Is 5-Amino-6-Chloro-o-Cresol safe in cosmetics?
5-Amino-6-Chloro-o-Cresol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
5-Amino-6-Chloro-o-Cresol
Also known as: EINECS 283-144-9, UNII-8077WHL3XK
INCI: 5-AMINO-6-CHLORO-O-CRESOL
5-Amino-6-Chloro-o-Cresol (CAS 84540-50-1) is a cosmetic cosmetic ingredient functioning as Hair colorant (oxidative and semi-permanent hair dyes). NOAEL 425 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 84540-50-1 →
Auto-generated CPSR Part A draft with source citations
Function
Hair colorant (oxidative and semi-permanent hair dyes)
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR previously concluded safe (2004) for oxidative and semi-permanent hair dyes as part of a 6-ingredient amino-cresol assessment; re-review pending as individual report
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 5-Amino-6-Chloro-o-Cresol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 5-Amino-6-Chloro-o-Cresol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =24 mg/kg bw/d | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =24 mg/kg bw/d | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =24 mg/kg bw/d | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =24 mg/kg bw/d | - | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =30 mg/kg bw/d | - | rat | irritation | SCCS_vision_codex |
| NOAEL | =30 mg/kg bw/d | - | rat | irritation | SCCS_vision_codex |
| NOAEL | =30 mg/kg bw/d | - | rat | irritation | SCCS_vision_codex |
| NOAEL | =30 mg/kg bw/d | - | rat | irritation | SCCS_vision_codex |
| NOAEL | =33 mg/kg bw/day | dermal | rabbit | dermal absorption | SCCS_vision_codex |
| NOAEL | =33 mg/kg bw/day | dermal | rabbit | dermal absorption | SCCS_vision_codex |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 5-Amino-6-Chloro-o-Cresol across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for 5-Amino-6-Chloro-o-Cresol based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: SCCS; IVDK
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
18.4%
DPRA Lys %
35.4%
KeratinoSens IC50
968.4 µM
hCLAT CV75
409.6 µg/mL
LLNA EC3
50%
NESIL
12500 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Source: LLNA: CosmEur database; DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: Restricted. Max: 산화염모제에 1.0%, 비산화염모제에 0.5%. 기타 제품에는 사용금지
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 1 | Oxidative hair dye products |
| BR | permitted_hair_dye | - | Oxidative hair dye |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "dye", "cross_reactivity_group": "para-amino-group", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "SCCS; IVDK"}
hair_dye
{"cas_number": "84540-50-1", "ingredient_class": "oxidative_dye_coupler", "chemical_class": "other", "molecular_weight_Da": "157.60", "color_result_on_hair": "Red-brown modifier", "shade_range": "red", "primary_function": "coupler", "oxidative_dye_type": "coupler", "requires_developer": "yes", "permanence": "permanent", "oxidation_mechanism": "coupling", "hair_penetration_depth": "cortex", "sensit…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Dye
Expert Verdict
Expert safety assessment and concern-level summary for 5-Amino-6-Chloro-o-Cresol.
Regulatory Flags
colorant
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 5-Amino-6-Chloro-o-Cresol by CAS number or substance name.
Studies
25
Lowest NOAEL
24
Highest NOAEL
270
Units vary across source rows: mg/kg bw/day, mg/kg/day, mg/kg/d
ToxValDB_ECHA_IUCLID
SCCS_vision_codex
Known Synonyms
EINECS 283-144-9
UNII-8077WHL3XK
Chemical Function
Biocide
Dye
Regulatory Lists
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Frequently Asked Questions
Is 5-Amino-6-Chloro-o-Cresol allowed in the EU?
5-Amino-6-Chloro-o-Cresol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 5-Amino-6-Chloro-o-Cresol do in cosmetics?
5-Amino-6-Chloro-o-Cresol functions as: Hair colorant (oxidative and semi-permanent hair dyes). It is classified as a cosmetic ingredient in our database. CAS number: 84540-50-1.
What is the NOAEL for 5-Amino-6-Chloro-o-Cresol?
The NOAEL (No Observed Adverse Effect Level) for 5-Amino-6-Chloro-o-Cresol is =24 mg/kg bw/d based on a developmental toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is 5-Amino-6-Chloro-o-Cresol used outside cosmetics?
5-Amino-6-Chloro-o-Cresol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 5-Amino-6-Chloro-o-Cresol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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