Is 5-Amino-6-Chloro-o-Cresol safe in cosmetics?
5-Amino-6-Chloro-o-Cresol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
5-Amino-6-Chloro-o-Cresol
Also known as: EINECS 283-144-9, UNII-8077WHL3XK
INCI: 5-AMINO-6-CHLORO-O-CRESOL
5-Amino-6-Chloro-o-Cresol (CAS 84540-50-1) is a cosmetic cosmetic ingredient functioning as Hair colorant (oxidative and semi-permanent hair dyes). NOAEL 425 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 84540-50-1 →
Function
Hair colorant (oxidative and semi-permanent hair dyes)
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR previously concluded safe (2004) for oxidative and semi-permanent hair dyes as part of a 6-ingredient amino-cresol assessment; re-review pending as individual report
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 5-Amino-6-Chloro-o-Cresol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 5-Amino-6-Chloro-o-Cresol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =24 mg/kg bw/d | - | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =24 mg/kg bw/d | - | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =24 mg/kg bw/d | - | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =24 mg/kg bw/d | - | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =30 mg/kg bw/d | - | rat | irritation | SCCS Opinion |
| NOAEL | =30 mg/kg bw/d | - | rat | irritation | SCCS Opinion |
| NOAEL | =30 mg/kg bw/d | - | rat | irritation | SCCS Opinion |
| NOAEL | =30 mg/kg bw/d | - | rat | irritation | SCCS Opinion |
| NOAEL | =33 mg/kg bw/day | dermal | rabbit | dermal absorption | SCCS Opinion |
| NOAEL | =33 mg/kg bw/day | dermal | rabbit | dermal absorption | SCCS Opinion |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 5-Amino-6-Chloro-o-Cresol across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for 5-Amino-6-Chloro-o-Cresol based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: SCCS; IVDK
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
18.4%
DPRA Lys %
35.4%
KeratinoSens IC50
968.4 µM
hCLAT CV75
409.6 µg/mL
LLNA EC3
50%
NESIL
12500 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Source: LLNA: CosmEur database; DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: Restricted. Max: 산화염모제에 1.0%, 비산화염모제에 0.5%. 기타 제품에는 사용금지
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 1 | Oxidative hair dye products |
| BR | permitted_hair_dye | - | Oxidative hair dye |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Dye
Editorial summary
Preliminary editorial summary for 5-Amino-6-Chloro-o-Cresol — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
colorant
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 5-Amino-6-Chloro-o-Cresol by CAS number or substance name.
Studies
25
Lowest NOAEL
24
Highest NOAEL
270
Units vary across source rows: mg/kg bw/d, mg/kg bw/day, mg/kg/d
SCCS Opinion
ECHA
Known Synonyms
EINECS 283-144-9
UNII-8077WHL3XK
Chemical Function
Biocide
Dye
Regulatory Lists
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Frequently Asked Questions
Is 5-Amino-6-Chloro-o-Cresol allowed in the EU?
5-Amino-6-Chloro-o-Cresol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 5-Amino-6-Chloro-o-Cresol do in cosmetics?
5-Amino-6-Chloro-o-Cresol functions as: Hair colorant (oxidative and semi-permanent hair dyes). It is classified as a cosmetic ingredient in our database. CAS number: 84540-50-1.
What is the NOAEL for 5-Amino-6-Chloro-o-Cresol?
The NOAEL (No Observed Adverse Effect Level) for 5-Amino-6-Chloro-o-Cresol is =24 mg/kg bw/d based on a developmental toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
Is 5-Amino-6-Chloro-o-Cresol used outside cosmetics?
5-Amino-6-Chloro-o-Cresol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 5-Amino-6-Chloro-o-Cresol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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