NOAEL Studies Cosmetic Ingredient

5-Bromo-5-Nitro-1,3-Dioxane NOAEL Studies

INCI: 5-BROMO-5-NITRO-1,3-DIOXANE

CAS: 30007-47-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =50 - Wistar rat oral (gavage) 17 weeks, 5 times per week NOAEL study {"citation":"5-7","page":5,"pdf":"pr140.pdf","row_type":"noael_study","study_id":"beta_pr140_noael_001"}
CIR Safety Assessment NOAEL =50 - Wistar rat oral (gavage) 17 weeks, 5 times per week NOAEL study {"citation":"5-7","page":5,"pdf":"pr140.pdf","row_type":"noael_study","study_id":"beta_pr140_noael_001"}
CIR Safety Assessment NOAEL =50 - Wistar rat oral (gavage) 17 weeks, 5 times per week NOAEL study {"citation":"5-7","page":5,"pdf":"pr140.pdf","row_type":"noael_study","study_id":"beta_pr140_noael_001"}
CIR Safety Assessment NOAEL =50 - Wistar rat oral (gavage) 17 weeks, 5 times per week NOAEL study {"citation":"5-7","page":5,"pdf":"pr140.pdf","row_type":"noael_study","study_id":"beta_pr140_noael_001"}
ECHA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL ~5 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd600; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25164/7/9/3?documentUUID=2bccb682-e010-4fca-ade7-bb065e5981a5; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=maternal: clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID:15824727:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_176a81732e314c15a155c2363d248a97
ECHA NOAEL ~15 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd600; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25164/7/9/3?documentUUID=2bccb682-e010-4fca-ade7-bb065e5981a5; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15824728:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f533e9be3bffae7f2df99c74692f17cd
ECHA NOAEL =45 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd5fe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25164/7/9/3?documentUUID=2bccb682-e010-4fca-ade7-bb065e5981a5; YEAR=1974; ORIGINAL_YEAR=1974; STUDY_GROUP=ECHA IUCLID:15824726:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3adf7a520e2220189c129dd3f862aabd
ECHA NOAEL ~50 mg/kg bw/day Rat oral chronic; 14 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae13e4b0a7c65d1c749b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25164/7/6/2?documentUUID=2bccb682-e010-4fca-ade7-bb065e5981a5; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=gross pathology|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|mortality/survival; STUDY_GROUP=ECHA IUCLID:15849380:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_54c9507e7cb61c56a19fccecdbbebd65
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =0.0274 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630324:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_93b084214b468570a92aaeb865bb9268
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier U184I9QBNM UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6BrNO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U184I9QBNM"}
openFDA substances FDA UNII substance identifier U184I9QBNM UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6BrNO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U184I9QBNM"}
openFDA substances FDA UNII substance identifier U184I9QBNM UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6BrNO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U184I9QBNM"}
openFDA substances FDA UNII substance identifier U184I9QBNM UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6BrNO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U184I9QBNM"}