NOAEL Studies
Cosmetic Ingredient
Acetone NOAEL Studies
INCI: ACETONE
CAS: 67-64-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ATSDR_toxval_ATSDR_MRLs.xlsx 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ATSDR_toxval_ATSDR_MRLs.xlsx | LOAEL | =562.987 | mg/m3 | Human (M/F) | inhalation | acute; 4 hours | clinical | ATSDR MRLs; row_hash=387fc82567b5bcd1; source_hash=ToxValhc_69d321c9eefd9b803b194bb3b485625a; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=237; raw_unit=ppm; effect=neurological; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Dick RB, Setzer JV, Taylor BJ, et al. 1989. Neurobehavioural effects of short duration exposures to acetone and methyl ethyl ketone. Occup Environ Med 46(2):111-121.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bff |
COSMOS_DB 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 42 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1144 | mg/kg bw/day | mouse | oral | 28 day | Immunotoxicology | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1700 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1788 | mg/kg bw/day | rat | oral | 7 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 2500 | mg/kg bw/day | mouse | oral | 7 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 3896 | mg/kg bw/day | mouse | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 4312 | mg/kg bw/day | rat | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 5000 | mg/kg bw/day | rat | oral | 10 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 6400 | mg/kg bw/day | syrian hamster | oral | 7 day | Immunotoxicology | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 11298 | mg/kg bw/day | mouse | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 30 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 3400 | mg/kg bw/day | rat | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=70525995-a6a0-409a-a879-9b36a3e9f409 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 1700 | mg/kg bw/day | rat | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=49738217-3289-4bd8-aba9-b279f6e2d025 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=e0508d65-2792-4c7e-ad7b-84534f30cf00_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=e0508d65-2792-4c7e-ad7b-84534f30cf00/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; key_result=false; entry_uuid=d9e21c1d-099d-4fcc-83fe-478b4a9d563e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 3400 | mg/kg bw/day | rat | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=70525995-a6a0-409a-a879-9b36a3e9f409 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 1700 | mg/kg bw/day | rat | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=49738217-3289-4bd8-aba9-b279f6e2d025 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=e0508d65-2792-4c7e-ad7b-84534f30cf00_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=e0508d65-2792-4c7e-ad7b-84534f30cf00/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; key_result=false; entry_uuid=d9e21c1d-099d-4fcc-83fe-478b4a9d563e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 3400 | mg/kg bw/day | rat | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=70525995-a6a0-409a-a879-9b36a3e9f409 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 1700 | mg/kg bw/day | rat | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=49738217-3289-4bd8-aba9-b279f6e2d025 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=e0508d65-2792-4c7e-ad7b-84534f30cf00_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=e0508d65-2792-4c7e-ad7b-84534f30cf00/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; key_result=false; entry_uuid=d9e21c1d-099d-4fcc-83fe-478b4a9d563e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 650 | mg/kg bw/day | rat | oral: drinking water | - | neurotoxicity: short-term oral | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=af150532-580c-43bd-b428-498a95b59900_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=af150532-580c-43bd-b428-498a95b59900/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=2000; basis=other:; key_result=false; entry_uuid=878c4a62-e252-46d1-850b-194ac6613a85 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1144 | mg/kg bw/day | mouse | oral: drinking water | - | immunotoxicity: short-term oral | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=4e91c3c9-b6fa-4d09-9210-5320b2b7c4ee_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=4e91c3c9-b6fa-4d09-9210-5320b2b7c4ee/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=Immunotoxicity; literature=Name=Unnamed; ReferenceYear=2006; basis=other:; key_result=false; entry_uuid=94e31619-4c93-471f-b6b7-df2613811a6e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 900 | mg/kg bw/day | rat | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=8dd90bdc-27a3-4d09-ab6b-82a80fde39ca |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=e0508d65-2792-4c7e-ad7b-84534f30cf00_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=e0508d65-2792-4c7e-ad7b-84534f30cf00/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; key_result=false; entry_uuid=311194ba-2b96-4a71-9b32-4118fe9b1a16 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 650 | mg/kg bw/day | rat | oral: drinking water | - | neurotoxicity: short-term oral | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=af150532-580c-43bd-b428-498a95b59900_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=af150532-580c-43bd-b428-498a95b59900/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=2000; basis=other:; key_result=false; entry_uuid=878c4a62-e252-46d1-850b-194ac6613a85 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1144 | mg/kg bw/day | mouse | oral: drinking water | - | immunotoxicity: short-term oral | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=4e91c3c9-b6fa-4d09-9210-5320b2b7c4ee_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=4e91c3c9-b6fa-4d09-9210-5320b2b7c4ee/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=Immunotoxicity; literature=Name=Unnamed; ReferenceYear=2006; basis=other:; key_result=false; entry_uuid=94e31619-4c93-471f-b6b7-df2613811a6e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 900 | mg/kg bw/day | rat | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=8dd90bdc-27a3-4d09-ab6b-82a80fde39ca |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=e0508d65-2792-4c7e-ad7b-84534f30cf00_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=e0508d65-2792-4c7e-ad7b-84534f30cf00/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; key_result=false; entry_uuid=311194ba-2b96-4a71-9b32-4118fe9b1a16 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 650 | mg/kg bw/day | rat | oral: drinking water | - | neurotoxicity: short-term oral | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=af150532-580c-43bd-b428-498a95b59900_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=af150532-580c-43bd-b428-498a95b59900/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=2000; basis=other:; key_result=false; entry_uuid=878c4a62-e252-46d1-850b-194ac6613a85 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1144 | mg/kg bw/day | mouse | oral: drinking water | - | immunotoxicity: short-term oral | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=4e91c3c9-b6fa-4d09-9210-5320b2b7c4ee_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=4e91c3c9-b6fa-4d09-9210-5320b2b7c4ee/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=Immunotoxicity; literature=Name=Unnamed; ReferenceYear=2006; basis=other:; key_result=false; entry_uuid=94e31619-4c93-471f-b6b7-df2613811a6e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 900 | mg/kg bw/day | rat | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=8dd90bdc-27a3-4d09-ab6b-82a80fde39ca |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=e0508d65-2792-4c7e-ad7b-84534f30cf00_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=e0508d65-2792-4c7e-ad7b-84534f30cf00/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; key_result=false; entry_uuid=311194ba-2b96-4a71-9b32-4118fe9b1a16 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 3100 | mg/kg bw/day | rat | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=56f18bfa-03c6-4dc3-b502-37ccc6ab0e86 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 4858 | mg/kg bw/day | mouse | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=59fdd8d8-1f35-4ee3-a929-9d42e559cd07_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=59fdd8d8-1f35-4ee3-a929-9d42e559cd07/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=e7e8635f-5d20-43c6-8694-f1d7e49a6937 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 11298 | mg/kg bw/day | mouse | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=59fdd8d8-1f35-4ee3-a929-9d42e559cd07_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=59fdd8d8-1f35-4ee3-a929-9d42e559cd07/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=324b0da6-c3b9-44f7-bf8d-9f56056dd17d |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 3100 | mg/kg bw/day | rat | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=56f18bfa-03c6-4dc3-b502-37ccc6ab0e86 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 4858 | mg/kg bw/day | mouse | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=59fdd8d8-1f35-4ee3-a929-9d42e559cd07_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=59fdd8d8-1f35-4ee3-a929-9d42e559cd07/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=e7e8635f-5d20-43c6-8694-f1d7e49a6937 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 11298 | mg/kg bw/day | mouse | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=59fdd8d8-1f35-4ee3-a929-9d42e559cd07_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=59fdd8d8-1f35-4ee3-a929-9d42e559cd07/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=324b0da6-c3b9-44f7-bf8d-9f56056dd17d |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 3100 | mg/kg bw/day | rat | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=ee5f6daf-6e70-4fc3-a8d9-e23fa58d3522/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=56f18bfa-03c6-4dc3-b502-37ccc6ab0e86 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 4858 | mg/kg bw/day | mouse | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=59fdd8d8-1f35-4ee3-a929-9d42e559cd07_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=59fdd8d8-1f35-4ee3-a929-9d42e559cd07/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=e7e8635f-5d20-43c6-8694-f1d7e49a6937 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 11298 | mg/kg bw/day | mouse | oral: drinking water | - | reproductive toxicity, other | dossier=e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6z; document=59fdd8d8-1f35-4ee3-a929-9d42e559cd07_e2c59a20-8996-4eda-be81-9ff4ae2e0e1e.i6d; document_key=59fdd8d8-1f35-4ee3-a929-9d42e559cd07/e2c59a20-8996-4eda-be81-9ff4ae2e0e1e; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1991; basis=other:; key_result=false; entry_uuid=324b0da6-c3b9-44f7-bf8d-9f56056dd17d |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =900 | mg/kg bw/day | Rat | oral: drinking water | 90 days | subchronic | EFSA CONTAM - 2012 - OutputID 602 - Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part II of III - doi:10.2903/j.efsa.2012.2703 |
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | =0.9 | mg/kg bw/day | Consumers | - | - | ADI | EFSA CONTAM - 2012 - OutputID 602 - Consumers - Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part II of III - doi:10.2903/j.efsa.2012.2703 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | =0.9 | mg/kg bw/day | Consumers | - | - | ADI | EFSA CONTAM - 2012 - OutputID 602 - Consumers - Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part II of III - doi:10.2903/j.efsa.2012.2703 |
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfd_systems.csv | NOAEL | =900 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=c32e80ec3dc1eef4; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 900 mg/kg-day; system=Urinary; basis=Nephropathy; point_of_departure=NOAEL : 900 mg/kg-day; composite_uf=1000; confidence=Medium; dtxsid=DTXSID8021482; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=128; rfd_last_updated=07/31/2003; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0128_summary.pdf |
| EPA_IRIS_iris_rfd_systems.csv | RfD | =0.9 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=f7c1886ad7eb5a45; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=9e-1; system=Urinary; basis=Nephropathy; point_of_departure=NOAEL : 900 mg/kg-day; composite_uf=1000; confidence=Medium; dtxsid=DTXSID8021482; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=128; rfd_last_updated=07/31/2003; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0128_summary.pdf |
INCHEM_WHO_ehc_ehc_ehc207 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_ehc_ehc_ehc207 | NOAEL | =500 | mg/kg bw/day | Rat | oral | 90-day | Subchronic toxicity | document_id=ehc_ehc_ehc207; title=Acetone (EHC 207, 1998); path=mirror/documents/ehc/ehc/ehc207.htm; row_hash=706f71ead7f9ab80; raw_unit=mg/kg per day; context=In a 90-day gavage study of rats, increased blood parameters (increased haemoglobin, haematocrit) were observed at dose levels >500 mg/kg per day, and a NOAEL of 500 mg/kg per day was identified. |
| INCHEM_WHO_ehc_ehc_ehc207 | NOAEL | =2200 | ppm | Rat; Mouse | - | - | Developmental toxicity | document_id=ehc_ehc_ehc207; title=Acetone (EHC 207, 1998); path=mirror/documents/ehc/ehc/ehc207.htm; row_hash=4604ed99df325fbb; raw_unit=ppm; context=An atmospheric concentration of 5200 mg/m 3 (2200 ppm) was identified as a NOAEL for developmental toxicity in both mice and rats. |
| INCHEM_WHO_ehc_ehc_ehc207 | NOAEL | =500 | mg/kg bw | Rat | oral | - | Toxicology study | document_id=ehc_ehc_ehc207; title=Acetone (EHC 207, 1998); path=mirror/documents/ehc/ehc/ehc207.htm; row_hash=9466d103e280a203; raw_unit=mg/kg; context=es rats par gavage, on a observé une augmentation de certains paramètres hématologiques (hémoglobine, hématocrite) aux doses supérieures à 500 mg/kg par jour et on a déterminé une NOAEL (dose sans effet nocif observable) de 500 mg/kg par jour. |
| INCHEM_WHO_ehc_ehc_ehc207 | NOEL | =3110 | mg/L | - | - | - | Toxicology study | document_id=ehc_ehc_ehc207; title=Acetone (EHC 207, 1998); path=mirror/documents/ehc/ehc/ehc207.htm; row_hash=48a09517592513cf; raw_unit=mg/litre; context=For Daphnia magna , EC 50 values for number of progeny, number of broods and mean brood size were 6369, 6406 and 6714 mg/litre, and the corresponding NOEL values were 3110, 5184 and 3110 mg/litre. |
| INCHEM_WHO_ehc_ehc_ehc207 | NOEL | =5184 | mg/L | - | - | - | Toxicology study | document_id=ehc_ehc_ehc207; title=Acetone (EHC 207, 1998); path=mirror/documents/ehc/ehc/ehc207.htm; row_hash=ff62614403c5e972; raw_unit=mg/litre; context=The EC 50 values for Ceriodaphnia dubia were 6469, 5908 and 6928 mg/litre, and the corresponding NOEL values were 5184 mg/litre for all three parameters. |
| INCHEM_WHO_ehc_ehc_ehc207 | NOEL | =900 | mg/kg bw/day | Rat | oral | 13-week | Subchronic toxicity | document_id=ehc_ehc_ehc207; title=Acetone (EHC 207, 1998); path=mirror/documents/ehc/ehc/ehc207.htm; row_hash=ef26ef9ba47fa2f9; raw_unit=mg/kg body weight per day; context=From the available shorter-term studies, a no-observed-effect level in a 13-week drinking-water study in rats of 900 mg/kg body weight per day (male rats), based on parameters including changes in organ weights, was selected. |
INCHEM_WHO_jecfa_jecmono_v042je15 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jecfa_jecmono_v042je15 | NOEL | =20 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je15; title=941. Saturated aliphatic acyclic secondary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je15.htm; row_hash=c04011187df189c5; raw_unit=mg/kg bw per day; context=The NOEL was 20 mg/kg bw per day (Gaunt et al., 1972). |
| INCHEM_WHO_jecfa_jecmono_v042je15 | NOEL | =20 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je15; title=941. Saturated aliphatic acyclic secondary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je15.htm; row_hash=c04011187df189c5; raw_unit=mg/kg bw per day; context=The NOEL was 20 mg/kg bw per day (Gaunt et al., 1972). |
| INCHEM_WHO_jecfa_jecmono_v042je15 | NOEL | =100 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je15; title=941. Saturated aliphatic acyclic secondary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je15.htm; row_hash=fc295b640a92ebd8; raw_unit=mg/kg bw per day; context=The NOEL was 100 mg/kg bw per day (Sonawane et al., 1986). |
| INCHEM_WHO_jecfa_jecmono_v042je15 | NOEL | =100 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je15; title=941. Saturated aliphatic acyclic secondary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je15.htm; row_hash=fc295b640a92ebd8; raw_unit=mg/kg bw per day; context=The NOEL was 100 mg/kg bw per day (Sonawane et al., 1986). |
| INCHEM_WHO_jecfa_jecmono_v042je15 | NOEL | =870 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je15; title=941. Saturated aliphatic acyclic secondary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je15.htm; row_hash=9e8aeba054779bb2; raw_unit=mg/kg bw per day; context=The NOEL was 870 mg/kg bw per day (Pilegaard & Ladefoged, 1993). |
| INCHEM_WHO_jecfa_jecmono_v042je15 | NOEL | =870 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je15; title=941. Saturated aliphatic acyclic secondary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je15.htm; row_hash=9e8aeba054779bb2; raw_unit=mg/kg bw per day; context=The NOEL was 870 mg/kg bw per day (Pilegaard & Ladefoged, 1993). |
| INCHEM_WHO_jecfa_jecmono_v042je15 | NOEL | =1000 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v042je15; title=941. Saturated aliphatic acyclic secondary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je15.htm; row_hash=852c52557a0c1265; raw_unit=mg/kg bw per day; context=285) to male rats, the NOEL was 1000 mg/kg bw per day (O'Donoghue et al., 1984). |
| INCHEM_WHO_jecfa_jecmono_v042je15 | NOEL | =1000 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v042je15; title=941. Saturated aliphatic acyclic secondary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je15.htm; row_hash=852c52557a0c1265; raw_unit=mg/kg bw per day; context=285) to male rats, the NOEL was 1000 mg/kg bw per day (O'Donoghue et al., 1984). |
| INCHEM_WHO_jecfa_jecmono_v042je15 | NOEL | =2500 | mg/kg bw/day | - | oral | - | Toxicology study | document_id=jecfa_jecmono_v042je15; title=941. Saturated aliphatic acyclic secondary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je15.htm; row_hash=e2f14c45fd684a1d; raw_unit=mg/kg bw per day; context=The NOEL was 2500 mg/kg bw per day (Dietz, 1991). |
| INCHEM_WHO_jecfa_jecmono_v042je15 | NOEL | =2500 | mg/kg bw/day | - | oral | - | Toxicology study | document_id=jecfa_jecmono_v042je15; title=941. Saturated aliphatic acyclic secondary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je15.htm; row_hash=e2f14c45fd684a1d; raw_unit=mg/kg bw per day; context=The NOEL was 2500 mg/kg bw per day (Dietz, 1991). |
NTP_ICE_acute_inhalation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 132.2308 | mg/L | - | Inhalation | Duration=3 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4384; Record_ID=acute_inhalation_2258; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=132.2308; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_acute_inhalation | LC50 | 50.1 | mg/L | - | Inhalation | Duration=8 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4385; Record_ID=acute_inhalation_2769; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=50.1; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_acute_inhalation | LC50 | 76 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4386; Record_ID=acute_inhalation_2252; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=76; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_acute_inhalation | LC50 | 75.9579 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4387; Record_ID=acute_inhalation_2254; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=75.9579; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_acute_inhalation | LC50 | 50.0697 | mg/L | - | Inhalation | Duration=8 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4388; Record_ID=acute_inhalation_2256; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=50.0697; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =9800 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9198; row=13304; data_type=In Vivo; mixture=Chemical; chemical_name=Acetone; preferred_name=Acetone; dtxsid=DTXSID8021482; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021482; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =5800 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9194; row=13305; data_type=In Vivo; mixture=Chemical; chemical_name=Acetone; preferred_name=Acetone; dtxsid=DTXSID8021482; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021482; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =8450 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9196; row=13306; data_type=In Vivo; mixture=Chemical; chemical_name=Acetone; preferred_name=Acetone; dtxsid=DTXSID8021482; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021482; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | NOEL | 1000 | mg/kg bw/day | Rat | Oral | Treatment_Duration=10 days; Age_at_First_Dose=PND 54; Age_Ovariectomized_or_Castrated=PND 42; Time_Elapsed_Between_Surgery_and_Treatment=12 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 36 hours; Number_of_Doses_Tested=6 | In Vivo; Hershberger-Agonist | sheet=Data_invivo; excel_row=1069; Record_ID=endocrine_invivo_460; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Hershberger-Agonist; Endpoint=NOEL; Response=1000; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Sprague-Dawley; Strain=Sprague-Dawley; Sex=Male (castrated); Route=Oral; Reference_Hormone=Testosterone propionate; Reference_Hormone_Dose=0.2; Reference_Hormone_Dose_Units=mg/kg/day; Reference_Hormone_Route=Subcutaneous; Additional_Information=Browne et al. 2018 unique record identifier 415; Reference=US EPA 2015; Not available; https://www.regulations.gov/document/EPA-HQ-OPP-2009-0634-0252|Browne et al. 2018; 30205136; 10.1016/j.reprotox.2018.08.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
NTP_ICE_eye_irritation 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 65.8 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2301; Record_ID=eye_irritation_159; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=65.8; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 65.8 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2301; Record_ID=eye_irritation_159; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=65.8; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 65.8 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2301; Record_ID=eye_irritation_159; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=65.8; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 65.8 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2301; Record_ID=eye_irritation_159; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=65.8; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2296; Record_ID=eye_irritation_159; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2296; Record_ID=eye_irritation_159; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2296; Record_ID=eye_irritation_159; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2296; Record_ID=eye_irritation_159; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Intensity | 0.21 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2300; Record_ID=eye_irritation_1297; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Vitrigel; Endpoint=Intensity; Response=0.21; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Intensity | 0.21 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2300; Record_ID=eye_irritation_1297; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Vitrigel; Endpoint=Intensity; Response=0.21; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Intensity | 0.21 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2300; Record_ID=eye_irritation_1297; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Vitrigel; Endpoint=Intensity; Response=0.21; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Intensity | 0.21 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2300; Record_ID=eye_irritation_1297; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Vitrigel; Endpoint=Intensity; Response=0.21; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2295; Record_ID=eye_irritation_1297; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2295; Record_ID=eye_irritation_1297; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2295; Record_ID=eye_irritation_1297; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2295; Record_ID=eye_irritation_1297; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Plateau level | 10 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2299; Record_ID=eye_irritation_1297; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Vitrigel; Endpoint=Plateau level; Response=10; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Plateau level | 10 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2299; Record_ID=eye_irritation_1297; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Vitrigel; Endpoint=Plateau level; Response=10; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Plateau level | 10 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2299; Record_ID=eye_irritation_1297; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Vitrigel; Endpoint=Plateau level; Response=10; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_eye_irritation | Plateau level | 10 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2299; Record_ID=eye_irritation_1297; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Vitrigel; Endpoint=Plateau level; Response=10; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
NTP_ICE_skin_sensitization 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=9363; Record_ID=skin_sensitization_invivo_2076; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
| NTP_ICE_skin_sensitization | Relative reliability score | 4 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=9367; Record_ID=skin_sensitization_invivo_2076; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021482; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021482; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021482 |
ToxValDB_ATSDR_MRLs 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ATSDR_MRLs | BMDL (1SD) | =57 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dietz DD, Leininger JR, Rauckman EJ, et al. 1991. Toxicity studies of acetone administered in the drinking water of rodents. Toxicol Sci 17(2):347-360. https://doi.org/10.1093/toxsci/17.2.34. ; NTP. 1991. National Toxicology Program - technical report no. 3. Toxicity studies of acetone in F344/N rats and B6C3F, mice (drinking water studies). U.S. Department of Health and Human Services, Public Health Service, National Institute of Health. NIH publication no. 91-3122.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bff; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp21.pdf; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ATSDR MRLs:15447323:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_266cd0902a0ee7f64b0bb9d10c486e88 |
| ToxValDB_ATSDR_MRLs | LOAEL | =562.987 | mg/m3 | Human | inhalation | acute; 4 hours | clinical | LONG_REF=Dick RB, Setzer JV, Taylor BJ, et al. 1989. Neurobehavioural effects of short duration exposures to acetone and methyl ethyl ketone. Occup Environ Med 46(2):111-121.; TITLE=Neurobehavioural effects of short duration exposures to acetone and methyl ethyl ketone; AUTHOR=Dick RB; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bff; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp21.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447322:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_69d321c9eefd9b803b194bb3b485625a |
| ToxValDB_ATSDR_MRLs | MRL | =19.0038 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2022; ORIGINAL_YEAR=2022; TOXICOLOGICAL_EFFECT=neurological; STUDY_GROUP=ATSDR MRLs:15446844:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d09e004b40b8aa3d487f134275116196 |
| ToxValDB_ATSDR_MRLs | MRL | =0.6 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2022; ORIGINAL_YEAR=2022; TOXICOLOGICAL_EFFECT=hematological in male rats; STUDY_GROUP=ATSDR MRLs:15446845:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9c2a3587d1c5d23d83d61c1e4c1e42a5 |
| ToxValDB_ATSDR_MRLs | MRL | =19.0038 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2022; ORIGINAL_YEAR=2022; TOXICOLOGICAL_EFFECT=neurological; STUDY_GROUP=ATSDR MRLs:15446844:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d09e004b40b8aa3d487f134275116196 |
| ToxValDB_ATSDR_MRLs | MRL | =0.6 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2022; ORIGINAL_YEAR=2022; TOXICOLOGICAL_EFFECT=hematological in male rats; STUDY_GROUP=ATSDR MRLs:15446845:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9c2a3587d1c5d23d83d61c1e4c1e42a5 |
ToxValDB_Alaska_DEC 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Alaska_DEC | RfC | =3.15 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446028:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=727f3ffdea2e8b8c6d9a6655d882fe88 |
| ToxValDB_Alaska_DEC | RfC | =3.15 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446028:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=727f3ffdea2e8b8c6d9a6655d882fe88 |
| ToxValDB_Alaska_DEC | RfD | =0.747 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446026:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=d1585356a7d1e8815510910a3164b9a1 |
| ToxValDB_Alaska_DEC | RfD | =0.9 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446027:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=077a8231365da6e51a1d27ea678fa3a3 |
| ToxValDB_Alaska_DEC | RfD | =0.747 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446026:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=d1585356a7d1e8815510910a3164b9a1 |
| ToxValDB_Alaska_DEC | RfD | =0.9 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446027:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=077a8231365da6e51a1d27ea678fa3a3 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =61762.3 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=DOE Protective Action Criteria:15511782:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_125f37054bbd197b86ff99275a4d70cf |
ToxValDB_DOE_Wildlife_Benchmarks 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Wildlife_Benchmarks | LOAEL | =50 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511521_15511522:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0d70edc809de3ab763a82633c9a5d483 |
| ToxValDB_DOE_Wildlife_Benchmarks | NOAEL | =10 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511521_15511522:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25576bc86298d99f1c525c648c54b2f0 |
ToxValDB_ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =200 | uL | Mouse | dermal | chronic; 184 days | chronic | LONG_REF=Toxicology163(1): 1-9 Shukla,Y., A. Arora, and A. Singh Tumourigenic Studies on Deltamethrin in Swiss Albino Mice 2001; TITLE=Tumourigenic Studies on Deltamethrin in Swiss Albino Mice; AUTHOR=Shukla,Y., A. Arora, and A. Singh; DOI=10.1016/s0300-483x(00)00416-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=109908; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15597661:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f2127a88c494a8cb0bb79f57215ed9a2 |
| ToxValDB_ECOTOX | NOEL | =20 | mg/org | Mouse | dermal | chronic; 800 days | chronic | LONG_REF=J. Toxicol. Environ. Health14:115-120 DePass,L.R., E.H. Fowler, D.R. Meckley, and C.S. Weil Dermal Oncogenicity Bioassays of Acrylic Acid, Ethyl Acrylate, and Butyl Acrylate 1984; TITLE=Dermal Oncogenicity Bioassays of Acrylic Acid, Ethyl Acrylate, and Butyl Acrylate; AUTHOR=DePass,L.R., E.H. Fowler, D.R. Meckley, and C.S. Weil; DOI=10.1080/15287398409530566; QUALITY=Control type: Positive control; EXTERNAL_SOURCE_ID=91232; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Injury: Tumor induction|Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|mortality/survival; STUDY_GROUP=ECOTOX:15611309:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=82cad0ec92a19c9c24e985c09e6146d4 |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =900 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA CONTAM (2012). Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part II of III. doi:10.2903/j.efsa.2012.2703.; TITLE=Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part II of III; AUTHOR=EFSA CONTAM; DOI=doi:10.2903/j.efsa.2012.2703; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=EFSA:15624197:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b2e01107b3af9a35fb61fdd83b2571d7 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =1210 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629475:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7de67f04086a7a03b4d1ead18bd9be37 |
ToxValDB_HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOEL | =380 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e17e4b0a676289df72d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Body Weight Changes: decrease|Water Consumption: decrease|Hematology: WBC increase, Lymph increase, Hgb decrease, RBC decrease, MCH increase, MCV increase, Plt decrease, Ret decrease|Absolute Organ Weight: Right kidney increase|Relative Organ Weight: Right kidney increase, Liver increase, Lung increase|Histopathology: Spleen-Pigmentation,Kidney-Nephropathy(mild)|Reproductive Endpoint: Reproductive end point', 'Caudal weight decrease, Right epididymis weight decrease, Abnormal sperm increase, Sperm motility decrease, Sperm density decrease; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|multiple|nonneoplastic histopathology|organ weight; STUDY_GROUP=HESS:15638359:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4c8a31d04581a0b0b1ef40867cb92b81 |
ToxValDB_IRIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_IRIS | LOAEL | =1700 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dietz, DD; Leininger, JR; Rauckman, EJ; et al. (1991) Toxicity studies of acetone administered in the drinking water of rodents. Fund. Appl. Toxicol. 17:347-360. ; NTP (National Toxicology Program). (1991) Toxicity studies of acetone (CAS No. 67-64-1) in F344/N rats and B6C3F1 mice (drinking water studies). NTP, Research Triangle Park, NC. NTP TOX 3, NIH Publication No. 91-3122.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a504e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=128; TOXICOLOGICAL_EFFECT=nephropathy; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15644887_15644889:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e0faeb8dc24e6cf8166f9205029f6d64 |
ToxValDB_NIOSH_IDLH 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_NIOSH_IDLH | NEL | =4988.49 | mg/m3 | Human | inhalation | - | occupational | LONG_REF=Haggard HW, Greenberg LA, Turner Jmcc [1944]. The physiological principles governing the action of acetone together with determination of toxicity. J Ind Hyg Toxicol 26(5):133-151.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b377e4b02565fc7d6e3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/67641.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=No indications of toxicity; STUDY_GROUP=NIOSH IDLH:15952978:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a8e704753f7f8dd8d93f4b1d9b1da22c |
| ToxValDB_NIOSH_IDLH | NEL | =2375.47 | mg/m3 | Human | inhalation | - | occupational | LONG_REF=Raleigh RL, McGee WA [1972]. Effects of short, high-concentration exposures to acetone as determined by observation in the work area. J Occup Med 14(8):607-610; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b377e4b02565fc7d6e3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/67641.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Eye irritation, headache, lightheadedness, nasal irritation, and throat irritation; STUDY_GROUP=NIOSH IDLH:15952979:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_821286851ddcf547bf887753f75c1838 |
ToxValDB_Pennsylvania_DEP_ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Pennsylvania_DEP_ToxValues | RfC | =31 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15649770:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_49a3785f1c366774a640ece3fb3b3287 |
ToxValDB_TX_TCEQ 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_TX_TCEQ | LOAEL | =539.232 | mg/m3 | Human | inhalation | acute; 2 hours | clinical | LONG_REF=Dick RB, Setzer JV, Taylor BJ, & Shukla R. 1989. Neurobehavioural effects of short duration exposures to acetone and methyl ethyl ketone. [Clinical Trial Controlled Clinical Trial]. Br J Ind Med, 46(2), 111-121; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b47; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/acetone.pdf; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Mild effects on neurobehavioral performance; STUDY_GROUP=TX TCEQ:15954295:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1d975660066d653b59655e54ae6f14e1 |
| ToxValDB_TX_TCEQ | LOAEL | =890.802 | mg/m3 | Human | inhalation | chronic; 14.9 years | occupational | LONG_REF=Satoh T, Omae K, Nakashima H, Takebayashi T, Matsumura H, Kawai T, et al. 1996. Relationship between acetone exposure concentration and health effects in acetate fiber plant workers. [Comparative Study Research Support, Non-U.S. Gov't]. Int Arch Occup Environ Health, 68(3), 147-153; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b47; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/acetone.pdf; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Neurotoxicity (heavy feelings in the head, faint feelings, nausea); STUDY_GROUP=TX TCEQ:15954296:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d5ab4a5d25a986e36dc624bdc1c6a675 |
ToxValDB_Uterotrophic_Hershberger_DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Uterotrophic_Hershberger_DB | NOEL | =1000 | mg/kg bw/day | Rat | oral | short-term; 10 days | Hershberger | LONG_REF=Acetone: Data Evaluation Records (DERs) for EDSP Tier 1 Assays Docket Number: EPA-HQ-OPP-2009-0634. Available at: http://www.regulations.gov/contentStreamer?documentId=EPA-HQ-OPP-2009-0634-0252&disposition=attachment&contentType=pdf; TITLE=Acetone: Data Evaluation Records (DERs) for EDSP Tier 1 Assays Docket Number: EPA-HQ-OPP-2009-0634; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40a; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=inactive|Negative|Negative|neither|see comment; STUDY_GROUP=Uterotrophic Hershberger DB:15714286:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8af18bc1b7612c373b85381aeb3595a8 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 1364PS73AF | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C3H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1364PS73AF"} |