Also known as: 1,3-Dioxane, 5-bromo-5-nitro-, BRN 4668673, 5-Bromo-5-nitro-m-dioxane, Bronidox, EINECS 250-001-7 (+2 more)
INCI: 5-BROMO-5-NITRO-1,3-DIOXANE
5-Bromo-5-Nitro-1,3-Dioxane (CAS 30007-47-7) is a cosmetic cosmetic ingredient functioning as Preservative (antimicrobial; formaldehyde releaser). NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted, max 0.1%; 1 safety opinion reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
5-Bromo-5-Nitro-1,3-Dioxane is classified GHS Danger (H302, H314, H315, H317, H318, H373, H400, H410) in the chemicals database but is allowed in EU cosmetics at max 0.1%.
US NotesCIR concluded safe up to 0.1%, except where it can form nitrosamines/nitrosamides with amines or amides
For full compliance data across multiple jurisdictions, use the
Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 5-Bromo-5-Nitro-1,3-Dioxane.
Calculate MoS for your specific formulation with the
MoS Calculator.
Toxicological Studies
1 study endpoint found for 5-Bromo-5-Nitro-1,3-Dioxane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=45 mg/kg bw/day
oral
Rat
developmental
ECHA
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
CIR Safety Assessment
Verdict: unknown
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 5-Bromo-5-Nitro-1,3-Dioxane across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for 5-Bromo-5-Nitro-1,3-Dioxane based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
preservative
EU Allergen Listed
no
Patch Test Positive Rate
0.5%
Cross-reactivity Group
formaldehyde-releaser-group
Reaction Type
contact-dermatitis
Source: FDA
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex V — Permitted Preservatives
Product type: Rinse-off products
Max: 0.1%
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Europe; Personal carechildren; Europe; Personal care - body hygiene - body washchildren; Europe; Personal care - specialized bath products - bubble bathchildren; Europe; Personal carechildren; Europe; Personal carechildren; Europe; Personal carechildren; Europe; Personal careactive_ingredient; Europe; Pesticides
Australian Status
AICIS status:listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCEChEMBL / DrugCentral / FAERSDB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
5-Bromo-5-Nitro-1,3-Dioxane has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
Is 5-Bromo-5-Nitro-1,3-Dioxane allowed in the EU?
5-Bromo-5-Nitro-1,3-Dioxane EU regulatory status: permitted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.
What does 5-Bromo-5-Nitro-1,3-Dioxane do in cosmetics?
5-Bromo-5-Nitro-1,3-Dioxane functions as: Preservative (antimicrobial; formaldehyde releaser). It is classified as a cosmetic ingredient in our database. CAS number: 30007-47-7.
What is the NOAEL for 5-Bromo-5-Nitro-1,3-Dioxane?
The NOAEL (No Observed Adverse Effect Level) for 5-Bromo-5-Nitro-1,3-Dioxane is =45 mg/kg bw/day based on a developmental study via oral route in Rat. Source: ECHA.
Is 5-Bromo-5-Nitro-1,3-Dioxane used outside cosmetics?
5-Bromo-5-Nitro-1,3-Dioxane also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 5-Bromo-5-Nitro-1,3-Dioxane have different safety status in cosmetics vs industrial chemicals?
5-Bromo-5-Nitro-1,3-Dioxane is classified GHS Danger (H302, H314, H315, H317, H318, H373, H400, H410) in the chemicals database but is allowed in EU cosmetics at max 0.1%.
Compliance Tools
Check 5-Bromo-5-Nitro-1,3-Dioxane compliance across multiple jurisdictions:
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 5-Bromo-5-Nitro-1,3-Dioxane in your formulation.