NOAEL Studies Cosmetic Ingredient

Acacia Senegal Gum NOAEL Studies

CAS: 9000-01-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 800 mg/kg bw/day rabbit oral 13 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1600 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 3117 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 5000 mg/kg bw/day rat oral 721 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 6000 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 7500 mg/kg bw/day mouse oral 721 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 10000 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 10647 mg/kg bw/day rat oral 111 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 13900 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 15000 mg/kg bw/day mouse oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 25000 mg/kg bw/day mouse oral 8 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 30000 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 80000 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =2500 mg/kg bw/day Rat - - chronic/long term toxicity EFSA FEEDAP - 2022 - OutputID 4122 - Safety and efficacy of a feed additive consisting of acacia gum (gum Arabic) for all animal species (A.I.P.G. Association for International Promotion of Gums) - doi:10.2903/j.efsa.2022.7252
EFSA LEL =760 mg/kg bw/day Human oral short-term; 18 days clinical LONG_REF=EFSA ANS (2017). Re-evaluation of acacia gum (E 414) as a food additive. doi:10.2903/j.efsa.2017.4741.; TITLE=Re-evaluation of acacia gum (E 414) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2017.4741; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15625039:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a4227c13f217545ec225ad1671e5e0f9
EFSA LEL =2500 mg/kg bw/day Rat oral chronic; 103 weeks chronic LONG_REF=EFSA ANS (2017). Re-evaluation of acacia gum (E 414) as a food additive. doi:10.2903/j.efsa.2017.4741.; TITLE=Re-evaluation of acacia gum (E 414) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2017.4741; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15625037:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e6f45e67dcfaa1f1409fed6d8540f87
EFSA LEL =5220 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=EFSA FAF (2019). Opinion on the re-evaluation of acacia gum (E 414) as a food additive in foods for infants below 16 weeks of age and the follow-up of its re-evaluation as a food additive for uses in foods for all population groups. doi:10.2903/j.efsa.2019.5922.; TITLE=Opinion on the re-evaluation of acacia gum (E 414) as a food additive in foods for infants below 16 weeks of age and the follow-up of its re-evaluation as a food additive for uses in foods for all population groups; AUTHOR=EFSA FAF; DOI=doi:10.2903/j.efsa.2019.5922; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15625040:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bde159dec99f5a50682be06a7aacec52
EFSA LEL =7500 mg/kg bw/day Mouse oral chronic; 103 weeks chronic LONG_REF=EFSA ANS (2017). Re-evaluation of acacia gum (E 414) as a food additive. doi:10.2903/j.efsa.2017.4741.; TITLE=Re-evaluation of acacia gum (E 414) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2017.4741; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15625038:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8b8ad8df2ccc936bc9028766e9dfa39c
EFSA LEL =20000 mg/kg bw/day Mouse oral - subchronic LONG_REF=EFSA FAF (2019). Opinion on the re-evaluation of acacia gum (E 414) as a food additive in foods for infants below 16 weeks of age and the follow-up of its re-evaluation as a food additive for uses in foods for all population groups. doi:10.2903/j.efsa.2019.5922.; TITLE=Opinion on the re-evaluation of acacia gum (E 414) as a food additive in foods for infants below 16 weeks of age and the follow-up of its re-evaluation as a food additive for uses in foods for all population groups; AUTHOR=EFSA FAF; DOI=doi:10.2903/j.efsa.2019.5922; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15625041:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_38002a7f8512b9f235732ad7f0fd54f7
NTP ICE cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer Top dose 50000 ppm Mouse Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=8745; Record_ID=cancer_96; Data_Type=In Vivo; Formulation_Name=Gum arabic; Mixture=Chemical; DTXSID=DTXSID8020676; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=50000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed feed; Reference=TR-227; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr227/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020676
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 5C5403N26O UNII - - - structurallyDiverse -