NOAEL Studies
Cosmetic Ingredient
ACETALDEHYDE NOAEL Studies
CAS: 75-07-0
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 675 | mg/kg bw/day | rat | oral | 31 day | Short Term Toxicity | PAFA;SCCS; FOOD CHEM TOXICOL 26:447-452, |
| COSMOS DB | NOAEL | 10 | mg/kg bw/day | guinea pig | oral | 113 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 675 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 400 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 240 | mg/kg bw/day | rat | oral | 42 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 324 | mg/kg bw/day | rat | oral | 240 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 125 | mg/kg bw/day | rat | oral | 1085 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
California Proposition 65 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 NSRL | SQEinhalation=90 | ug/day | - | - | 1988-04-01 | No significant risk level | - |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1988-04-01 | California Proposition 65 listing | - |
EFSA 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =120 | mg/kg bw/day | Rat | oral: drinking water | 77 days | subchronic | EFSA FEEDAP - 2013 - OutputID 2209 - other - hepatotoxicity - Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species - doi:10.2903/j.efsa.2013.3169 |
| EFSA | NOEL | =125 | mg/kg bw/day | Rat | - | 28 days | short-term toxicity | EFSA CEF - 2010 - OutputID 2042 - Scientific Opinion on Flavouring Group Evaluation 91 (FGE.91): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev1 (2009). EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) - doi:10.2903/j.efsa.2010.1337 |
| EFSA | NOAEL | =120 | mg/kg bw/day | Rat | oral | subchronic; 11 weeks | subchronic | LONG_REF=EFSA FEEDAP (2013). Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species. doi:10.2903/j.efsa.2013.3169.; TITLE=Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2013.3169; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=other; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=EFSA:15621824:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c90b4b76f2b0fcefcc90656c4b54782e |
| EFSA | NOEL | =125 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | LONG_REF=EFSA CEF (2010). Scientific Opinion on Flavouring Group Evaluation 91 (FGE.91): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev1 (2009). EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF). doi:10.2903/j.efsa.2010.1337.; TITLE=Scientific Opinion on Flavouring Group Evaluation 91 (FGE.91): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev1 (2009). EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2010.1337; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=EFSA:15621823:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e73d9649700b4ad55e05a053a822a39e |
Regulatory source 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL (HEC) | =8.7 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=10400ab902b567d1; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (HEC): 8.7 mg/m^3; system=Nervous, Respiratory; basis=Degeneration of olfactory epithelium; point_of_departure=NOAEL (HEC): 8.7 mg/m^3; composite_uf=1000; confidence=Low; dtxsid=DTXSID5039224; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=290; rfc_last_updated=10/01/1991; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0290_summary.pdf |
| Regulatory source | RfC | =0.009 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=e05b1d336cfea136; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=9e-3; system=Nervous, Respiratory; basis=Degeneration of olfactory epithelium; point_of_departure=NOAEL (HEC): 8.7 mg/m^3; composite_uf=1000; confidence=Low; dtxsid=DTXSID5039224; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=290; rfc_last_updated=10/01/1991; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0290_summary.pdf |
| Regulatory source | - | 5 | ppm | rat | inhalation | 28 day | - | p.27 |
| Regulatory source | - | 400 | ppm | rat | inhalation | 28 days | - | p.12 |
| Regulatory source | - | 500 | mg/kg bw/day | rat | - | 6 months | - | p.13 |
| Regulatory source | carcinogenicity | 0.5 | mg/kg bw/d | rat | dermal | 3 month | carcinogenicity | p.13 |
| Regulatory source | genotoxicity | 125 | mg/kg bw/d | rat | dermal | 4 week | genotoxicity | p.28 |
| Regulatory source | repeated dose toxicity | 125 | mg/kg bw/d | - | inhalation | 28 days | repeated dose toxicity | p.11 |
| Regulatory source | repeated dose toxicity | 150 | ppm | rat | oral | 5 days | repeated dose toxicity | p.12 |
Health Canada Drug Product Database 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Health Canada Drug Product Database | Health Canada DPD product listing | 2233545 | DIN | Human | - | 2025-03-22 | Health Canada Drug Product Database | - |
IARC Monographs 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 1 | IARC group | - | - | 2009 | IARC Monographs | - |
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 1998 | IARC Monographs | - |
WHO/JECFA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOEL | =675 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc167; title=Acetaldehyde (EHC 167, 1995); path=mirror/documents/ehc/ehc/ehc167.htm; row_hash=01f9a88f66886fe5; raw_unit=mg/kg; context=The no-observed-effect level (NOEL) was 125 mg/kg, the lowest-observed-effect level (LOEL) was 675 mg/kg (Til et al., 1988). |
| WHO/JECFA | NOEL | =125 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc167; title=Acetaldehyde (EHC 167, 1995); path=mirror/documents/ehc/ehc/ehc167.htm; row_hash=36b9647358fda2e5; raw_unit=mg/kg; context=En un estudio de 28 días en el que se administró a ratas con el agua de beber acetaldehído a razón de 675 mg/kg de peso corporal (nivel sin efecto observado (NOEL) = 125 mg/kg de peso corporal) los efectos se limitaron a una ligera hiperqueratosis focal en la parte anterior del estómago. |
| WHO/JECFA | NOEL | =255 | mg/m3 | - | - | - | Toxicology study | document_id=ehc_ehc_ehc167; title=Acetaldehyde (EHC 167, 1995); path=mirror/documents/ehc/ehc/ehc167.htm; row_hash=9c45cd03a505be41; raw_unit=mg/m 3; context=The NOEL was 255 mg/m 3 , 6-h TWA (LOEL = 1050 mg/m 3 , 6-h time weighted average) (Appelman et al., 1986). |
| WHO/JECFA | NOEL | =275 | mg/m3 | Rat | - | 4-week | Carcinogenicity | document_id=ehc_ehc_ehc167; title=Acetaldehyde (EHC 167, 1995); path=mirror/documents/ehc/ehc/ehc167.htm; row_hash=780be76dc3136233; raw_unit=mg/m 3; context=275 mg/m 3 was the NOEL for irritation in rats in a 4-week study (Appelman et al., 1986) and 1000 is the uncertainty factor (×10 for interspecies variation, ×10 for intraspecies variation and ×10 for a less than long-term study and severity of effect, i.e., carcinogenicity associate |
| WHO/JECFA | NOEL | =700 | mg/m3 | - | - | - | Toxicology study | document_id=ehc_ehc_ehc167; title=Acetaldehyde (EHC 167, 1995); path=mirror/documents/ehc/ehc/ehc167.htm; row_hash=95a544f0ee8f95b0; raw_unit=mg/m 3; context=At 700 mg/m 3 , no significant effects were observed (NOEL: |
NTP ICE acute inhalation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 23.9485 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3179; Record_ID=acute_inhalation_2789; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5039224; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=23.9485; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5039224; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5039224 |
| NTP ICE acute inhalation | LC50 | 24 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3178; Record_ID=acute_inhalation_2331; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5039224; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=24; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5039224; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5039224 |
| NTP ICE acute inhalation | LC50 | 25 | mg/L | - | Inhalation | - | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3180; Record_ID=acute_inhalation_1703; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5039224; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=25; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5039224; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5039224 |
| NTP ICE acute inhalation | LC50 | 37 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3181; Record_ID=acute_inhalation_2327; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5039224; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=37; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5039224; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5039224 |
| NTP ICE acute inhalation | LC50 | 37.3092 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3182; Record_ID=acute_inhalation_2329; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5039224; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=37.3092; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5039224; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5039224 |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =661 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10002; row=9276; data_type=In Vivo; mixture=Chemical; chemical_name=Acetaldehyde; preferred_name=Acetaldehyde; dtxsid=DTXSID5039224; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5039224; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5039224; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1930 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10004; row=9277; data_type=In Vivo; mixture=Chemical; chemical_name=Acetaldehyde; preferred_name=Acetaldehyde; dtxsid=DTXSID5039224; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5039224; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5039224; source_file=acute_oral.xlsx |
NTP ICE cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=6207; Record_ID=cancer_3673; Data_Type=WOE; Formulation_Name=Acetaldehyde; Mixture=Chemical; DTXSID=DTXSID5039224; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/54; http://publications.iarc.fr/139; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5039224; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5039224 |
| NTP ICE cancer | Inhalation risk unit | 0.0000022 | ug/m3 | - | Inhalation | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=6210; Record_ID=cancer_3675; Data_Type=WOE; Formulation_Name=Acetaldehyde; Mixture=Chemical; DTXSID=DTXSID5039224; Assay=IRIS Carcinogenicity; Endpoint=Inhalation risk unit; Response=2.2000000000000001E-6; Response_Unit=ug/m3; Route=Inhalation; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0290_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5039224; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5039224 |
SCCS Opinion 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.5 | mg/kg bw/d | rat | dermal | 3 month | carcinogenicity | p.13 |
| SCCS Opinion | NOAEL | =5 | ppm | rat | inhalation | 28 day | NOAEL study | p.27 |
| SCCS Opinion | NOAEL | =125 | mg/kg bw/d | - | inhalation | 28 days | repeated dose toxicity | p.11 |
| SCCS Opinion | NOAEL | =150 | ppm | rat | oral | 5 days | repeated dose toxicity | p.12 |
| SCCS Opinion | NOAEL | =400 | ppm | rat | inhalation | 28 days | NOAEL study | p.12 |
| SCCS Opinion | NOAEL | =500 | mg/kg bw/day | rat | - | 6 months | NOAEL study | p.13 |
ToxValDB Cal OEHHA REL derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | BMC (05) | =178 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | LONG_REF=Appelman LM, Woutersen RA and Feron VJ (1982). Inhalation toxicity of acetaldehyde in rats. I. Acute and subacute studies. Toxicology 23(4): 293-307. Appelman LM, Woutersen RA, Feron VJ, Hooftman RN and Notten WR (1986). Effect of variable versus fixed exposure levels on the toxicity of acetaldehyde in rats. J Appl Toxicol 6(5): 331-336.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd1final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=degeneration of olfactory epithelium; STUDY_GROUP=Cal OEHHA REL derivations:15951852:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c2a50eb65f47256cc07d371e42cc2ed0 |
| ToxValDB Cal OEHHA REL derivations | LOAEL | =142 | mg/m3 | Human | inhalation | acute; 6 minutes | clinical | LONG_REF=Prieto L, Sanchez-Toril F, Brotons B, Soriano S, Casan R and Belenguer JL (2000). Airway responsiveness to acetaldehyde in patients with asthma: Relationship to methacholine responsiveness and peak expiratory flow variation. Clin Exp Allergy 30(1): 71-78; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd1final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Bronchoconstriction, PC20 >20% drop in FEV1; STUDY_GROUP=Cal OEHHA REL derivations:15951850:-:-asthmatic volunteers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a52a5decc6a28f51fa371db8f3310849 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =72070.7 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=DOE Protective Action Criteria:15511749:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4fbdec93ab8ab61aeb4f1b70302332e2 |
ECHA 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | =125 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/33836/7/3/2?documentUUID=886c3edc-944b-48cd-a56c-965049ac8387; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15807032_15807033:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_21f80b308fcb7ca5846996ca6e347e1a |
| ECHA | LEL | =675 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/33836/7/3/2?documentUUID=886c3edc-944b-48cd-a56c-965049ac8387; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15807032_15807033:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_56e7042f3d916007966c15507d5e3c1e |
| ECHA | NOAEL | =6000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c93ee4b0a7c65d21c2bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/33836?documentUUID=5e85f61d-206b-406e-978b-494f531da7ba; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15857717:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee2769907b3cb71f1949e8de475f25a8 |
| ECHA | NOAEL | =12000 | ppm | Rat | oral | short-term; 3 weeks | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbc8e4b0a7c65d227874; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/33836?documentUUID=5e85f61d-206b-406e-978b-494f531da7ba; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15829739:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8796f2fb0827305c6af91c5f83364f45 |
ToxValDB ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =50 | mg/100 mL | Mouse | environmental | short-term; 3 days | developmental | LONG_REF=Experientia45(5): 484-487 Kalmus,G.W., and C.C. Buckenmaier III Effects of Ethanol and Acetaldehyde on Cultured Pre-Implantation Mouse Embryos 1989; TITLE=Effects of Ethanol and Acetaldehyde on Cultured Pre-Implantation Mouse Embryos; AUTHOR=Kalmus,G.W., and C.C. Buckenmaier III; DOI=10.1007/BF01952040; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112963; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Development: Stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604985_15604986:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9941f142c819b70ea026f332cb639b16 |
| ToxValDB ECOTOX | NOEL | =10 | mg/100 mL | Mouse | environmental | short-term; 3 days | developmental | LONG_REF=Experientia45(5): 484-487 Kalmus,G.W., and C.C. Buckenmaier III Effects of Ethanol and Acetaldehyde on Cultured Pre-Implantation Mouse Embryos 1989; TITLE=Effects of Ethanol and Acetaldehyde on Cultured Pre-Implantation Mouse Embryos; AUTHOR=Kalmus,G.W., and C.C. Buckenmaier III; DOI=10.1007/BF01952040; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112963; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Development: Stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604985_15604986:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=947ebb690875bbe57079bbbc123f92d5 |
ToxValDB IRIS 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =728 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | LONG_REF=Appleman, L.M., R.A. Woutersen, V.J. Feron, R.N. Hooftman and W.R.F. Notten. 1986. Effect of variable versus fixed exposure levels on the toxicity of acetaldehyde in rats. J. Appl. Toxicol. 6(5): 331-336. ; Appleman, L.M., R.A. Woutersen, and V.J. Feron. 1982. Inhalation toxicity of acetaldehyde in rats. I. Acute and subacute studies. Toxicology. 23: 293-297.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a545f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=290; TOXICOLOGICAL_EFFECT=degeneration of olfactory epithelium; STUDY_GROUP=IRIS_dup_IRIS Summary_15644188_15644189_15644190_15644191_15644192_15644193:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4f6c78dec2aae8e9a3e4d457f37ea4b2 |
| ToxValDB IRIS | LOAEL (ADJ) | =130 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | LONG_REF=Appleman, L.M., R.A. Woutersen, V.J. Feron, R.N. Hooftman and W.R.F. Notten. 1986. Effect of variable versus fixed exposure levels on the toxicity of acetaldehyde in rats. J. Appl. Toxicol. 6(5): 331-336. ; Appleman, L.M., R.A. Woutersen, and V.J. Feron. 1982. Inhalation toxicity of acetaldehyde in rats. I. Acute and subacute studies. Toxicology. 23: 293-297.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a545f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=290; TOXICOLOGICAL_EFFECT=degeneration of olfactory epithelium; STUDY_GROUP=IRIS_dup_IRIS Summary_15644188_15644189_15644190_15644191_15644192_15644193:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_11acbcc93ec1185b183bbca1adb6ea75 |
| ToxValDB IRIS | LOAEL (HEC) | =16.9 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | LONG_REF=Appleman, L.M., R.A. Woutersen, V.J. Feron, R.N. Hooftman and W.R.F. Notten. 1986. Effect of variable versus fixed exposure levels on the toxicity of acetaldehyde in rats. J. Appl. Toxicol. 6(5): 331-336. ; Appleman, L.M., R.A. Woutersen, and V.J. Feron. 1982. Inhalation toxicity of acetaldehyde in rats. I. Acute and subacute studies. Toxicology. 23: 293-297.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a545f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=290; TOXICOLOGICAL_EFFECT=degeneration of olfactory epithelium; STUDY_GROUP=IRIS_dup_IRIS Summary_15644188_15644189_15644190_15644191_15644192_15644193:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_29f6729b6bb791c35e9027092fdecfc1 |
| ToxValDB IRIS | NOAEL | =273 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | LONG_REF=Appleman, L.M., R.A. Woutersen, V.J. Feron, R.N. Hooftman and W.R.F. Notten. 1986. Effect of variable versus fixed exposure levels on the toxicity of acetaldehyde in rats. J. Appl. Toxicol. 6(5): 331-336. ; Appleman, L.M., R.A. Woutersen, and V.J. Feron. 1982. Inhalation toxicity of acetaldehyde in rats. I. Acute and subacute studies. Toxicology. 23: 293-297.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a545f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=290; TOXICOLOGICAL_EFFECT=degeneration of olfactory epithelium; STUDY_GROUP=IRIS_dup_IRIS Summary_15644188_15644189_15644190_15644191_15644192_15644193:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_05d40dd1d7f69633a6d072cef8676c32 |
| ToxValDB IRIS | NOAEL (ADJ) | =48.75 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | LONG_REF=Appleman, L.M., R.A. Woutersen, V.J. Feron, R.N. Hooftman and W.R.F. Notten. 1986. Effect of variable versus fixed exposure levels on the toxicity of acetaldehyde in rats. J. Appl. Toxicol. 6(5): 331-336. ; Appleman, L.M., R.A. Woutersen, and V.J. Feron. 1982. Inhalation toxicity of acetaldehyde in rats. I. Acute and subacute studies. Toxicology. 23: 293-297.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a545f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=290; TOXICOLOGICAL_EFFECT=degeneration of olfactory epithelium; STUDY_GROUP=IRIS_dup_IRIS Summary_15644188_15644189_15644190_15644191_15644192_15644193:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6c2823bf6944db829ef400f27e6742c0 |
| ToxValDB IRIS | NOAEL (HEC) | =8.7 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | LONG_REF=Appleman, L.M., R.A. Woutersen, V.J. Feron, R.N. Hooftman and W.R.F. Notten. 1986. Effect of variable versus fixed exposure levels on the toxicity of acetaldehyde in rats. J. Appl. Toxicol. 6(5): 331-336. ; Appleman, L.M., R.A. Woutersen, and V.J. Feron. 1982. Inhalation toxicity of acetaldehyde in rats. I. Acute and subacute studies. Toxicology. 23: 293-297.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a545f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=290; TOXICOLOGICAL_EFFECT=degeneration of olfactory epithelium; STUDY_GROUP=IRIS_dup_IRIS Summary_15644188_15644189_15644190_15644191_15644192_15644193:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a1b245daf7de39d5df16fb287db090b3 |
| ToxValDB IRIS | RfC | =0.009 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Appleman, L.M., R.A. Woutersen, V.J. Feron, R.N. Hooftman and W.R.F. Notten. 1986. Effect of variable versus fixed exposure levels on the toxicity of acetaldehyde in rats. J. Appl. Toxicol. 6(5): 331-336. ; Appleman, L.M., R.A. Woutersen, and V.J. Feron. 1982. Inhalation toxicity of acetaldehyde in rats. I. Acute and subacute studies. Toxicology. 23: 293-297.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a545f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=290; TOXICOLOGICAL_EFFECT=Degeneration of olfactory epithelium in male/female rats; STUDY_GROUP=IRIS:15644194:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ffebe259d55b456ae7253fc0d1d13ca3 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | GO1N1ZPR3B | UNII | - | - | - | chemical | - |