5-Bromo-5-Nitro-1,3-Dioxane
INCI: 5-BROMO-5-NITRO-1,3-DIOXANE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for 5-Bromo-5-Nitro-1,3-Dioxane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | ca.50 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Sensitization Profile
Contact sensitization data for 5-Bromo-5-Nitro-1,3-Dioxane based on clinical patch test studies and IFRA standards.
Source: ESSCA 2019/20; IVDK; FDA
Expert Verdict
Formaldehyde releaser that requires careful formulation to avoid nitrosamine formation; must not be used with nitrosating agents or amine/amide-containing ingredients; requires formaldehyde labeling if free formaldehyde exceeds 0.05%.
Regulatory Flags
Frequently Asked Questions
Is 5-Bromo-5-Nitro-1,3-Dioxane safe in cosmetics?
Formaldehyde releaser that requires careful formulation to avoid nitrosamine formation; must not be used with nitrosating agents or amine/amide-containing ingredients; requires formaldehyde labeling if free formaldehyde exceeds 0.05%. The EU classifies 5-Bromo-5-Nitro-1,3-Dioxane as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is 5-Bromo-5-Nitro-1,3-Dioxane allowed in the EU?
5-Bromo-5-Nitro-1,3-Dioxane EU regulatory status: permitted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.
What does 5-Bromo-5-Nitro-1,3-Dioxane do in cosmetics?
5-Bromo-5-Nitro-1,3-Dioxane functions as: Preservative (antimicrobial; formaldehyde releaser). It is classified as a cosmetic ingredient in our database. CAS number: 30007-47-7.
What is the Margin of Safety for 5-Bromo-5-Nitro-1,3-Dioxane?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 5-Bromo-5-Nitro-1,3-Dioxane?
The NOAEL (No Observed Adverse Effect Level) for 5-Bromo-5-Nitro-1,3-Dioxane is ca.50 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
Check 5-Bromo-5-Nitro-1,3-Dioxane compliance across multiple jurisdictions:
Related Ingredients
Is 5-Bromo-5-Nitro-1,3-Dioxane in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 5-Bromo-5-Nitro-1,3-Dioxane in your formulation.