Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Acetone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 4312 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 3896 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1700 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 11298 mg/kg bw/day | oral | mouse | Subchronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
| NOAEL | 1788 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 6400 mg/kg bw/day | oral | syrian hamster | Immunotoxicology | COSMOS_DB |
| NOAEL | 1144 mg/kg bw/day | oral | mouse | Immunotoxicology | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Potent defatting agent causing dryness, cracking, and irritant contact dermatitis with repeated dermal exposure. Inhalation risk as CNS depressant at high concentrations. VOC with workplace exposure limits (OSHA PEL 1000 ppm TWA). Flammable; adequate ventilation required in nail salon applications.
Regulatory Flags
Frequently Asked Questions
Is Acetone safe in cosmetics?
Potent defatting agent causing dryness, cracking, and irritant contact dermatitis with repeated dermal exposure. Inhalation risk as CNS depressant at high concentrations. VOC with workplace exposure limits (OSHA PEL 1000 ppm TWA). Flammable; adequate ventilation required in nail salon applications. The EU classifies Acetone as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Acetone allowed in the EU?
Acetone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetone do in cosmetics?
Acetone functions as: Solvent, denaturant. It is classified as a cosmetic ingredient in our database. CAS number: 67-64-1.
What is the Margin of Safety for Acetone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Acetone?
The NOAEL (No Observed Adverse Effect Level) for Acetone is 4312 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Acetone classified as hazardous under GHS?
Acetone carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Causes eye irritation May cause respiratory irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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