c65d1ccad8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21096/7/6/2?documentUUID=c9875bba-b31c-4c06-8236-d32092717d74; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=liver: body weight and weight gain|clinical signs|food consumption and compound intake|gross pathology|histopathology: neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|clinical signs|food and/or water consumption|gross pathology|organ weight; STUDY_GROUP=ECHA IUCLID:15843416:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fce139d26ce9d1afed3e153a838a4247
ECHA NOEL =90 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac7be4b0a7c65d1bf559; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21096/7/9/3?documentUUID=c9875bba-b31c-4c06-8236-d32092717d74; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15822650:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e0f23d4da19af806c00541672a44728d
ECHA NOEL =270 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac7be4b0a7c65d1bf559; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21096/7/9/3?documentUUID=c9875bba-b31c-4c06-8236-d32092717d74; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821333:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_47516db9723e9a264e0295fdf793f908
Regulatory source 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 100 mg/kg/day - - - - p.16
Regulatory source dermal absorption 33 mg/kg bw/day rabbit dermal 90-day dermal absorption p.24
Regulatory source developmental toxicity 24 mg/kg bw/d rat - developmental developmental toxicity p.21
Regulatory source developmental toxicity 90 mg/kg/d rat - developmental developmental toxicity p.21
Regulatory source developmental toxicity 270 mg/kg bw/d rat - developmental developmental toxicity p.21
Regulatory source irritation 30 mg/kg bw/d rat - 90-day irritation p.24
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8077WHL3XK UNII - - - chemical -