5-Amino-6-Chloro-o-Cresol
INCI: 5-AMINO-6-CHLORO-O-CRESOL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for 5-Amino-6-Chloro-o-Cresol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 100 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 750 mg/kg bw/day | oral | rat | oral | REACH |
Sensitization Profile
Contact sensitization data for 5-Amino-6-Chloro-o-Cresol based on clinical patch test studies and IFRA standards.
Source: SCCS; IVDK
Expert Verdict
Several related amino-cresols have been banned in EU, triggering re-review of this ingredient despite current permitted status.
Regulatory Flags
Frequently Asked Questions
Is 5-Amino-6-Chloro-o-Cresol safe in cosmetics?
Several related amino-cresols have been banned in EU, triggering re-review of this ingredient despite current permitted status. The EU classifies 5-Amino-6-Chloro-o-Cresol as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is 5-Amino-6-Chloro-o-Cresol allowed in the EU?
5-Amino-6-Chloro-o-Cresol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 5-Amino-6-Chloro-o-Cresol do in cosmetics?
5-Amino-6-Chloro-o-Cresol functions as: Hair colorant (oxidative and semi-permanent hair dyes). It is classified as a cosmetic ingredient in our database. CAS number: 84540-50-1.
What is the Margin of Safety for 5-Amino-6-Chloro-o-Cresol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 5-Amino-6-Chloro-o-Cresol?
The NOAEL (No Observed Adverse Effect Level) for 5-Amino-6-Chloro-o-Cresol is 100 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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